68 research outputs found
Data on phylogeography of the European roe deer (Capreolus capreolus)
No full textPresented data support the findings of the study on Pan-European phylogeography of the European roe deer (Capreolus capreolus
PLIS: A metabolomic response monitor to a lifestyle intervention study in older adults
No full textThe response to lifestyle intervention studies is often heterogeneous, especially in older adults. Subtle responses that may represent a health gain for individuals are not always detected by classical health variables, stressing the need for novel biomarkers that detect intermediate changes in metabolic, inflammatory, and immunity-related health. Here, our aim was to develop and validate a molecular multivariate biomarker maximally sensitive to the individual effect of a lifestyle intervention; the Personalized Lifestyle Intervention Status (PLIS). We used 1 H-NMR fasting blood metabolite measurements from before and after the 13-week combined physical and nutritional Growing Old TOgether (GOTO) lifestyle intervention study in combination with a fivefold cross-validation and a bootstrapping method to train a separate PLIS score for men and women. The PLIS scores consisted of 14 and four metabolites for females and males, respectively. Performance of the PLIS score in tracking health gain was illustrated by association of the sex-specific PLIS scores with several classical metabolic health markers, such as BMI, trunk fat%, fasting HDL cholesterol, and fasting insulin, the primary outcome of the GOTO study. We also showed that the baseline PLIS score indicated which participants respond positively to the intervention. Finally, we explored PLIS in an independent physical activity lifestyle intervention study, showing similar, albeit remarkably weaker, associations of PLIS with classical metabolic health markers. To conclude, we found that the sex-specific PLIS score was able to track the individual short-term metabolic health gain of the GOTO lifestyle intervention study. The methodology used to train the PLIS score potentially provides a useful instrument to track personal responses and predict the participant's health benefit in lifestyle interventions similar to the GOTO study.Pattern Recognition and Bioinformatic
La Vie Dans Les Plis
No full textLa vie dans les plis was premiered at The Firehouse Space (Brooklyn, NY) on June 9, 2014, by violinist Karen Rostron and pianist Mirna Lekić. The piece\u27s title is a reference to an eponimous collection of texts by Belgian author Henri Michaux. There is no direct connection between Michaux\u27s text and the structure of the piece. This choice of title, in addition to its great poetic beauty, is meant as an acknowledgement of my indebtedness to Henri Michaux\u27s writings, and, more generally, to Surrealist - and Surrealist-influenced - poetry, for revealing to me the artistic value of a bold exploration of the self
Phylogeography of European roe deer (Capreolus capreolus) in Central and Eastern Europe
No full textLink archiwalny https://depotuw.ceon.pl/handle/item/462
Sharing privacy-sensitive access to neuroimaging and genetics data: a review and preliminary validation
No full textThe growth of data sharing initiatives for neuroimaging and genomics represents an exciting opportunity to confront the “small N” problem that plagues contemporary neuroimaging studies while further understanding the role genetic markers play in the function of the brain. When it is possible, open data sharing provides the most benefits. However, some data cannot be shared at all due to privacy concerns and/or risk of re-identification. Sharing other data sets is hampered by the proliferation of complex data use agreements (DUAs) which preclude truly automated data mining. These DUAs arise because of concerns about the privacy and confidentiality for subjects; though many do permit direct access to data, they often require a cumbersome approval process that can take months. An alternative approach is to only share data derivatives such as statistical summaries—the challenges here are to reformulate computational methods to quantify the privacy risks associated with sharing the results of those computations. For example, a derived map of gray matter is often as identifiable as a fingerprint. Thus alternative approaches to accessing data are needed. This paper reviews the relevant literature on differential privacy, a framework for measuring and tracking privacy loss in these settings, and demonstrates the feasibility of using this framework to calculate statistics on data distributed at many sites while still providing privacy.This document is protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.Peer reviewe
Decentralized temporal independent component analysis: leveraging fMRI data in collaborative settings
No full textPeer reviewe
Wprowadzenie do problematyki koncepcji praw człowieka trzeciej generacji Karela Vasaka
No full textThe aim of the paper is to present the concept of the third generation of human rights. This concept was initially proposed in the late 1970’s by Karel Vasak. K. Vasak suggested that the three generations of human rights corresponded respectively to the three ideas proclaimed in the French revolution: liberty, equality and fraternity. The author has made an attempt to review the generations of human rights, with the particular emphasis of the third generation of human rights, also called the solidarity rights. The article contains historical and dogmatic analysis of solidarity rights, as well as discusses the fundamental assumptions of third generation of human rights. The conducted analysis allows to formulate a conclusion that the solidarity rights are necessary to protect such human values as: peace, development or healthy environment.Celem opracowania jest przedstawienie koncepcji praw człowieka trzeciej generacji. Koncepcję tą po raz pierwszy zaprezentował Karel Vasak pod koniec lat siedemdziesiątych ubiegłego wieku. Według K. Vasaka trzy generacje praw człowieka nawiązują do haseł Wielkiej Rewolucji Francuskiej: wolność, równość i braterstwo. Autor podjął próbę analizy poszczególnych generacji praw człowieka, ze szczególnym uwzględnieniem trzeciej generacji – praw solidarnościowych. Artykuł zawiera analizę historyczną i dogmatyczną praw solidarnościowych, a także omawia podstawowe założenia koncepcji praw człowieka trzeciej generacji. Przeprowadzona analiza pozwala na sformułowanie konkluzji, że prawa solidarnościowe są niezbędne dla ochrony takich wartości ludzkich, jak: pokój, rozwój, czy też zdrowe środowisko
Multiple testing in genome-wide association studies via hidden Markov models
No full textMotivation: Genome-wide association studies (GWAS) interrogate common genetic variation across the entire human genome in an unbiased manner and hold promise in identifying genetic variants with moderate or weak effect sizes. However, conventional testing procedures, which are mostly P-value based, ignore the dependency and therefore suffer from loss of efficiency. The goal of this article is to exploit the dependency information among adjacent single nucleotide polymorphisms (SNPs) to improve the screening efficiency in GWAS. Results: We propose to model the linear block dependency in the SNP data using hidden Markov models (HMMs). A compound decision-theoretic framework for testing HMM-dependent hypotheses is developed. We propose a powerful data-driven procedure [pooled local index of significance (PLIS)] that controls the false discovery rate (FDR) at the nominal level. PLIS is shown to be optimal in the sense that it has the smallest false negative rate (FNR) among all valid FDR procedures. By re-ranking significance for all SNPs with dependency considered, PLIS gains higher power than conventional P-value based methods. Simulation results demonstrate that PLIS dominates conventional FDR procedures in detecting disease-associated SNPs. Our method is applied to analysis of the SNP data from a GWAS of type 1 diabetes. Compared with the Benjamini-Hochberg (BH) procedure, PLIS yields more accurate results and has better reproducibility of findings. Conclusion: The genomic rankings based on our procedure are substantially different from the rankings based on the P -values. By integrating information from adjacent locations, the PLIS rankings benefit from the increased signal-to-noise ratio, hence our procedure often has higher statistical power and better reproducibility. It provides a promising direction in large-scale GWAS. © The Author 2009. Published by Oxford University Press. All rights reserved
Notes on Slavic Toponymic Antiquities of Novgorod Region
No full textThe article is devoted to etymological analysis of Slavic toponymical archaisms on Russian Northwest, such as Псижа, Плюсса, Плиска, Плеско, Пскова, Плюха etc. In opinion of author, these place names have relict features of structure and is formed from related steams ples-/plesk-/plьs-/plьsk-/plis-/plisk- with alternation of vowels and consonants.Работа выполнена при финансовой поддержке РГНФ (проект № 05-04-04120а)
Ассеманиев кодекс в контексте истории первого славянского перевода евангелия
No full textThe author points to the crucial role of the Codex Assemanianus in resolving the fundamental problem of Cyrillo-Methodian translation of the Gospels. The textological analysis of some readings reveals a deep understanding of the complexities of Greek Gospels and of its Semitic background. It also implies a certain exegetical independence of the Slavic version
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