177,678 research outputs found
Identification of the Kna/Knb polymorphism and a method for Knops genotyping
No full textDNA mutations resulting in the McCoy and Swain-Langley polymorphisms have been identified on complement receptor 1 (CR1)-a ligand for rosetting of Plasmodium falciparum-infected RBCs. The molecular identification of the Kna/Knb polymorphism was sought to develop a genotyping method for use in the study of the Knops blood group and malaria
CR1 Knops blood group alleles are not associated with severe malaria in the Gambia
No full textThe Knops blood group antigen erythrocyte polymorphisms have been associated with reduced falciparum malaria-based in vitro rosette formation (putative malaria virulence factor). Having previously identified single-nucleotide polymorphisms (SNPs) in the human complement receptor 1 (CR1/CD35) gene underlying the Knops antithetical antigens Sl1/Sl2 and McC(a)/McC(b), we have now performed genotype comparisons to test associations between these two molecular variants and severe malaria in West African children living in the Gambia. While SNPs associated with Sl:2 and McC(b+) were equally distributed among malaria-infected children with severe malaria and control children not infected with malaria parasites, high allele frequencies for Sl 2 (0.800, 1,365/1,706) and McC(b) (0.385, 658/1706) were observed. Further, when compared to the Sl 1/McC(a) allele observed in all populations, the African Sl 2/McC(b) allele appears to have evolved as a result of positive selection (modified Nei-Gojobori test Ka-Ks/s.e.=1.77, P-valu
Uniqueness of the nonlinear elastic dielectric affine boundary value problem on the whole space and on cone-like regions
No full textConservation laws derived from the energy-momentum tensor are employed to establish under suitable sufficient conditions uniqueness in affine boundary value problems for the homogeneous nonlinear elastic dielectric on the whole space and on certain cone-like regions. In particular, the electric enthalpy is assumed to be strictly quasi-convex for the whole space, and strictly rank-one convex for cone-like regions. Asymptotic behaviour is also stipulated. Uniqueness results for corresponding affine boundary value problems of homogeneous nonlinear elastostatics are a special case of those derived here. © 2009 Springer-Verlag.</p
Bookreview R. Anthone, E. Janssens, S. Vervoort en J. Knops (red.), Peinzen. 49 filosofische vragen voor kinderen, Leuven: Acco, 2006
No full textR. Anthone, E. Janssens, S. Vervoort en J. Knops (red.), Peinzen. 49 filosofische vragen voor kinderen, Leuven: Acco, 200
Manifolds in a theory of microstructures
No full textA synopsis, broadly based on contributions by Capriz and co-workers, is presented of a model for a body with microstructure that employs the Cartesian product of a Euclidean space (a fit set part of which is instantaneously occupied by the gross image of the body) and a Riemannian manifold each of whose members specifies a microstructure. Motivation is provided by known special theories. Macro and micro kinetic energy, kinetic coenergy, and inertia are discussed preparatory to the derivation of the governing nonlinear partial differential equations from the Lagrangian action principle, Noether’a theorem, and a Hamiltonian formulation. Precise mathematical specification of initial and boundary conditions remains fragmentary.</p
Uniqueness and Complementary Energy in Nonlinear Elastostatics
No full textGlobal uniqueness of the smooth stress and deformation to within the usual rigid-body translation and rotation is established in the null traction boundary value problem of nonlinear homogeneous elasticity on a n-dimensional star-shaped region. A complementary energy is postulated to be a function of the Biot stress and to be para-convex and rank-(n-1) convex, conditions analogous to quasi-convexity and rank-(n-2) of the stored energy function. Uniqueness follows immediately from an identity involving the complementary energy and the Piola-Kirchhoff stress. The interrelationship is discussed between the two conditions imposed on the complementary energy, and between these conditions and those known for uniqueness in the linear elastic traction boundary value problem
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