11,266 research outputs found
Nien Chang
No full textNien Chang (January 28, 1915 – November 2, 2009) was a Chinese author who recounted her harrowing experiences of the Cultural Revolution in her memoir Life and Death in Shanghai.https://nsuworks.nova.edu/nsudigital_forums/1070/thumbnail.jp
Antiplatelet Effect of Marchantinquinone, Isolated from Reboulia Hemisphaerica, in Rabbit Washed Platelets
No full textPlatelet activation is involved in serious pathological situations, including atherosclerosis and restenosis. It is important to find efficient antiplatelet medicines to prevent fatal thrombous formation during the course of these diseases.Marchantinquinone, a natural compound isolated from Reboulia hemisphaerica, inhibited platelet aggregation and ATP release stimulated by thrombin (0.1 units mL(-1)), platelet-activating factor (PAF; 2 ng mL(-1)), collagen (10 mu g mL(-1)), arachidonic acid ( 100 mu M), or U46619 (1 mu M ) in rabbit washed platelets. The IC50 values of marchantinquinone on the inhibition of platelet aggregation induced by these five agonists were 62.0+/-9.0, 86.0+/-7.8, 13.6+/-4.7, 20.9+/-3.1 and 13.4+/-5.3 mu M, respectively. Marchantinquinone inhibited thromboxane B-2 (TxB(2)) formation induced by thrombin, PAF or collagen. However, marchantinquinone did not inhibit TxB(2) formation induced by arachidonic acid, indicating that marchantinquinone did not affect the activity of cyclooxygenase and thromboxane synthase. Marchantinquinone did inhibit the rising intracellular Ca2+ concentration stimulated by the five platelet- aggregation inducers. The formation of inositol monophosphate induced by thrombin was inhibited by marchantinquinone. Platelet cAMP and cGMP levels were unchanged by marchantinquinone.The results indicate that marchantinquinone exerts antiplatelet effects by inhibiting phosphoinositide turnover
Effects of Dicentrine, a Novel α1-Adrenoceptor Antagonist, on Human Hyperplastic Prostates
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Pharmacological Characteristics of Liriodenine, Isolated from Fissistigma Glaucescens,a Novel Muscarinic Receptor Antagonist in Guinea-Pigs
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KO-PLTs contain much less HMGB1 than GFP-PLTs.
No full textA, B: HMGB1 expression in the platelets of HMGB1-KO mice (KO-PLT); C, D: HMGB1 expression in the platelets of GFP mice (GFP-PLT); B, D: Enlarged images of the box areas in the image A and C. E: Semi-quantification of positively stained platelets with HMGB1 confirms the results of immunostaining showing that only a few (~7%) platelets in HMGB1-KO mice are positively stained with HMGB1 compared to more than 86.8% of platelets in GFP mice were positively stained with HMGB1. *P < 0.01 (GFP-PLT vs. KO-PLT). Green bars: 50 μm; Yellow bars: 10 μm.</p
A Conversation with Xianghong Feng, Author of Tourism and Prosperity in Miao Land
No full textIn this installment of Lexington Books\u27 Anthropology of Tourism: Heritage, Mobility and Society Author Conversations, series editor Michael A. Di Giovine talks to anthropologist Xianghong Feng, author of the book, Tourism and Prosperity in Miao Land: Power and Inequality in Rural China. With rich ethnographic detail, Feng focuses on the intersection of tourism development, power and inequality in the southern interior of China. Capital-intensive, elite-driven tourism has reshaped the social and cultural patterns of the ethnic Miao. Although tourism is often touted as able to empower women, lower classes, and minorities, Feng shows that often it reinforces the very power structures that it attempts to equalize
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