79 research outputs found
Identification of Novel BACE-1 Inhibitors through an Advanced Structure-Based Virtual Screening Protocol.
No full textAn Advanced Multiple Receptor Conformations Virtual Ligand Screening Protocol for the Identification of Novel BACE-1 Inhibitors
No full textDevelopment and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments
No full textIn this study, we report on a virtual ligand screening protocol optimized to identify fragments endowed with activity at multiple targets. Thanks to this protocol, we were able to identify a fragment that displays activity in the low-micromolar range at both β-secretase 1 (BACE-1) and glycogen synthase kinase 3β (GSK-3β). These two structurally and physiologically unrelated enzymes likely contribute, through different pathways, to the onset of Alzheimer′s disease (AD). Therefore, their simultaneous inhibition holds great potential in exerting a profound effect on AD. In perspective, the strategy outlined herein can be adapted to other target combinations.</p
Content name resolution service implementation for cache and forward network architecture
No full textCache aNd Forward (CNF) is a proposed architecture for content delivery services in the future Internet. The CNF architecture takes advantage of reductions in storage to design a network that directly addresses the mobile content delivery problem. The CNF architecture uses a content name resolution service protocol, along with a reliable hop-by-hop transport protocol, storage aware routing protocol in place of end-to-end TCP for reliable delivery of large files. This thesis presents the algorithms proposed for a distributed name resolution protocol and design and experimental evaluation of the protocol on ORBIT in context of a multi-hop wireless access network scenario. The protocol is designed using hashing technique such that when a host queries for a file, the name service will be triggered and will return the addresses of nodes that cache the file. Since our architecture is about caching and forwarding large content files, enabling hosts to retrieve files from the network and not necessarily from the origin server, we need to uniquely identify the files. To that effect, we propose to identify a file using a unique content identifier (CID) where CID is obtained by a one way hashing (SHA1) on the content itself. The aim here is to optimize selection of cache location and serve the host with the file from the nearest location. If the selected cache location is determined to be temporarily degraded, either due to poor channel conditions or mobility, the protocol uses multiple hash technique to provide alternate cache locations and the decision is based on the ETT metric provided by the routing protocol. The CNRS protocol over multi-hop 802.11 access networks with CNF routers has been implemented as a real-time proof-of-concept prototype on the ORBIT testbed. Baseline results for CNRS with hop-by-hop transport show that content based CNF network architecture performs better than TCP/IP stack. Using different content distributions, we have shown that multiple hashing, popularity based and location based caching provide significant gains over the baseline algorithm.M.S.Includes bibliographical referencesby Puneet Katari
Determination of the octanol-water partition coefficient of indolicidin and indolicidin45 using micellar electrokinetic chromatography
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Unsteady MHD nanofluid flow past a stretching sheet with Stefan blowing effect: HAM solution
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Influence of g–jitter on the Rayleigh-Bénard convection in nanofluids with internal heat source
No full textThe Roar of the Resilient
No full textAs undergraduate students, the fear and uncertainty of our future and career comes full swing. Anxiety seeped its way into my mind during my first year of university. I knew that given the criminal justice systems impact on my family, a career in criminology was not going to be an easy task, but I chose to go against the grain and try it anyway. Criminology was interesting to me; I sought to know more about the process, I needed to know more about the system. At KPU, I had the opportunity to thrive and absorb invaluable lessons. Through the Co-operative Education Program, I had the opportunity to work with the Canada Border Services, Citizenship and Immigration, and WorkSafeBC. My experiences included enforcing legislation, reviewing immigration and refugee files, and building a professional network. I learned about the politics and systematic issues that surrounded these organizations, and the value of a job that I couldn’t wait to wake up to. My last co-op term was with WorkSafeBC, in the Field Investigations Department. I stepped into my office on my first day of work, not knowing I’d never want to leave. The autonomy and creative process I had over my workload was insurmountable. I decided within my first month that this was where I belonged, and my sole purpose became to do anything and everything I could to stay. Today, I stand as a published author, BA Criminology candidate, and a permanent, full-time, WorkSafeBC employee. I learned humility, I cultivated strength, I bleed resilience, and radiate tenacity. This presentation will discuss the avenues of support and opportunity that students have here at KPU and the many ways by which students can maximize their education. I will discuss my experience at KPU and as an employee of WorkSafeBC, in the Field Investigations Department. More specifically, students will walk away learning some practical information on the processes of conducting Internet investigations using open source media
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