103,925 research outputs found
Prof. T. de Koning
No full textFormat: TIFF; Size: 8.29 MB; Dimensions: 2478 x 3505 pixels; Resolution: 300 ppiFarewell of Prof. T. de Koning, who was appointed as rector at the University of Venda. The rector of RAU, prof. J.P. de Lange, is on the right
Prof. T. de Koning
No full textFormat: TIFF; Size: 8.29 MB; Dimensions: 2478 x 3505 pixels; Resolution: 300 ppiFarewell of Prof. T. de Koning, who was appointed as rector at the University of Venda. The rector of RAU, prof. J.P. de Lange, is on the right
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Question XII, (posée par M. J. Boyer). Entre Germinal an XI et le premier Codex a-t-il été publié des pharmacopées régionales dans les départements soumis à la loi française ?
No full textWittop Koning Dirk Arnold. Question XII, (posée par M. J. Boyer). Entre Germinal an XI et le premier Codex a-t-il été publié des pharmacopées régionales dans les départements soumis à la loi française ? . In: Revue d'histoire de la pharmacie, 40ᵉ année, n°132, 1952. p. 329
The Tourism Industry under Crisis: The Struggle of Small Tourism Enterprises in Yogyakarta (Indonesia)
No full textDahles, H. [Promotor]Koning, J.B.M. [Copromotor
Removing celiac disease-related gluten proteins from bread wheat while retaining technological properties: a study with Chinese Spring deletion lines
No full textAbstract Background Gluten proteins can induce celiac disease (CD) in genetically susceptible individuals. In CD patients gluten-derived peptides are presented to the immune system, which leads to a CD4+ T-cell mediated immune response and inflammation of the small intestine. However, not all gluten proteins contain T-cell stimulatory epitopes. Gluten proteins are encoded by multigene loci present on chromosomes 1 and 6 of the three different genomes of hexaploid bread wheat (Triticum aestivum) (AABBDD). Results The effects of deleting individual gluten loci on both the level of T-cell stimulatory epitopes in the gluten proteome and the technological properties of the flour were analyzed using a set of deletion lines of Triticum aestivum cv. Chinese Spring. The reduction of T-cell stimulatory epitopes was analyzed using monoclonal antibodies that recognize T-cell epitopes present in gluten proteins. The deletion lines were technologically tested with respect to dough mixing properties and dough rheology. The results show that removing the α-gliadin locus from the short arm of chromosome 6 of the D-genome (6DS) resulted in a significant decrease in the presence of T-cell stimulatory epitopes but also in a significant loss of technological properties. However, removing the ω-gliadin, γ-gliadin, and LMW-GS loci from the short arm of chromosome 1 of the D-genome (1DS) removed T-cell stimulatory epitopes from the proteome while maintaining technological properties. Conclusion The consequences of these data are discussed with regard to reducing the load of T-cell stimulatory epitopes in wheat, and to contributing to the design of CD-safe wheat varieties.</p
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Contracting welfare-to-work services: use and usefulness
No full textThis paper contributes to the broad literature on public services contracting in two ways: We provide an empirical analysis of contracting decisions in the provision of welfare-to-work (WTW) services, and we explicitly model two forms of external provision of WTW services by municipalities. We estimate both the WTW-contracting decisions of Dutch municipalities and their impact on the performance, measured as the fraction of Social Assistance recipients. The two forms of external provision are (1) Contracting with other municipalities and/or (2) Contracting-out services to private providers. Our findings suggest that contracting decisions are predominantly driven by cost considerations, both for the decision to contract with other municipalities and the share of contracting out to private providers. Municipalities with low WTW budgets or facing budget constraints are more likely to contract with external parties – presumably this reduces their costs and the risk of future budget deficits. We do not find contracting decisions to affect the performance of municipalities, measured as the use, inflow or outflow out of the SA scheme. From this alone, however, we cannot conclude that both the three provision modes are equally cost-effective too, as external provision may be less costly.
Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease
No full textGluten proteins from wheat can induce celiac disease (CD) in genetically susceptible individuals. Specific gluten peptides can be presented by antigen presenting cells to gluten-sensitive T-cell lymphocytes leading to CD. During the last decades, a significant increase has been observed in the prevalence of CD. This may partly be attributed to an increase in awareness and to improved diagnostic techniques, but increased wheat and gluten consumption is also considered a major cause. To analyze whether wheat breeding contributed to the increase of the prevalence of CD, we have compared the genetic diversity of gluten proteins for the presence of two CD epitopes (Glia-a9 and Glia-a20) in 36 modern European wheat varieties and in 50 landraces representing the wheat varieties grown up to around a century ago. Glia-a9 is a major (immunodominant) epitope that is recognized by the majority of CD patients. The minor Glia-a20 was included as a technical reference. Overall, the presence of the Glia-a9 epitope was higher in the modern varieties, whereas the presence of the Glia-a20 epitope was lower, as compared to the landraces. This suggests that modern wheat breeding practices may have led to an increased exposure to CD epitopes. On the other hand, some modern varieties and landraces have been identified that have relatively low contents of both epitopes. Such selected lines may serve as a start to breed wheat for the introduction of ‘low CD toxic’ as a new breeding trait. Large-scale culture and consumption of such varieties would considerably aid in decreasing the prevalence of C
Flow beneath inland navigation vessels
No full textGrowing transportation rates and the subsequent growth in inland waterway transport have led to an increase in inland vessel sizes and draught. Due to the fluctuating water levels on rivers and these increasing draughts, the distance between the river bed and the ships are decreasing. Rijkswaterstaat wants to know the effects of sailing at these small underkeel clearances on river beds and ship manoeuvrability. In order to quantify these effects, more knowledge about the flow field beneath sailing vessels is required, as well as the effect of the flow field on erosion of bed material. Currently no methods exist to determine the flow field beneath vessels, only a few formulations for a single maximum velocity value are available, but these are not applicable at small underkeel clearances (h / T < 1.25). Also the effect on the river bed is fairly unknown. To quantify the different effects of small underkeel clearances on the flow field physical model tests (with a length scale of 30) have been performed at Deltares. During these experiments a ship was towed through the flume, and flow velocities and pressures on the bed were measured, as well as forces on the ship. Additional experiments have been performed to investigate the effect on a moveable bed with different bed forms. From the experiments, it was found that the most important parameters that influence the flow field beneath the keel are the bow shape and the underkeel clearance. Barge bows force more flow underneath the keel than conventional bows, and this results in higher bed velocities. Decreasing keel clearances also result in significantly higher velocities at the bed. However, for very small underkeel clearances the boundary layer on the ship will interact with the boundary layer on the bed. This results in flow blockage underneath the keel. As a result, the flow needs to divert to the sides, and the velocities underneath the keel decrease. The diversion of the flow to the sides is also known as the fanning-out effect. This effect has definitely been proved by the measurements from the experiments. The effect (transverse velocities) increases with decreasing keel clearance (due to boundary layer interaction) and also increases with increasing ship widths. During the experiments, erosion of bed material was clearly observed, and its effect increased with decreasing keel clearance. However, the underkeel clearance needs to be very small (h /UKC < 1.1) to give significant bed erosion. Due to the fanning-out effect and turbulence fluctuations, most sediment transport occurred immediately alongside the vessel, rather than underneath the keel. With bed forms such as dunes the erosion increased, due to erosion at the dune tops and deposition in the troughs (10 passages of a conventional vessel over a dune resulted in a decrease in dune height of 20%). For the removal of small shoals this might be interesting, although a small underkeel clearance is necessary. Barges are preferred over conventional vessels due to the higher velocities and increased turbulence intensity. From the measured velocities during the physical model tests a model has been developed to predict the flow field underneath sailing inland navigation vessels. There are separate models for conventional vessels and for barges. The model is able to accurately predict maximum velocities (in sailing direction as well as in transverse direction), as well as a transverse velocity distribution. Compared to the previous prediction methods, the newly developed model is preferable. The results are more accurate, and the model is more extensive, due to the inclusion of transverse velocities and velocity distributions. More validation is required however, due to the lack of other data sets.Hydraulic EngineeringCivil Engineering and Geoscience
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