112,796 research outputs found
Modular Synthesis of α,α-Diaryl α-Amino Esters via Bi(V)-Mediated Arylation/SN2-Displacement of Kukhtin–Ramirez Intermediates
No full textWe report a concise and modular approach to α,α-diaryl α-amino esters from readily available α-keto esters. This mild, one-pot protocol proceeds via ketone umpolung, with in situ formation of a Kukhtin-Ramirez intermediate preceding sequential electrophilic arylation by Bi(V) and SN2 displacement by an amine. The methodology is compatible with a wide range of anilines and primary amines - including derivatives of drugs and proteinogenic amino acids - Bi(V) arylating agents, and α-keto ester substrates
Modular Synthesis of α,α-Diaryl α‑Amino Esters via Bi(V)-Mediated Arylation/S<sub>N</sub>2‑Displacement of Kukhtin–Ramirez Intermediates
No full textWe report a concise and modular approach to α,α-diaryl
α-amino esters from readily available α-keto esters. This
mild, one-pot protocol proceeds via ketone umpolung, with in situ formation of a Kukhtin–Ramirez intermediate
preceding sequential electrophilic arylation by Bi(V) and SN2 displacement by an amine. The methodology is compatible with a
wide range of anilines and primary amines - including derivatives
of drugs and proteinogenic amino acids - Bi(V) arylating agents, and
α-keto ester substrates
Modular Synthesis of α,α-Diaryl α‑Amino Esters via Bi(V)-Mediated Arylation/S<sub>N</sub>2‑Displacement of Kukhtin–Ramirez Intermediates
No full textWe report a concise and modular approach to α,α-diaryl
α-amino esters from readily available α-keto esters. This
mild, one-pot protocol proceeds via ketone umpolung, with in situ formation of a Kukhtin–Ramirez intermediate
preceding sequential electrophilic arylation by Bi(V) and SN2 displacement by an amine. The methodology is compatible with a
wide range of anilines and primary amines - including derivatives
of drugs and proteinogenic amino acids - Bi(V) arylating agents, and
α-keto ester substrates
Modular Synthesis of α,α-Diaryl α‑Amino Esters via Bi(V)-Mediated Arylation/S<sub>N</sub>2‑Displacement of Kukhtin–Ramirez Intermediates
No full textWe report a concise and modular approach to α,α-diaryl
α-amino esters from readily available α-keto esters. This
mild, one-pot protocol proceeds via ketone umpolung, with in situ formation of a Kukhtin–Ramirez intermediate
preceding sequential electrophilic arylation by Bi(V) and SN2 displacement by an amine. The methodology is compatible with a
wide range of anilines and primary amines - including derivatives
of drugs and proteinogenic amino acids - Bi(V) arylating agents, and
α-keto ester substrates
Modular Synthesis of α,α-Diaryl α‑Amino Esters via Bi(V)-Mediated Arylation/S<sub>N</sub>2‑Displacement of Kukhtin–Ramirez Intermediates
No full textWe report a concise and modular approach to α,α-diaryl
α-amino esters from readily available α-keto esters. This
mild, one-pot protocol proceeds via ketone umpolung, with in situ formation of a Kukhtin–Ramirez intermediate
preceding sequential electrophilic arylation by Bi(V) and SN2 displacement by an amine. The methodology is compatible with a
wide range of anilines and primary amines - including derivatives
of drugs and proteinogenic amino acids - Bi(V) arylating agents, and
α-keto ester substrates
Modular Synthesis of α,α-Diaryl α‑Amino Esters via Bi(V)-Mediated Arylation/S<sub>N</sub>2‑Displacement of Kukhtin–Ramirez Intermediates
No full textWe report a concise and modular approach to α,α-diaryl
α-amino esters from readily available α-keto esters. This
mild, one-pot protocol proceeds via ketone umpolung, with in situ formation of a Kukhtin–Ramirez intermediate
preceding sequential electrophilic arylation by Bi(V) and SN2 displacement by an amine. The methodology is compatible with a
wide range of anilines and primary amines - including derivatives
of drugs and proteinogenic amino acids - Bi(V) arylating agents, and
α-keto ester substrates
Modular Synthesis of α,α-Diaryl α‑Amino Esters via Bi(V)-Mediated Arylation/S<sub>N</sub>2‑Displacement of Kukhtin–Ramirez Intermediates
No full textWe report a concise and modular approach to α,α-diaryl
α-amino esters from readily available α-keto esters. This
mild, one-pot protocol proceeds via ketone umpolung, with in situ formation of a Kukhtin–Ramirez intermediate
preceding sequential electrophilic arylation by Bi(V) and SN2 displacement by an amine. The methodology is compatible with a
wide range of anilines and primary amines - including derivatives
of drugs and proteinogenic amino acids - Bi(V) arylating agents, and
α-keto ester substrates
Modular Synthesis of α,α-Diaryl α‑Amino Esters via Bi(V)-Mediated Arylation/S<sub>N</sub>2‑Displacement of Kukhtin–Ramirez Intermediates
No full textWe report a concise and modular approach to α,α-diaryl
α-amino esters from readily available α-keto esters. This
mild, one-pot protocol proceeds via ketone umpolung, with in situ formation of a Kukhtin–Ramirez intermediate
preceding sequential electrophilic arylation by Bi(V) and SN2 displacement by an amine. The methodology is compatible with a
wide range of anilines and primary amines - including derivatives
of drugs and proteinogenic amino acids - Bi(V) arylating agents, and
α-keto ester substrates
Modular Synthesis of α,α-Diaryl α‑Amino Esters via Bi(V)-Mediated Arylation/S<sub>N</sub>2‑Displacement of Kukhtin–Ramirez Intermediates
No full textWe report a concise and modular approach to α,α-diaryl
α-amino esters from readily available α-keto esters. This
mild, one-pot protocol proceeds via ketone umpolung, with in situ formation of a Kukhtin–Ramirez intermediate
preceding sequential electrophilic arylation by Bi(V) and SN2 displacement by an amine. The methodology is compatible with a
wide range of anilines and primary amines - including derivatives
of drugs and proteinogenic amino acids - Bi(V) arylating agents, and
α-keto ester substrates
Modular Synthesis of α,α-Diaryl α‑Amino Esters via Bi(V)-Mediated Arylation/S<sub>N</sub>2‑Displacement of Kukhtin–Ramirez Intermediates
No full textWe report a concise and modular approach to α,α-diaryl
α-amino esters from readily available α-keto esters. This
mild, one-pot protocol proceeds via ketone umpolung, with in situ formation of a Kukhtin–Ramirez intermediate
preceding sequential electrophilic arylation by Bi(V) and SN2 displacement by an amine. The methodology is compatible with a
wide range of anilines and primary amines - including derivatives
of drugs and proteinogenic amino acids - Bi(V) arylating agents, and
α-keto ester substrates
- …
