376 research outputs found
Alcohol consumption and hospitalization burden in an adult Italian population: prospective results from the Moli-sani study
No full textBackground and aims: Epidemiological evidence on the impact of different alcohol drinking patterns on health-care systems or hospitalizations is sparse. We investigated how the different average volumes of alcohol consumed relate to all-cause and cause-specific hospitalizations. Design: Prospective cohort study (baseline 2005–10) linked to a registry of hospital discharge records to identify hospitalizations at follow-up (December 2013). Setting: Molise region, Italy. Participants: A total of 20 682 individuals (48% men, age ≥ 35 years) who participated in the Moli-sani Study and were free from cardiovascular disease or cancer at baseline. Measurements: The alcohol volume consumed in the year before enrolment was classified as: life-time abstainers, former drinkers, occasional drinkers and current drinkers who drank 1–12 (referent), 12.1–24, 24.1–48 and > 48 g/day of alcohol. Cause-specific hospitalizations were assigned by Italian Diagnosis Related Groups classification or by ICD-9 code of main admission diagnoses. Incidence rate ratios (IRR) of hospitalization were estimated by Poisson regression, taking into account the total number of admissions that occurred during the follow-up per person. Findings: During a median follow-up of 6.3 years, 12 996 multiple hospital admissions occurred. In multivariable analyses, life-time abstainers and former drinkers had higher rates of all-cause [IRR = 1.11, 95% confidence interval (CI) = 1.05–1.17 and IRR = 1.19, 95% CI = 1.02–1.31, respectively] and vascular (IRR = 1.14, 95% CI = 1.02–1.27 and IRR = 1.48, 95% CI = 1.24–1.76, respectively) hospitalizations compared with light alcohol consumers. Alcohol consumption > 48 g/day was associated with a higher rate of hospitalization for both alcohol-related diseases (IRR = 1.74, 95% CI = 1.32–2.29) and cancer (IRR = 1.36, 95% CI = 1.12–1.65). The magnitude of the association between heavier alcohol intake and hospitalization tended to be greater in smokers than non-smokers. No associations were observed with hospitalization for trauma or neurodegenerative diseases. Conclusions: Moderate alcohol consumption appears to have a modest but complex impact on global hospitalization burden. Heavier drinkers have a higher rate of hospitalization for all causes, including alcohol-related diseases and cancer, a risk that appears to be further magnified by concurrent smoking
Recommended from our members
PREVALENCE AND SCREENING OF HIGH LIVER STIFFNESS AND ALCOHOL ASSOCIATED FATTY LIVER DISEASE: A NATIONALLY REPRESENTATIVE ANALYSIS AND STRATEGY
No full textChronic liver disease (CLD) is a major healthcare burden for the United States, responsible for 60,000 deaths annually and recently surpassing heart failure hospitalization rates. We analyzed 4,510 adults sampled by the National Health and Nutrition Examination Survey (NHANES) in the cycle of 2017-2018 who underwent non- invasive vibration-controlled transient elastography (VCTE). Participants are enrolled using a stratified multistage probability with an oversampling design that allows a weighted and simplified representation of the civilian US population.
In the first paper, we intended to examine the national estimated prevalence of increased liver stiffness (LSM) measured by VCTE among these participants to characterize the at-risk population. Once the proportion and phenotype were identified, we constructed a screening score based on the variables associated with increased liver stiffness and advanced cirrhosis. The score was validated by calculating C- statistics and compared to the recommended screening FIB-4 score.
VCTE data from the same cohort provided controlled attenuation parameter (CAP), which measures hepatic steatosis.
Alcohol-associated liver disease (ALD) is responsible for rising rates of cirrhosis and liver-related mortality in the US. It is also one of the most common causes of fatty liver disease (FLD), which is the major contributor of CLD. Considering the lack of evidence on the mechanism and the quantity of alcohol that contributes to fatty liver disease progression, we performed multiple regression models in the second paper using dietary recall to identify the associations between the multiple consumption dimensions and the type of alcohol consumed with hepatic steatosis
Alcohol consumption and self-reported sunburn: A cross-sectional, population-based survey
No full text
- …
