54 research outputs found
EDIFICE OF DEPENDABLE BCD ADDER IN QUANTUM DOT CELLULAR
No full textThe advancement of the CMOS virtual format lies in reducing the technique era, projected to quit inside the next few years due to CMOS essential physical limits. Among the rising technologies recently proposed as alternatives to the traditional CMOS, Quantum-dot mobile automata (QCA) is one of the maximum promising answers to format ultra-low-energy and definitely excessive tempo virtual circuits. Efficient QCA-based totally implementations have been confirmed for several binary and decimal mathematics circuits, however considerable enhancements are still feasible if the logic gates inherently to be had within the QCA era are nicely exploited. Conventional unique adders need lengthy remove and high strength intake to acquire correct outcomes. Efficient QCA-based totally absolutely implementations have been verified for several binary and decimal arithmetic circuits; however massive upgrades are nevertheless viable if the coolest judgment gates inherently available within the QCA era are smartly exploited. This short proposes a new method to design QCA-based totally BCD adders. Exploiting progressive common sense formulations and purpose designed QCA modules, computational speed substantially higher than current contrary numbers are accomplished without sacrificing either the occupied vicinity or the cells depend
Anticancer and Antiviral Properties of Cardiac Glycosides: A Review to Explore the Mechanism of Actions
No full textCardiac glycosides (CGs) have a long history of treating cardiac diseases. However, recent reports have suggested that CGs also possess anticancer and antiviral activities. The primary mechanism of action of these anticancer agents is by suppressing the Na+/k+-ATPase by decreasing the intracellular K+ and increasing the Na+ and Ca2+. Additionally, CGs were known to act as inhibitors of IL8 production, DNA topoisomerase I and II, anoikis prevention and suppression of several target genes responsible for the inhibition of cancer cell proliferation. Moreover, CGs were reported to be effective against several DNA and RNA viral species such as influenza, human cytomegalovirus, herpes simplex virus, coronavirus, tick-borne encephalitis (TBE) virus and Ebola virus. CGs were reported to suppress the HIV-1 gene expression, viral protein translation and alters viral pre-mRNA splicing to inhibit the viral replication. To date, four CGs (Anvirzel, UNBS1450, PBI05204 and digoxin) were in clinical trials for their anticancer activity. This review encapsulates the current knowledge about CGs as anticancer and antiviral drugs in isolation and in combination with some other drugs to enhance their efficiency. Further studies of this class of biomolecules are necessary to determine their possible inhibitory role in cancer and viral diseases
Semen Analysis in Type 2 Diabetes Mellitus Patients with Infertility: Semen Analysis in Type 2 Diabetes Mellitus Patients with Infertility
No full textBackground: According to World Health Organization (WHO), the condition of infertility is related with inability to get conceived even after regular unprotected active sexual intercourse for one year. Nowadays, the prevalence of infertility is increasing day by day. Among couples who are desperate for pregnancy, about to 15% have complaints related to infertility.
Aim: The present study is aimed to analyze and compare different semen parameters among diabetic infertile males and non-diabetic fertile males.
Methods: This cross-section study done at Dr.Patnam Mahender Reddy Institute of Medical Sciences, Chevella and included 100 diabetic infertile and 100 fertile males. Subjects are selected as per inclusion and exclusion criteria. After 2 to 7 days of sexual abstinence, the semen samples were obtained by masturbation. Semen samples were then observed for microscopic and macroscopic examination as per WHO instructions. Blood sample was collected from a cubital vein, and serum was obtained. The results obtained were entered in tabular form with relevant heading of each parameter. The obtained data is analyzed IBM SPSS Statistics version 20.
Results: It has been observed that there was a significant decrease of sperm concentration, sperm motility, sperm count, semen volume and sperm morphology in diabetic infertile group when compared to non-diabetic fertile group with significant increase in semen liquefaction time and appearance of abnormal sperms.
Conclusion: Levels of Liquefaction time, abnormal appearance, viscosity and abnormal morphology were found to increased and sperm motility, concentration, count were observed to be decreased in the study group on comparison control group
ChemInform Abstract: Metal‐Free Aminooxygenation of Alkynes: Efficient Synthesis of 3‐Aroylimidazo[1,2‐a]‐N‐heterocycles.
No full textLanatoside C Induces G2/M Cell Cycle Arrest and Suppresses Cancer Cell Growth by Attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR Signaling Pathways
No full textCardiac glycosides (CGs) are a diverse family of naturally derived compounds having a steroid and glycone moiety in their structures. CG molecules inhibit the α-subunit of ubiquitous transmembrane protein Na+/K+-ATPase and are clinically approved for the treatment of cardiovascular diseases. Recently, the CGs were found to exhibit selective cytotoxic effects against cancer cells, raising interest in their use as anti-cancer molecules. In this current study, we explored the underlying mechanism responsible for the anti-cancer activity of Lanatoside C against breast (MCF-7), lung (A549), and liver (HepG2) cancer cell lines. Using Real-time PCR, western blot, and immunofluorescence studies, we observed that (i) Lanatoside C inhibited cell proliferation and induced apoptosis in cell-specific and dose-dependent manner only in cancer cell lines; (ii) Lanatoside C exerts its anti-cancer activity by arresting the G2/M phase of cell cycle by blocking MAPK/Wnt/PAM signaling pathways; (iii) it induces apoptosis by inducing DNA damage and inhibiting PI3K/AKT/mTOR signaling pathways; and finally, (iv) molecular docking analysis shows significant evidence on the binding sites of Lanatoside C with various key signaling proteins ranging from cell survival to cell death. Our studies provide a novel molecular insight of anti-cancer activities of Lanatoside C in human cancer cells
A Simple Perioperative Technique to Avoid Limb Length Inequality in Patients Undergoing Cemented Hemireplacement Arthroplasty of Hip Joint
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