66 research outputs found
Abstract P1-08-02: Mutant GATA3 actively promotes the growth of normal and malignant mammary cells
No full textAbstract
GATA3 is a transcription factor expressed in luminal breast epithelial cells and is required for mammary gland development. Analysis of TCGA data reveals that somatic heterozygous mutations in GATA3 occur in up to 15% of estrogen receptor positive breast tumors, and that these tumors are diagnosed a median of eight years earlier than other estrogen receptor positive tumors, suggesting a more aggressive phenotype. These mutants have been proposed to be null alleles resulting in haploinsufficiency, however the mutation spectrum of GATA3 in breast cancer is in sharp contrast to that found in HDR syndrome, a true GATA3 haploinsufficiency disease. Based on this disparity, we propose that there is a selective pressure to mutate and retain a portion of the GATA3 in breast cancer. Here we focus on the GATA3 mutants which lack the second zinc finger which is responsible for GATA motif binding. Expression of these mutants accelerated xenograft tumor growth by ZR751 cells, and transgenic expression in mouse mammary glands promoted precocious lobuloalveolar development. We have used integrated gene expression and ChIP-Seq profiling to demonstrate that these zinc-finger deleted proteins retain the ability to associate with the genome by tethering to complexes associated with FOXA1 and AP-2gamma recognition motifs, where they modulate the expression of adjacent genes. These data support a model in which the GATA3 mutations recently observed in breast cancer encode for active transcription factors which elicit proliferative phenotypes in normal mammary epithelium and promote the growth of estrogen receptor positive breast cancer cell lines.
Citation Format: Kenny PA, Chandiramani N, Lofgren KA. Mutant GATA3 actively promotes the growth of normal and malignant mammary cells [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P1-08-02.</jats:p
Book review: To Chain the Dog of War: The War Power of Congress in History and Law. By Francis D. Wormuth and Edwin B. Firmage, with Francis P. Butler as a contributing author.
No full textBook review: To Chain the Dog of War: The War Power of Congress in History and Law. By Francis D. Wormuth and Edwin B. Firmage, with Francis P. Butler as a contributing author. Dallas, Tex.: Southern Methodist University
Press. 1986. Pp. xi, 347. Reviewed by: Charles A. Lofgren.Lofgren, Charles A.. (1988). Book review: To Chain the Dog of War: The War Power of Congress in History and Law. By Francis D. Wormuth and Edwin B. Firmage, with Francis P. Butler as a contributing author.. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/164965
A Structural Econometric Model of Consumer Demand at Pick-Your-Own Fruit Operations
No full textThis paper develops a fully structural econometric consumer demand model for goods which have time and monetary costs, and where time spent obtaining the goods also enters into the utility function. The model is used to analyze customers' decision to buy pick-your-own versus pre-harvested fruit at North Carolina pick-your-own fruit operations. The empirical application distinguishes the double effect of time as a resource constraint and also providing utility. Elasticity estimates show that strawberries sold at pick-your-own operations are price elastic, with pick-your-own fruit being less price elastic than pre-harvested fruit.Consumer/Household Economics,
Post-industrialism, the information society, and librarianship : a critique
No full textThis thesis was scanned from the print manuscript for digital preservation and is copyright the author.
Researchers can access this thesis by asking their local university, institution or public library to
make a request on their behalf. Monash staff and postgraduate students can use the link in the References field
The Bug Creek problem and the Cretaceous-Tertiary transition at McGuire Creek, Montana
No full textBug Creek assemblages from Montana, transitional in composition between typical Cretaceous and Paleocene vertebrate faunas, are critical to K-T extinction debates because they have been used to support both gradual and catastrophic K-T extinction scenarios. Geological and palynological data from McGuire Creek indicate that Bug Creek assemblages are Paleocene and restricted to channel fills entrenched into older sediments, suggesting that the Cretaceous component of the assemblage was reworked. Thus, the author concludes, "Paleocene dinosaurs" are an illusion and the K-T survival rate of mammals is low because the presence of Cretaceous mammals in Bug Creek assemblages is also the result of reworking
Balancing Liberty and Security: A Proposal for Amplified Procedural Due Process Protections in the U.S. Sanctions Regime
No full textThis Note will concentrate on procedural due process concerns stemming from the imposition of terrorist financing sanctions, and it will primarily discuss designated U.S. persons. This is a narrow focus, but it can be viewed as a microcosm for due process issues present throughout the broader IEEPA [International Emergency Economic Powers Act] regime. Ultimately, this Note will conclude that OFAC [Office of Foreign Assets Control]\u27s terrorist financing designation process inadequately protects the procedural due process rights of targets, and it will advocate for the implementation of additional procedural protections that balance undeniable constitutional requirements with the critical concern of national security.
This Note will be organized as follows: Part I will explore the broader background of sanctions, beginning with a short history of emergency powers in the United States, including the Trading with the Enemy Act (TWEA) and IEEPA. Additionally, it will outline the structure of the current U.S. sanctions regime and the process for implementing sanctions under IEEPA (with a particular focus on the role of OFAC in administering and enforcing sanctions). Lastly, Part I will explain the role of each of the three branches of the federal government in the sanctions framework and address a range of key concerns about IEEPA. Part II will (1) briefly discuss due process jurisprudence in the United States; (2) analyze key procedural due process cases in the sanctions realm, with a targeted focus on two issues: the use of classified information in the government’s designation decisions and the diminished right to notice and an opportunity to be heard; and (3) discuss the particularly severe impact of designation on individuals. Part III will begin with a discussion of recent criticisms of the U.S. sanctions process and will be followed by a detailed evaluation of the Department of the Treasury’s 2021 Sanctions Review. Finally, Part III will recommend amending both OFAC’s regulations and IEEPA to provide for more adequate procedural protections during the designation and deprivation process.
This abstract has been adapted from the author\u27s introduction
Disclosure and Fit Capability of the Filtering Facepiece Respirator
No full text The filtering facepiece air-purifying respirator is annually purchased in the tens of millions and widely used for worker protection from harmful airborne particulates. The workplace consumers of this safety product, i.e., employers, workers, and safety and health professionals, have assurances of its effectiveness through the respirator certification and disclosure requirements of the National Institute for Occupational Safety and Health. However, the certification of a critical performance requirement has been missing for the approved filtering facepiece respirator since 1995: fit capability. Without this certification, consumers continue to be at risk of purchasing a respirator model that may fit a small percentage of the intended users. This commentary updates and expands an earlier one by this author, addresses the consequences of poorly fitting certified models on the market and lack of disclosure, and calls for further action by National Institute for Occupational Safety and Health to meet the needs and expectations of the consumer. </jats:p
Recovery versus Reversion: The Implications of Multiple Signifieds in Ooka Shohei’s Fires on the Plain
No full textMuch of the scholarship on Ooka Shohei’s Fires on the Plain (Nobi, 1952; trans. 1957) is predicated on the assumption that the protagonist, Pfc. Tamura, is insane. This issue crystalizes when, at the end of the novel, Tamura returns to behavior he had previously rejected, now unconcerned about what people might think of him. The language Ooka uses is subject to slippage which, in turn, creates trace structures of related meaning that problematize this assumption of insanity. As a consequence, the reader is forced to consider what meaning the text might have with a sane narrator, and why the author may have chosen to claim insanity for his protagonist. The answers point to both the expectations of readers in the aftermath of Japan’s defeat in World War Two, and a strengthening of the cautionary message implicit in the novel
<Article>Recovery versus Reversion : The Implications of Multiple Signifieds in ?oka Sh?hei’s Fires on the Plain
No full textMuch of the scholarship on ?oka Sh?hei?s Fires on the Plain (Nobi 1952; trans. 1957) is predicated on the assumption that the protagonist Pfc. Tamura is insane. This issue crystalizes when at the end of the novel Tamura returns to behavior he had previously rejected now unconcerned about what people might think of him. The language ?oka uses is subject to slippage which in turn creates trace structures of related meaning that problematize this assumption of insanity. As a consequence the reader is forced to consider what meaning the text might have with a sane narrator and why the author may have chosen to claim insanity for his protagonist. The answers point to both the expectations of readers in the aftermath of Japan?s defeat in World War Two and a strengthening of the cautionary message implicit in the novel.departmental bulletin pape
<Article>Recovery versus Reversion : The Implications of Multiple Signifieds in ?oka Sh?hei’s Fires on the Plain
No full textMuch of the scholarship on ?oka Sh?hei?s Fires on the Plain (Nobi 1952; trans. 1957) is predicated on the assumption that the protagonist Pfc. Tamura is insane. This issue crystalizes when at the end of the novel Tamura returns to behavior he had previously rejected now unconcerned about what people might think of him. The language ?oka uses is subject to slippage which in turn creates trace structures of related meaning that problematize this assumption of insanity. As a consequence the reader is forced to consider what meaning the text might have with a sane narrator and why the author may have chosen to claim insanity for his protagonist. The answers point to both the expectations of readers in the aftermath of Japan?s defeat in World War Two and a strengthening of the cautionary message implicit in the novel
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