4,191 research outputs found
KUTV news featurette on cloning, molecular genetics, and disease aired November 9, 1997
No full textvideoThis 3 minutes, 1 second video clip from Salt Lake City\u27s KUTV, Channel 2 features a short interview with Mario Capecchi concerning cloning and its use in molecular genetics and the study of human diseases
KUTV EXTRA Episode 5: Teton Dam Revisited, On The Street
No full textVideo recording of the fifth KUTV EXTRA episode (color, sound, 28 minutes and 47 seconds), originally on U-Matic tape. It aired on June 6, 1977, and had two segments. Teton Dam Revisited [0:00:00]: This EXTRA clip shows an excerpt of Channel 2\u27s program A Day We Won\u27t Forget by Sandy Gilmore. It includes footage and interviews exploring the damage and rebuilding of the dam after the massive accident. On The Street [0:11:57]: This portion is in conjunction with the Teton Dam episode as it interviews people on the streets about whether the dam should be rebuilt and how people have been coping with the disaster
Local television news clips for June 14, 1994 featuring Mario Capecchi
No full textvideoThis is a compilation of news clips from Salt Lake City\u27s four major commercial television stations (Channels 2, 4, 5, and 13) lasting a total of 2 minutes, 59 seconds. The topic is Capecchi\u27s winning of the General Motors Corporation\u27s Alfred P. Sloan Jr. Prize for Outstanding Basic Science Contributions to Cancer Research. The award was given for Capecchi\u27s development of transgenic mice and their role in indentifying the genetic roots of cancer cells
KUTV channel 2 news station. Cars fill the parking lot in front of the building.
No full textBlack and white photo showing KUTV channel 2 news station with automobiles parked in front of the building, taken in 196
Focus is Key to Success: A Focal Loss Function for Deep Learning-Based Side-Channel Analysis
No full textThe deep learning-based side-channel analysis represents one of the most powerful side-channel attack approaches. Thanks to its capability in dealing with raw features and countermeasures, it becomes the de facto standard approach for the SCA community. The recent works significantly improved the deep learning-based attacks from various perspectives, like hyperparameter tuning, design guidelines, or custom neural network architecture elements. Still, insufficient attention has been given to the core of the learning process - the loss function. This paper analyzes the limitations of the existing loss functions and then proposes a novel side-channel analysis-optimized loss function: Focal Loss Ratio (FLR), to cope with the identified drawbacks observed in other loss functions. To validate our design, we 1) conduct a thorough experimental study considering various scenarios (datasets, leakage models, neural network architectures) and 2) compare with other loss functions used in the deep learning-based side-channel analysis (both “traditional” ones and those designed for side-channel analysis). Our results show that FLR loss outperforms other loss functions in various conditions while not having computational overhead like some recent loss function proposals.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Cyber Securit
Cultural aspects of multi-channel customer management: A case study in Italy
Get PDFChannel management is one of CRM systems component much influenced by the behaviour of customers in relation to its implementation and use. The consumers’ behaviours, preferences, perceptions and expectations are crucial for the implementation and use of channel management. Customers’ contact with the organization’s multi-channels can occur at several touch points throughout the customer lifecycle. Customers’ behaviours may be differentiated according to the individual or micro level, but it might also differ at an ecological or macro level of analysis (Ramaseshan et al., 2006). In this paper the author has conducted a case study in a multinational organization in Italy to analyze customers’ behaviours at a macro level and customers channel choices, through out the customer lifecycle. The author has used a content analysis technique to define the themes of the case study and then used the Structurational Analysis model by Ali and Brooks, (2008) to identify the cultural values dimensions (Ali, et al. 2008a) that influence multi-channel customer management in Italy. The research findings highlight the cultural dimensions, which should be considered while adopting multi-channel customer strategy. Also, the research findings encourage the articulation of situated cultural approach to study cultural impact within IS discipline as alternative approach than predefined culture archetype
Dispersive to nondispersive transition in the plane wake and channel flows
No full textBy varying the wavenumber over a large and finely discretized interval of values, we analyse the phase and group velocity of linear three-dimensional travelling waves both in the plane wake and channel flows to get the transition between dispersive and non-dispersive behaviour. The dispersion relation is computed from the Orr-Sommerfeld and Squire eigenvalue problem by observing the least stable mode, see figure 2, panels (a,b) and the comparison with [1, 2, 4–11, 15, 16]. The group velocity vg is also shown. The Reynolds number varies in the 20-100, 1000-8000 ranges for the wake and the channel flow, respectively, while we consider wavenumbers in the range 0.1-10. The wake basic flow consists of the first two orders of the Navier-Stokes matched asymptotic expansion described in [3, 13, 14]. At low wavenumbers we observe a dispersive behaviour where the phase speed and the group velocity substantially differ. The relevant perturbed solution is amenable to the typical solution belonging to the left branch of the eigenvalue spectrum, see the two examples shown in figure 1 (channel flow: Re = 6000; k = 1; wake Re = 100; k = 0:7). By rising the wave number value, we observe a sharp transition from the dispersive to the nondispersive regime. This transition is located at a critical wave number kd which is a function of the Reynolds number Re, the wave angle _, and the wake downstream observation point x0. Precisely, kd increases with Re and decreases with _ for the wake flow, while these trends are reversed for the channel flow, see tables 1,2. Beyond the wavenumber threshold, the observed least-stable mode belongs to the right branch of the spectrum. The asymptotic solutions in the dispersive region are wall modes for the channel flow , and in-wake modes for the wake flow. This means that, for both the flows, the dispersive behaviour is related to perturbations with high momentum variations (high vorticity) in correspondence to the base flow high-shear region. On the contrary, if k > kd the solutions are central modes for the channel case, and out-of-wake modes for the wake flow. In these cases, the disturbance has high variations outside the base flow high-shear region. To understand the physical mechanism of the dispersive-nondispersive transition we focused on time variation of the wave kinetic energy associated to the convective transport. Figure 2 (c,d) shows the convective term as a function of the wavenumber for the two least stable modes. We observe that the dispersive-nondisperive transition allows waves k > kd to keep the lowest possible temporal variation of kinetic energy, i.e. the lowest decay. This remains true also when all the other more stable modes are considered. In practice nondispersive waves maintain their convective energy with k
The response of the tandem pore potassium channel TASK-3 (K2P9.1) to voltage : gating at the cytoplasmic mouth
Get PDFAlthough the tandem pore potassium channel TASK-3 is thought to open and shut at its
selectivity filter in response to changes of extracellular pH, it is currently unknown whether the
channel also shows gating at its inner, cytoplasmic mouth through movements of membrane
helices M2 and M4.We used two electrode voltage clamp and single channel recording to show
that TASK-3 responds to voltage in a way that reveals such gating. In wild-type channels, Popen
was very low at negative voltages, but increased with depolarisation. The effect of voltage was
relatively weak and the gating charge small, ∼0.17.Mutants A237T (in M4) and N133A (in M2)
increased Popen at a given voltage, increasing mean open time and the number of openings per
burst. In addition, the relationship between Popen andvoltagewas shifted to lesspositive voltages.
Mutation of putative hinge glycines (G117A, G231A), residues that are conserved throughout
the tandem pore channel family, reduced Popen at a given voltage, shifting the relationship
with voltage to a more positive potential range. None of these mutants substantially affected
the response of the channel to extracellular acidification. We have used the results from single
channel recording to develop a simple kinetic model to show how gating occurs through two
classes of conformation change, with two routes out of the open state, as expected if gating
occurs both at the selectivity filter and at its cytoplasmic mouth
Direct numerical simulations of drag reduction in turbulent channel flow over bio-inspired herringbone riblet-texture
No full textThe use of drag reducing surface textures is a promising passive method to reduce fuel consumption. Probably most wellknown is the utilisation of shark-skin inspired ridges or riblets parallel to the mean flow. They can reduce drag up to 10%. Recently another bio-inspired texture based on bird flight feather riblets has been proposed. It differs from the standard riblets in two ways. First, the riblets are arranged in a converging/diverging or herringbone pattern. Second, the riblet height or groove depth changes gradually. Drag reductions as high as 20% have been claimed [2]. The objective of the present work is to study the drag reducing properties and mechanisms of this texture. To that purpose Direct Numerical Simulations (DNSs) of turbulent plane channel flow have been performed. Structured roughness has been applied to both walls and several geometric parameters have been varied. Marginal drag reductions on the order of 2.5% and significant drag increases well beyond 100% were found. The latter is attributed to a strong secondary flow that mixes momentum through the whole channel. In future optimization studies we might look for conditions at which secondary motions affect the near-wall cycle of turbulence only
Preparing for 1991 Utah Pride March
No full textColor photograph of marchers preparing pride flags for the 1991 Gay and lesbian pride march news truck from Channel 2 KUTV Utah in backgroun
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