138 research outputs found
Memory Study in The Danish Girl (2000) by David Ebershoff Through Voyant Text Mining Tools: A Digital Humanities (DH) Study: 1. Muhammad Awais 2. Adeel Khalid
No full textIn this digital era, the world has revolutionised its ways of extracting knowledge patterns based on diverse and large texts using a digital humanities (DH) approach and a range of digital text mining tools available to deconstruct and visualise literary texts. This paper attempts to explore the characters of the novel, ‘The Danish Girl’ by David Ebershoff, through the study of their individual or collective memories through Voyant, a text-mining digital tool for textual analysis. Analysis revealed knowledge patterns on memory in the text through the Voyant text mining tool, which recognizes repeating words and phrases and provides insights into the author\u27s language choices and how they relate to memory studies. It provided textual analysis and allowed data visualisation, collocations, and quantitative and qualitative analysis of the text. The study unveils the summary tool features of the overall corpus, cirrus, unique words, dense words, themes, and phrase tools using a digital humanities approach to text mining, underscoring the significance of digital tools in advancing our understanding of literature and memory
Weight Loss, Pathological Changes, and Inflammatory Effects from a Short-Term Ketogenic Diet in Overweight and Obese Men with Untreated Prostate Cancer on Active Surveillance
No full textBackground and aims: Active Surveillance (AS) is a favored strategy for the management of indolent prostate cancers (PCs). Overweight and obese men harbor an increased risk of cancer progression during AS. We aim to prospectively evaluate the feasibility and outcomes of a ketogenic diet (KD) weight-loss intervention in overweight men with PC.
Materials and methods: Men with PC and a BMI \u3e 25 kg/m2 undergoing AS were placed on an 8-week ad libitum KD program before a scheduled surveillance biopsy to assess the impact on clinical grade group (CGG). Blood ketone levels were tracked to ensure compliance. BMI, PSA, and inflammatory marker data (TNF-α, TNFR1, TNFR2, sICAM-1, sVCAM-1, IL-6, IL1-RA, CRP, and SAA) were collected before and after the KD intervention. A Shapiro-Wilk test was performed to assess the normality of all continuous study variables. Paired t-tests and Wilcoxon rank sum tests were utilized to compare normally and non-normally distributed study outcomes, respectively.
Results: Ten AS patients aged 62.1 (±5.4) years were enrolled with an average BMI of 31.7 kg/m2 (±11.8). Post-KD intervention mean blood ketone levels were 0.32 (±0.12) mmol/L with a mean BMI reduction of 7.4% (p \u3c 0.0003). There were no meaningful changes in PSA or inflammatory biomarkers (p \u3e 0.05). Nine patients completed re-biopsy following a KD with four patients showing no evidence of cancer; one downgraded to a lower CGG; two had unchanged CGG scores; and two had higher CGG scores compared to baseline.
Conclusions: Short-term KD interventions for BMI reduction are feasible in men undergoing AS for PC and may result in favorable pathological effects without inflammatory marker changes. Larger studies with longer follow-up are needed to explore whether KD-induced weight loss can improve clinical outcomes with AS in PC
A phase II trial of hepatic ablation of metastases to modulate and enhance immunotherapy response in non-small cell lung cancer (HAMMER-NSCLC)
No full textSimulation of an HDR Boost with Stereotactic Proton versus Photon Therapy in Prostate Cancer: A Dosimetric Feasibility Study
No full textPurpose/objectives: To compare the dose escalation potential of stereotactic body proton therapy (SBPT) versus stereotactic body photon therapy (SBXT) using high-dose rate prostate brachytherapy (HDR-B) dose-prescription metrics.
Patients and methods: Twenty-five patients previously treated with radiation for prostate cancer were identified and stratified by prostate size (≤ 50cc; n = 13, \u3e 50cc; n = 12). Initial CT simulation scans were re-planned using SBXT and SBPT modalities using a prescription dose of 19Gy in 2 fractions. Target coverage goals were designed to mimic the dose distributions of HDR-B and maximized to the upper limit constraint for the rectum and urethra. Dosimetric parameters between SBPT and SBXT were compared using the signed-rank test and again after stratification for prostate size (≤ 50cm3 and \u3e50cm3) using the Wilcoxon rank test.
Results: Prostate volume receiving 100% of the dose (V100) was significantly greater for SBXT (99%) versus SBPT (96%) (P ≤ 0.01), whereas the median V125 (82% vs. 73%, P \u3c 0.01) and V200 (12% vs. 2%, P \u3c 0.01) was significantly greater for SBPT compared to SBXT. Median V150 was 49% for both cohorts (P = 0.92). V125 and V200 were significantly correlated with prostate size. For prostates \u3e 50cm3, V200 was significantly greater with SBPT compared to SBXT (14.5% vs. 1%, P = 0.005), but not for prostates 50cm3 (9% vs 4%, P = 0.11). Median dose to 2cm3 of the bladder neck was significantly lower with SBPT versus SBXT (9.6 Gy vs. 14 Gy, P \u3c 0.01).
Conclusion: SBPT and SBXT can be used to simulate an HDR-B boost for locally advanced prostate cancer. SBPT demonstrated greater dose escalation potential than SBXT. These results are relevant for future trial design, particularly in patients with high risk prostate cancer who are not amenable to brachytherapy.
Keywords: brachytherapy; prostate cancer; proton therapy; stereotactic radiation therapy
Cross genre author profilling using syntactic N-Grams
No full textTesis (Maestría en Ciencias de la Computación), Instituto Politécnico Nacional, CIC, 2017, 1 archivo PDF, (95 páginas). tesis.ipn.m
Cross-Genre Author Profile Prediction Using Stylometry-Based Approach Notebook for PAN at CLEF 2016
No full textAbstract.Author profiling task aims to identify different traits of an author by analyzing his/her written text. This study presents a Stylometry-based approach for detection of author traits (gender and age) for cross-genre author profiles. In our proposed approach, we used different types of stylistic features including 7 lexical features, 16 syntactic features, 26 character-based features and 6 vocabulary richness (total 56 stylistic features). On the training corpus, the proposed approach obtained promising results with an accuracy of 0.787 for gender, 0.983 for age and 0.780 for both (jointly detecting age and gender). On the test corpus, proposed system gave an accuracy of 0.576 for gender, 0.371 for age and 0.256 for both
Label-free electrochemical aptasensor for the detection of SARS-CoV-2 spike protein based on carbon cloth sputtered gold nanoparticles
No full textThe proliferation and transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or the (COVID-19) disease, has become a threat to worldwide biosecurity. Therefore, early diagnosis of COVID-19 is crucial to combat the ongoing infection spread. In this study we propose a flexible aptamer-based electrochemical sensor for the rapid, label-free detection of SARS-CoV-2 spike protein (SP). A platform made of a porous and flexible carbon cloth, coated with gold nanoparticles, to increase the conductivity and electrochemical performance of the material, was assembled with a thiol functionalized DNA aptamer via S–Au bonds, for the selective recognition of the SARS-CoV-2 SP. The various steps for the sensor preparation were followed by using scanning electron microscopy, cyclic voltammetry and differential pulse voltammetry (DPV). The proposed platform displayed good mechanical stability, revealing negligible changes on voltammetric responses to bending at various angles. Quantification of SARS-CoV-2 SP was performed by DPV and chronopotentiometry (CP), exploiting the changes of the electrical signals due the [Fe(CN)6]3-/4- redox probe, when SARS-CoV-2 SP binds to the aptamer immobilized on the electrode surface. Current density, in DPV, and square root of the transition time, in CP, varied linearly with the log[ SARS-CoV-2 SP], providing lower limits of detection (LOD) of 0.11 ng/mL and 37.8 ng/mL, respectively. The sensor displayed good selectivity, repeatability, and was tested in diluted human saliva, spiked with different SARS-CoV-2 SP concentrations, providing LODs of 0.167 ng/mL and 46.2 ng/mL for DPV and CP, respectively
The Impact of Environmental Change and Water Conservation on Dryland Groundwater Resources in Northern Egypt: Modeling Aquifer Response Using Sparse Data
No full textPlease contact the author with any questions. A compressed tar.b2z file is attached with the groundwater model input files.Wadi El Naturn, located in the Western Desert in northern Egypt, has been subject to significant groundwater degradation since the 1990s, attributed primarily to agricultural development. Information required to diagnose the drivers of groundwater degradation and assess management options in dryland environments like Wadi El Natrun is however, frequently sparse. This research presents an approach for modeling the impacts of dryland environmental change on groundwater in the context of sparse data. A focus is placed on understanding the potential impacts of conservation strategies in the context of climate change. Water use, hydrostratigraphic and groundwater flow data were collected from literature, monitoring records, satellite imagery and a survey of local landholders. MODFLOW-NWT was used to model the multi-layer aquifer system, and algorithms were developed in R to create realizations of groundwater recharge, and well-pumping at a monthly time-step from 1957 to 2011. The model was deemed to be reasonably capable of capturing the cumulative impact of environmental change over this historical period. A risk assessment approach was then used to assess the impact of climate change and conservation-focused management scenarios on groundwater locally over a 50-year future planning horizon. The optimization of irrigation systems and increased cultivation of drought/salt tolerant crops have the potential to significantly reduce the risk of groundwater depletion compared to an across-the-board 20% water use reduction scenario. The influence of groundwater pumping also outweighed that of climate change, and the most vulnerable water users/ecosystem were found to be the most exposed to groundwater degradation.Master of Applied Science (MASc
Global navigation of Lithium in water bodies and emerging human health crisis
No full textThe production of lithium (Li) increased by 256% in recent years due to unprecedented demands from technological industries. Intensive harvesting poses serious impacts on the sustainability of Li production. Herein, we address the global Li cycle and predict the peak production to reach 740000 million tons in 2041. Global Li accumulation in water bodies is mapped, and the consequences on human health of a wide range (20 mg L−1) of Li concentrations in drinking water are explored. The implications to human health of Li exposure remains unresolved and needs further investigation. There are still no recommendations on safe limits of Li in drinking water for humankind. In conclusion, there is an emergency call to health governing bodies, environmental protection agencies and scientific communities for urgent efforts on sustainable production of Li and identify their thresholds levels in drinking water to minimize the emerging consequences of Li on humans.This article is published as Adeel, M., Zain, M., Shakoor, N. et al. Global navigation of Lithium in water bodies and emerging human health crisis. npj Clean Water 6, 33 (2023). https://doi.org/10.1038/s41545-023-00238-w. © The Author(s) 2023.This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
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