271 research outputs found
Data Set of PLOS Computational Paper PCOMPBIOL-D-18-02181R1
No full textFigures Data of PLOS Computational paper:Modeling of the axon plasma membrane structure and its effects on protein diffusionAuthors: Yihao Zhang, Anastasios V. Tzingounis, and George LykotrafitisCorresponding Author: George Lykotrafitis, Ph.D.University of ConnecticutStorss, CT UNITED STATES</div
The state of modern Greek language as spoken in Victoria
No full textDeposited with permission of the author. © 1986 Dr. Anastasios TamisThis thesis reports a sociolinguistic study, carried out between 1981 and 1984, of the state of the Modern Greek (MG) language in Australia, as spoken by native-speaking first-generation Greek immigrants in Victoria. Particular emphasis is given to the analysis of those characteristics of the linguistic behaviour of these Greek Australians which can be attributed to the contact with English and to other environmental, social and linguistic influence. (For complete abstract open document
New historical evidence for Anastasios Emm. Papas
No full textNo AbstractThe author’s attention has been drawn to the existence of this historicalevidence in the National Archives of Vienna, by his friend the writer EteoclesGregoriadis together with the numbers of the relevant files. Most of the documents were written in the old German script. Thus the author asked for the help of his friend and former colleague at the University of Thessaloniki and director of the Goethe Institute, Graf Kurt v. Posadowsky, for reading andstudying those documents. Without his help this study would have been impossible. This new evidence concerns the sojourn of Anastasios Papas·—son of Emmanuel Papas, leading figure of the Greek Revolution—in Austria andGermany between the 3rd January and 11th March 1822. There is informationabout his short imprisonment in Trieste, after his arival from Vienna. He then visits various towns in Germany and after negotiations with the Philhellene professor Fr. Thiersch in Munich, he purchases large quantities of ammunition to be despatched to Greece. He finally arrives in Greece early in 1824, and takes part—together with his three brothers who were already fighting—in the struggle for the liberation of the common great fartheland
VERTICAL GASTROPLASTY AS A TREATMENT FOR CLINICALLY SEVERE OBESITY. A CLINICAL AND BIOCHEMICAL EVALUATION
No full textIN THIS STUDY THE OUTCOME IN 35 PATIENTS WITH CLINICALLY SEVERE OBESITY (MORBIDOBESITY) WHO UNDERWENT VERTICAL BANDED OR VERTICAL RING GASTROPLASTY IS DESCRIBED. THE PATIENTS WERE SELECTED ACCORDING THE ESTABLISHED CRITERIA FOR OBESITY SURGERY. AFTER AN EXTENSIVE PREOPERATIVE EVALUATIONS 15 PATIENTS UNDERWENT V.B.G. AND 20 PATIENTS UNDERWENT V.R.G. DURING THE 56-MONTH FOLLOW-UP A QUITE SATISFACTORY WEIGHT LOSS WAS ACHIEVED WITH NO DIFFERENCE IN THE SUCCESS RATE AND NO REGAIN OF WEIGHT. MORBIDITY IN THE EARLY POSTOPERATIVE PERIOD AND COMPLICATIONS IN THE LATER POSTOPERATIVE PERIOD WERE LIGHT AND MINIMAL. A DRAMATIC IMPROVEMENT OF COMMORBID CONDITIONS WAS OCCURED AFTER WEIGHT LOSS. FURTHERMORE NUTRITIONAL, METABOLIC AND BIOCHEMICAL ALTERATIONS DURING THE POSTOPERATIVE PERIOD WERE MINIMAL WITHOUT DEVELOPMENT OF NUTRIENT DEFICIENCIES. IT IS CONCLUDED THAT V.B.G. OR V.R.G. IS THE OPERATION OF CHOICE FOR THE TREATMENT OF MORBIDITY OBESE PATIENTS.Η ΠΑΡΟΥΣΑ ΕΡΓΑΣΙΑ ΠΕΡΙΛΑΜΒΑΝΕΙ ΣΤΟ ΓΕΝΙΚΟ ΜΕΡΟΣ ΤΗΣ ΕΚΤΕΝΗ ΑΝΑΦΟΡΑ ΣΤΗΝ ΑΙΤΙΟΠΑΘΟΓΕΝΕΙΑ ΚΑΙ ΤΗΝ ΕΠΙΔΗΜΙΟΛΟΓΙΑ ΤΗΣ ΚΛΙΝΙΚΑ ΣΟΒΑΡΗΣ ΠΑΧΥΣΑΡΚΙΑΣ ΚΑΘΩΣ ΚΑΙ ΣΤΙΣΣΥΝΤΗΡΗΤΙΚΕΣ ΚΑΙ ΧΕΙΡΟΥΡΓΙΚΕΣ ΜΕΘΟΔΟΥΣ ΑΝΤΙΜΕΤΩΠΙΣΗΣ ΤΗΣ ΝΟΣΟΥ. ΣΤΟ ΔΕΥΤΕΡΟ (ΕΙΔΙΚΟ) ΜΕΡΟΣ ΑΝΑΦΕΡΟΝΤΑΙ ΤΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΤΗΣ ΚΛΙΝΙΚΟΕΡΓΑΣΤΗΡΙΑΚΗΣ ΠΑΡΑΚΟΛΟΥΘΗΣΗΣ 35 ΑΣΘΕΝΩΝ ΠΟΥ ΥΠΟΒΛΗΘΗΚΑΝ ΣΕ ΚΑΘΕΤΗ ΔΙΑΜΕΡΙΣΜΑΤΟΠΟΙΗΣΗ. Η ΜΕΛΕΤΗ ΑΥΤΗ ΕΙΧΕ ΣΚΟΠΟ ΝΑ ΕΡΕΥΝΗΣΕΙ ΤΗΝ ΑΠΟΤΕΛΕΣΜΑΤΙΚΟΤΗΤΑ ΤΩΝ ΔΥΟ ΤΕΧΝΙΚΩΝ (MASON ΚΑΙ ECKHOUT) ΚΑΘΕΤΗΣ ΔΙΑΜΕΡΙΣΜΑΤΟΠΟΙΗΣΗΣ ΤΟΥ ΣΤΟΜΑΧΟΥ ΟΣΟΝ ΑΦΟΡΑ ΤΗ ΜΕΤΕΓΧΕΙΡΗΤΙΚΗ ΑΠΩΛΕΙΑ ΒΑΡΟΥΣ ΚΑΘΩΣ ΚΑΙ ΤΗ ΜΕΤΕΓΧΕΙΡΗΤΙΚΗ ΝΟΣΗΡΟΤΗΤΑ. ΕΠΙΠΛΕΟΝ ΔΙΕΡΕΥΝΗΘΗΚΕ Η ΕΞΕΛΙΞΗ ΤΗΣ ΣΥΝΟΔΟΥ ΤΗΣ ΠΑΧΥΣΑΡΚΙΑΣ ΝΟΣΗΡΟΤΗΤΑΣ ΚΑΙ ΙΔΙΑΙΤΕΡΑ ΟΙ ΑΙΜΑΤΟΛΟΓΙΚΕΣ ΒΙΟΧΗΜΙΚΕΣ ΚΑΙ ΛΟΙΠΕΣ ΜΕΤΑΒΟΛΙΚΕΣ ΜΕΤΑΒΟΛΕΣ ΚΑΙ ΔΙΑΤΑΡΑΧΕΣ ΜΕΤΑ ΤΗΝ ΑΠΩΛΕΙΑ ΒΑΡΟΥΣ ΟΠΩΣ ΠΡΟΕΚΥΨΕ ΑΠΟ ΤΗ ΜΕΛΕΤΗ ΑΥΤΗ ΚΑΙ ΟΙ ΔΥΟ ΤΕΧΝΙΚΕΣ (MASON ΚΑΙ ECKHOUT) ΠΡΟΚΑΛΟΥΝ ΙΣΟΔΥΝΑΜΗ ΚΑΙ ΑΚΡΩΣ ΙΚΑΝΟΠΟΙΗΤΙΚΗ ΑΠΩΛΕΙΑ ΒΑΡΟΥΣ Η ΟΠΟΙΑ ΣΥΝΟΔΕΥΕΤΑΙΑΠΟ ΔΡΑΜΑΤΙΚΗ ΒΕΛΤΙΩΣΗ ΤΗΣ ΣΥΝΟΔΟΥ ΝΟΣΗΡΟΤΗΤΑΣ. ΕΠΙΠΛΕΟΝ ΟΙ ΜΕΤΕΓΧΕΙΡΗΤΙΚΕΣ ΜΕΤΑΒΟΛΙΚΕΣ ΔΙΑΤΑΡΑΧΕΣ ΤΗΣ ΜΕΘΟΔΟΥ ΚΡΙΝΟΝΤΑΙ ΟΙ ΙΔΙΑΙΤΕΡΑ ΗΠΙΕΣ ΚΑΙ ΑΝΕΥ ΚΛΙΝΙΚΗΣ ΣΗΜΑΣΙΑΣ. ΓΙΑ ΤΟ ΛΟΓΟ ΑΥΤΟ Η ΕΝΙΣΧΥΜΕΝΗ ΚΑΘΕΤΗ ΔΙΑΜΕΡΙΣΜΑΤΟΠΟΙΗΣΗ ΤΟΥ ΣΤΟΜΑΧΟΥ ΑΠΟΤΕΛΕΙ ΜΕΘΟΔΟ ΕΚΛΟΓΗΣ ΓΙΑ ΤΗ ΧΕΙΡΟΥΡΓΙΚΗ ΑΝΤΙΜΕΤΩΠΙΣΗ ΤΗΣ ΚΛΙΝΙΚΑ ΣΟΒΑΡΗΣ ΠΑΧΥΣΑΡΚΙΑΣ
Adhesion molecules as targets for the treatment of neoplastic diseases
No full textThe quest for therapeutic specificity is implicit in all branches of medicine. In cancer treatment, cytotoxic agents, such as chemotherapy and radiotherapy, comprise the current therapeutic modality. Unfortunately, when used against most solid malignancies, their therapeutic indices are relatively low due to the significant damage they inflict on normal tissues. Furthermore, cure rates have remained essentially static over the last two decades. Specificity in killing neoplastic cells, while sparing healthy ones is therefore the only alternative approach, with several molecules qualifying as candidates for targeting therapy. Reduction of cell-cell and cell-matrix adhesion are, early tumorigenesis events also implicated in the invasive and metastatic process. The fact that abnormal adhesive marker expression is a feature commonly shared by most malignancies, along with its tendency to occur as both an early and late event in neoplastic development, makes these molecules potential candidates for antineoplastic targeted therapies. This review presents the perspectives of specific anti-adhesion molecule targeting as a possible therapeutic approach in neoplastic diseases
Measurement of damage growth in ultrasonic spot welded joint
No full textUltrasonic spot welding is a joining technique for thermoplastic composites with great potential regarding processing speed and cost. To investigate the damage tolerance and possible inherent damage arresting behavior of multi-spot welded joints, a technique is necessary to measure damage growth in the joints under cyclic loading. Visual inspection is not possible because the damage is not located on the outside surface and conventional techniques such as C-scan are not practical during a fatigue test because the specimen would have to be removed from the setup. This paper details a methodology for quantifying damage growth rates in singlespot welded joints using surface strain measurements made by Digital Image Correlation. This represents the first step towards developing a methodology for quantifying damage progression behavior in complex multi-spot welded joints.Structural Integrity & CompositesAerospace Structures & Computational Mechanic
Development and characterization of hybrid thin-ply composite materials
No full textThin-ply composites are recognized as a key solution for the manufacturing of high-performance composite structures due to the unique mechanical properties and the increased design versatility that they offer. They are obtained with state-of-the-art fiber spreading methods where high-count (6-24K filaments) tows of technical fibers (carbon, glass) are thinned by spreading into flat unidirectional tapes which are then combined with a polymer matrix to create pre-impregnated (prepregs) tapes of reduced thickness. In recent years, the industrialization of fiber spreading and impregnation processes enabled the large-scale production of homogenous thin-ply prepregs with thicknesses down to about 15μm per ply, which attracted the interest of the research community. However, the high production cost due to the complexity of the manufacturing methods and the inherent brittleness of thin-ply composites limit their wider adoption by the composites industry[1]. Fiber hybridization (i.e combining at least two types of fibers in a common matrix) is emerging as a promising approach for alleviating these drawbacks towards laminates with balanced characteristics in terms of mechanical properties and cost-efficiency. Currently, most studies on thin-ply hybrids employ simple interlayer (ply-by-ply) configurations mainly due to difficulties in manufacturing of more complex hybrid architectures[2]. However, simulation tools predict that notable improvements can be obtained from more complex intralayer (tow-by-tow) and intrayarn (fiber-by-fiber) hybrid architectures[3]. This work focuses on the study of existing fiber spreading methodologies, the development of equipment, and the optimization of composite processing at North Thin Ply Technology (NTPT) Renens, Switzerland, that allowed the manufacturing of hybrid composites with a high degree of fiber dispersion and controlled microstructure. Hybrid prepregs were produced by combining various ratios of dissimilar fibers following different processing routes. Composite laminates were manufactured and a versatile microstructural analysis tool was developed that enabled correlations between the manufacturing route, the resulting microstructural features describing the degree of co-dispersion, and the mechanical performance of the final part. Acknowledgments The research leading to these results has been performed within the framework of the HyFiSyn project and has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 765881. Delamination growth in fibre reinforced polymer composites is generally evaluated with experiments that have been standardized for quasi-static load conditions. These tests characterize unidirectional delamination growth in mode I (DCB), mode II (ELS or ENF) of mixed mode conditions (MMB). However, little attention is paid in literature to the applicability of these tests to in-service delamination problems that are generally characterized by planar delamination growth. In this study, the relation between planar delamination growth, induced by transverse quasi-static indentation loading, and these unidirectional delamination tests was investigated. To that aim, prior planar delamination growth tests reported in literature, performed at EPFL, were analysed to identify up to what extent this planar growth could be correlated to the concepts of strain energy release and strain energy density. Once this appeared to successful, an experimental setup was designed to measure the delamination boundary during the transverse indentation loading of planar delamination specimens made of nontransparent carbon fibre reinforced polymer composites. With that set-up, quasi-static and fatigue planar delamination growth experiments were performed, and delamination contours could be successfully captured. While the quasi-static tests revealed limited growth, evaluation with numerical simulations revealed that the indentation force required to extend the delamination quasi-statically would cause damage to the specimen. This is attributed to the increasing length of the delamination contour when delaminations expand, which is not the case with standard unidirectional specimen. With the fatigue tests, however, delamination growth was achieved, but interestingly enough two phases were observed; first the delamination propagated in a planar fashion, while at some point in time work did not exceed an apparent threshold. Instead of no growth, however, the delamination still increased but then in a transverse manner. What makes this study of particular interest, is that the strain energy density as criterion could capture the strain energy offered (work) along the entire delamination contour, while the strain energy release rate described the resistance to delamination growth. This latter observation is in agreement with the original concept employed by Griffith when he formulated the basis of linear elastic fracture mechanics. This presentation present the experiments performed, the analysis of results, and will conclude with a proposal how to relate standard unidirectional tests to planar growth, considering that these standard tests contain little to no information on transverse phenomena with respect to strain energy density (work) and strain energy release (dissipation).Aerospace Manufacturing Technologie
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