1,720,975 research outputs found
3D Cell Printing of Perfusable and Vascularized Human Skin Equivalents Composed of Epidermis, Dermis, and Hypodermis for Better Recapitulation of Skin Anatomy
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Size-tunable Biofabrication of Metastatic Melanoma Units (MMUs) via In Situ 3D Cell Printing
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Development of perfusable vascularized human skin equivalent using 3D cell-printing technique for better recapitulation of complexity of skin anatomy
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3D cell printing of perfusable vascularized human skin models for better structural recapitulation
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3D in-bath triple coaxial cell-printing of geometry-tunable brain blood vessels for cancer extravasation study
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Development of Perfusable In vitro Human Skin Model Composed of Epidermis, Dermis, and Hypodermis Using 3D Cell Printing
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The effects of individual motivations and social capital on employees' tacit and explicit knowledge sharing intentions
No full textDue to the importance of knowledge in today's competitive world, an understanding of how to enhance employee knowledge sharing has become critical. This study develops an integrated model to understand key factors of employee knowledge sharing intentions through constructs prescribed by two established knowledge management research streams, namely, those concerning individual motivations and social capital. This study classifies employee knowledge sharing intentions as either tacit or explicit and investigates whether the level of the determinants and their influences differ between the two. The research model is tested with survey data collected from 2010 employees in multiple industries. Analysis results show that the proposed model significantly explains the variance of employees' tacit and explicit knowledge sharing intentions. This finding indicates that the model's unified perspective enhances our knowledge of how to improve employee knowledge sharing. The new findings reveal that organizational rewards have a negative effect on employees' tacit knowledge sharing intentions but a positive influence on their explicit knowledge sharing intentions. The analysis results confirm that reciprocity, enjoyment, and social capital contribute significantly to enhancing employees' tacit and explicit knowledge sharing intentions. Additionally, these factors have more positive effects on tacit than on explicit knowledge intentions. The implications of the new findings are discussed. (C) 2012 Elsevier Ltd. All rights reserved
Coaxial Cell-printing of Freestanding, Perfusable and Functional in vitro Vascular Models for Recapitulation of Native Vascular Endothelium Pathophysiology
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Postprandial sodium sensing by enteric neurons in Drosophila
No full textSodium is essential for all living organisms(1). Animals including insects and mammals detect sodium primarily through peripheral taste cells(2,3,4,5,6,7). It is not known, however, whether animals can detect this essential micronutrient independently of the taste system. Here, we report that Drosophila Ir76b mutants that were unable to detect sodium(2) became capable of responding to sodium following a period of salt deprivation. From a screen for cells required for the deprivation-induced sodium preference, we identified a population of anterior enteric neurons, which we named internal sodium-sensing (INSO) neurons, that are essential for directing a behavioural preference for sodium. Enteric INSO neurons innervate the gut epithelia mainly through their dendritic processes and send their axonal projections along the oesophagus to the brain and to the crop duct. Through calcium imaging and CaLexA experiments, we found that INSO neurons respond immediately and specifically to sodium ions. Notably, the sodium-evoked responses were observed only after a period of sodium deprivation. Taken together, we have identified a taste-independent sodium sensor that is essential for the maintenance of sodium homeostasis.
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