177 research outputs found
Applications, challenges, and opportunities of blockchain technology in banking and insurance/ S. L. Gupta, Pooja Kansra, and Gagan Kukreja, editors.
No full textIncludes bibliographical references and index."This book offers an overall image of the evolution of blockchain technology and its application concerning warehouse or storage management in the development of operation networks and presents critical problems and proposed initial solutions for the blockchain technology's application in the banking and Insurance sectors"--1 online resourc
Multicomponent targeted proapoptotic anticancer drug delivery system
No full textCancer is one of the leading causes of death in United States. The current approaches for the treatment of solid tumor available are the surgery for the removal of primary tumor followed by chemotherapy and /or radiation. The efficacy of chemotherapy is limited by the following factors; (1) adverse side-effects on healthy organs, (2) development of cellular resistance and (3) low solubility of many anticancer drugs. The primary objective of this dissertation is to overcome all the above stated limitations. The methods employed in this dissertation includes designing, synthesizing and evaluating a novel drug delivery system comprising of 1) multiple copies of an anticancer drug, Camptothecin (CPT) ; 2) a polymeric carrier, Polyethylene glycol (PEG); 3) multiple copies of a targeting moiety to cancer cells, Luteinizing hormone releasing hormone (LHRH) peptide; 4) multiple copies of a suppressor of antiapoptotic cellular defense, BH3 peptide both in vitro and in vivo on A2780 human ovarian carcinoma cells and malignant ascites and animal models respectively. Conjugates of CPT, LHRH and CPT, LHRH, BH3 were evaluated for cytotoxicity, cancer specificity and antitumor activity. The multicomponent anticancer delivery system will significantly enhance the efficacy of an anticancer drug in the treatment of all the stages of cancer when compared with free drug, non-targeted delivery systems or the system consisting of one copy of each active component.Ph.D.Includes bibliographical referencesIncludes vitaby Pooja Chandn
What does the rise of avatars mean for consumers? A Systematic literature review and future research opportunities
No full textAs avatars are increasingly becoming popular, both scholars and businesses are acknowledging the vast potential that avatars hold for the future. Despite this growing interest in avatars, no review articles have attempted to provide a comprehensive overview of avatar literature and its implications for consumers. The present review addresses this gap using the combination of descriptive analysis (for corpus performance), bibliometric analysis (for corpus performance and emerging themes), and thematic analysis (for emerging themes and implications as well as future research opportunities). We conducted a review of 47 Scopus-indexed articles from 34 journals between year 2006 and 2023. By examining the corpus performance of avatar literature, the emerging themes, and future research opportunities, this review offers scholars a comprehensive overview of the subject matter
Leveraging the Applications of Value Co-creation in Bleisure Travel: Insights from Select Case Studies and Pedagogical Approach
No full textWith regard to bleisure travel, a relatively emerging concept in tourism, referring to the phenomenon that business travellers extend their business trips by adding leisure activities, this chapter discusses the use of value co-creation in bleisure travel. The emphasis of value co-creation is on how it might be possible for the clients and service providers to enhance the traveller experience in its entirety. When people travel for work but seek a business trip leisure option, there is a growing desire for highly personal and specific solutions. In view of the dynamic new demands that are surfacing from the travellers, this chapter seeks to look at the ways in which the service providers can adopt value co-creation so as to provision services that reflect their business and or personal interest. This chapter focuses on the future of learning through case study and collaborative service design teaching methodology. Lastly, it employs the case of Marriott International and its ‘Travel Brilliantly’ campaign where use of correct procedures that can enhance traveller participation and customer loyalty has been described. Such insights stress the importance of engaging in value co-creation and adapting to the trends that comprise bleisure travel to provide outstanding, individualized travel experiences
Offshoring and outsourcing of core corporate activities: the global relocation of pharmaceutical industry clinical trials
No full textThis dissertation examines the offshoring and outsourcing of core activities in the pharmaceutical industry. Using primary and secondary data sources, the dissertation adopts a multi-level approach to examine four research questions related to the sourcing strategies of core activities such as clinical trials. Specifically, I look at operational and strategic factors that influence the decision to relocate core activities both organizationally (in-house versus external vendors) and geographically (activities conducted in home nation versus trials in foreign countries). Drawing on Dunning's framework, the dissertation next examines the role of four motives (resource, market, efficiency and strategic asset seeking) in the offshoring decisions while distinguishing between offshore outsourcing and offshoring to foreign affiliates. Using multiple case studies, the third study further investigates the evolution of firms sourcing strategies from conducting core activities in-house to increasingly outsourcing and offshoring them. The final study in the dissertation examines the impact of offshoring and outsourcing on the performance of core activities. Data for this dissertation comes from multiple sources: Primary data from in-depth structured interviews and online survey of vice presidents of clinical affairs of pharmaceutical and biotechnology firms, as well as secondary data from Medidata, Orbis, and World Development Indicators. The dissertation offers evidence that firms tend to use different sourcing strategies for different motives. Specifically, offshoring to foreign affiliates is primarily driven by strategic factors and firms tend to prefer this strategy for strategic asset seeking purposes. Offshore outsourcing on the other hand is motivated by resource and efficiency seeking behavior and the important determinants for this strategy are mainly operational. The third type of sourcing strategy is domestic outsourcing and firms are driven by both strategic as well as operational determinants for this strategy. The qualitative study on strategy evolution points towards a five stage process which begins with in-house sourcing followed by domestic outsourcing, foreign affiliates, offshore outsourcing and finally backsourcing of core activities. Evidence from the dissertation suggests that outsourcing has a positive impact on performance when compared to in-house while offshoring has a negative impact compared to domestic sourcing.Ph.D.Includes abstractVitaIncludes bibliographical referencesby Pooja Thaku
Hope, Nihilism, and Faith in the World of Professional Wrestling and Its Data- Driven Monetization
No full textA world filled with new technologies, global challenges, and evolving social values gives rise to the philosophical strands of humanity, hope, and nihilism. Disparate yet deeply related, these concepts allow us to address the paradoxes of human existence. Humanity denotes the common sentiments, values, and responsibilities that define us as social beings. It signifies compassion, collaboration, and advancement, which aids in forming moral and social structures. While hope, in contrast, fuels motivation and creativity, even in the bleakest of times. It is the confidence of better outcomes that drives people and nations. On the contrary nihilism, which denies existence or any meaning and purpose, illustrates the disenchantment that emerges in the absence of functioning systems, collapsing ideologies, or unresolved essential inquiries
Awareness of Causes, Consequences and Preventive Measures of Obesity among Adolescents in India
Get PDFBackground: The burden of obesity is rapidly increasing worldwide. Obesity is associated with wide range of diseases, including cardio respiratory disease such as chronic obstructive pulmonary disease and coronary heart disease. Aims: This study aimed to assess the awareness of the adolescents towards the causes, consequences and preventive measures of obesity. Methods: The present study was based on primary data. The study included 200 adolescents surveyed as per convenience sampling. The analysis was made with descriptive statistics and multivariate logistic regression. Results: The study identified that 64.0 percent of the respondents suffered from obesity at the time of survey. The logistic regression shows that obesity was associated with gender, age, education of the mother, income and eating habits of the breakfast. Thus, logistic regression clearly highlighted that obesity was associated with changing lifestyle. But, the awareness of the risk factors and the preventive measures of obesity was not clear among the adolescents. Conclusion: The present study provides sufficient evidence on the awareness of the causes, risk factors and preventive measures of obesity and calls for an immediate action to scale up cost-effective interventions for it both through private and public hospitals. Thus, study indicates a need for creating awareness among adolescents towards the consequences and preventive measures through mass media and campaigns at the schools
Target reliability indices for quay walls, jetties, and flexible dolphins
No full textStructural codes rely on generalised target reliability indices, which are mainly derived for buildings. It is unclear, however, whether these indices are applicable to the specific risk-profile of quay walls, jetties, and flexible dolphins. In this study, target reliability indices for marine structures were derived from various risk acceptance criteria, such as economic optimisation, individual risk, societal risk, the life quality index, and the social and environmental repercussion index. This article uses a method to determine reliability targets distinguishing time-dependent and time-independent variables, because some important stochastic design variables in the design of marine structures, such as soil and material properties, are largely time-independent. The assessment framework of ISO 2394, taking into account social, economic, and environmental impact, has proven to be a solid basis for reliability differentiation. The method of approach considered in this paper can also be used for evaluating target reliability indices of other geotechnical structures.Accepted Author ManuscriptHydraulic Structures and Flood Ris
Awareness about Diabetes Risk Factors and Prevention Strategies among Women of Punjab
Get PDFObjective: Diabetes is a huge challenge to country’s health and economy. It has been widely debated that in order to reduce the incidence and consequences of diabetes, its awareness among the masses is pre-requisite. Thereby, in the present paper an attempt has been made to examine the awareness of the risk factors and preventive strategies of diabetes among women. Materials and Methods: The study was based on primary data collected from 200 women from Jalandhar. The analysis of the data has been made with the help of frequencies, percentages and weighted average score. Results: It has been found that 96 percent of the women were aware of diabetes. However, only 42 percent, 30 percent, 22 percent, 13 percent and 29 percent were aware of prevention of diabetes, vaccine for diabetes, complete cure for diabetes and susceptibility of diabetes. Conclusion: These figures are compelling enough to stimulate government to decide to take corrective actions to address the awareness of diabetes among women. It was also found the awareness of the risk factors and preventive measures was low among the sampled respondents. Need of the hour is to create awareness of diabetes, risk factors and lifestyle changes which can prevent or delay diabetes
Dynamic Planning for Flexible Port Infrastructure after Panama Canal Expansion: A Real Case Study
No full textThis paper presents a study carried out to first assess the impact of the Panama Canal expansion (PCE) on selected Caribbean ports, and thereafter, to examine how the ports can adapt in order to seize new opportunities created by the expansion. An applied case of long-term dynamic planning and flexibility in engineering design is presented for a new port terminal in Barranquilla, Colombia. Furthermore, this paper presents the results of a stochastic method for quantifying opportunities from containerized traffic using dynamic forecasting, real options analysis, and Monte Carlo simulation, within the framework and spirit of adaptive port planning under uncertainty.Accepted Author ManuscriptRivers, Ports, Waterways and Dredging Engineerin
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