197,304 research outputs found
Occupation and bladder cancer in a hospital-based case-control study in Spain
No full textSamanic, C.M., Kogevinas, M., Silverman, D.T., Tardón, A., Serra, C., Malats, N., Real, F.X., Carrato, A., García-Closas, R., Sala, M., Lloreta, J., Rothman, N., Dosemeci, M
Disinfection by-products in drinking water and bladder cancer: evaluation of risk modification by common genetic polymorphisms in two case–control studies
Get PDFBeane Freeman LE, Kogevinas M, Cantor KP, Villanueva CM, Prokunina-Olsson L, Florez-Vargas O, Figueroa JD, Ward MH, Koutros S, Baris D, Garcia-Closas M, Schwenn M, Johnson A, Serra C, Tardon A, Garcia-Closas R, Carrato A, Malats N, Karagas MR, Rothman N, Silverman D
Dioxin revisited: developments since the 1997 IARC classification of dioxin as a human carcinogen
No full textIn 1997 the International Agency for Research on Cancer (IARC) classified 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; the most potent dioxin congener) as a group 1 carcinogen based on limited evidence in humans, sufficient evidence in experimental animals, and extensive mechanistic information indicating that TCDD acts through a mechanism involving the aryl hydrocarbon receptor (AhR), which is present in both humans and animals. The judgment of limited evidence in humans was based primarily on an elevation of all cancers combined in four industrial cohorts. The group 1 classification has been somewhat controversial and has been challenged in the literature in recent years. In this article we review the epidemiologic and mechanistic evidence that has emerged since 1997. New epidemiologic evidence consists primarily of positive exposure-response analyses in several of the industrial cohorts, as well as evidence of excesses of several specific cancers in the Seveso accident cohort. There are also new data regarding how the AhR functions in mediating the carcinogenic response to TCDD. The new evidence generally supports the 1997 IARC classification
Drinking Water Disinfection By-products, Genetic Polymorphisms, and Birth Outcomes in a European Mother-Child Cohort Study
No full textEU Sixth Framework Program for Research and Technological Development by the Research Directorate-Biotechnology, Agriculture and Food Research Unit [Food-CT-2006-036224]; NERC UK [NE/E008844/1]Kogevinas, M., Bustamante, M., Gracia-Lavedán, E., Ballester, F., Cordier, S., Costet, N., Espinosa, A., Grazuleviciene, R., Danileviciute, A., Ibarluzea, J., Karadanelli, M., Krasner, S., Patelarou, E., Stephanou, E., Tardón, A., Toledano, M.B., Wright, J., Villanueva, C.M., Nieuwenhuijsen, M
Total fluid and water consumption and the joint effect of exposure to disinfection by-products on risk of bladder cancer
No full textMichaud, D.S., Kogevinas, M., Cantor, K.P., Villanueva, C.M., Garcia-Closas, M., Rothman, N., Malats, N., Real, F.X., Serra, C., Garcia-Closas, R., Tardon, A., Carrato, A., Dosemeci, M., Silverman, D.T
Micronuclei assessment in the urothelial cells of women using hair dyes and its modulation by genetic polymorphisms
No full textEspinoza, F., Silverman, D., Kogevinas, M., Creus, A., Fernández, F., García-Closas, M., Tardon, A., García-Closas, R., Serra, C., Carrato, A., Rothman, N., Dosemeci, M., Malats, N., Marcos, R
Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes
No full textFigueroa, J.D., Malats, N., García-Closas, M., Real, F.X., Silverman, D., Kogevinas, M., Chanock, S., Welch, R., Dosemeci, M., Lan, Q., Tardón, A., Serra, C., Carrato, A., García-Closas, R., Castaño-Vinyals, G., Rothman, N
Urinary pH, cigarette smoking and bladder cancer risk
No full textAlguacil, J., Kogevinas, M., Silverman, D.T., Malats, N., Real, F.X., García-Closas, M., Tardón, A., Rivas, M., Torà, M., García-Closas, R., Serra, C., Carrato, A., Pfeiffer, R.M., Fortuny, J., Samanic, C., Rothman, N
Author Correction: Validating a breast cancer score in Spanish women. The MCC-Spain study (Scientific Reports, (2018), 8, 1, (3036), 10.1038/s41598-018-20832-0)
No full textDierssen-Sotos, T., Gómez-Acebo, I., Palazuelos, C., Fernández-Navarro, P., Altzibar, J.M., González-Donquiles, C., Ardanaz, E., Bustamante, M., Alonso-Molero, J., Vidal, C., Bayo-Calero, J., Tardón, A., Salas, D., Marcos-Gragera, R., Moreno, V., Rodriguez-Cundin, P., Castaño-Vinyals, G., Ederra, M., Vilorio-Marqués, L., Amiano, P., Pérez-Gómez, B., Aragonés, N., Kogevinas, M., Pollán, M., Llorca, J
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