2,071 research outputs found
Consumption of Fish and Long-chain n-3 Polyunsaturated Fatty Acids Is Associated With Reduced Risk of Colorectal Cancer in a Large European Cohort
No full textRegional Governments of Andalucía, Asturias, Basque Country, Murcia (No. 6236) and Navarra, and the Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública and Instituto de Salud Carlos II (ISCIII RETIC) (RD06/0020) (Spain)Aglago, E.K., Huybrechts, I., Murphy, N., Casagrande, C., Nicolas, G., Pischon, T., Fedirko, V., Severi, G., Boutron-Ruault, M.-C., Fournier, A., Katzke, V., Kühn, T., Olsen, A., Tjønneland, A., Dahm, C.C., Overvad, K., Lasheras, C., Agudo, A., Sánchez, M.-J., Amiano, P., Huerta, J.M., Ardanaz, E., Perez-Cornago, A., Trichopoulou, A., Karakatsani, A., Martimianaki, G., Palli, D., Pala, V., Tumino, R., Naccarati, A., Panico, S., Bueno-de-Mesquita, B., May, A., Derksen, J.W.G., Hellstrand, S., Ohlsson, B., Wennberg, M., Van Guelpen, B., Skeie, G., Brustad, M., Weiderpass, E., Cross, A.J., Ward, H., Riboli, E., Norat, T., Chajes, V., Gunter, M.J
Fruit and vegetable intake and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
No full text14136, Cancer Research UK; C8221/A19170, Cancer Research UK; EPIC, Ecumenical Project for International Cooperation; 1000143, MRC, Medical Research Council; C570/A16491, Cancer Research UK; MR/M012190/1, MRC, Medical Research Council; MRC, Medical Research CouncilPerez-Cornago, A., Travis, R.C., Appleby, P.N., Tsilidis, K.K., Tjønneland, A., Olsen, A., Overvad, K., Katzke, V., Kühn, T., Trichopoulou, A., Peppa, E., Kritikou, M., Sieri, S., Palli, D., Sacerdote, C., Tumino, R., Bueno-de-Mesquita, H.B., Agudo, A., Larrañaga, N., Molina-Portillo, E., Ardanaz, E., Chirlaque, M.-D., Lasheras, C., Stattin, P., Wennberg, M., Drake, I., Malm, J., Schmidt, J.A., Khaw, K.-T., Gunter, M., Freisling, H., Huybrechts, I., Aune, D., Cross, A.J., Riboli, E., Key, T.J
Association between classes and subclasses of polyphenol intake and 5-year body weight changes in the epic-panacea study
No full textConsejo Nacional de Ciencia y Tecnología, Grant/Award Number: ID 693636; Instituto de Salud Carlos III, Grant/Award Numbers: CD20/00071, CPII20/00009, FI19/00185, PI18/00191Castañeda J., Gil-Lespinard M., Almanza-Aguilera E., Llaha F., Gómez J.-H., Bondonno N., Tjønneland A., Overvad K., Katzke V., Schulze M.B., Masala G., Agnoli C., Santucci de Magistris M., Tumino R., Sacerdote C., Skeie G., Brustad M., Lasheras C., Molina-Montes E., Chirlaque M.-D., Barricarte A., Sonestedt E., da Silva M., Johansson I., Hultdin J., May A.M., Forouhi N.G., Heath A.K., Freisling H., Weiderpass E., Scalbert A., Zamora-Ros R
Alcohol and lung cancer risk: a pooled analysis using International Lung Cancer Consortium studies
No full textFehringer, G., Brenner, D.R., Zhang, Z.-F., Lee, Y.-C.A., Matsuo, K., Ito, H., Lan, Q., Vineis, P., Johansson, M., Overvad, K., Riboli, E., Trichopoulou, A., Sacerdote, C., Stucker, I., Boffetta, P., Brennan, P., Christiani, D.C., Hong, Y.-C., Landi, M.T., Morgenstern, H., Schwartz, A.G., Wenzlaff, A.S., Rennert, G., McLaughlin, J.R., Harris, C.C., Olivo-Marston, S., Orlow, I., Park, B.J., Zauderer, M., Barros Dios, J.M., Ruano Raviña, A., Siemiatycki, J., Koushik, A., Lazarus, P., Fernández-Somoano, A., Tardon, A., Le Marchand, L., Brenner, H., Saum, K.-U., Duell, E.J., Andrew, A.S., Szeszenia-Dabrowska, N., Lissowska, J., Zaridze, D., Rudnai, P., Fabianova, E., Mates, D., Foretova, L., Janout, V., Bencko, V., Holcatova, I., Pesatori, A.C., Consonni, D., Olsson, A., Straif, K., Hung, R.J
Identifying and correcting epigenetics measurements for systematic sources of variation
No full textBackground: Methylation measures quantified by microarray techniques can be affected by systematic variation due to the technical processing of samples, which may compromise the accuracy of the measurement process and contribute to bias the estimate of the association under investigation. The quantification of the contribution of the systematic source of variation is challenging in datasets characterized by hundreds of thousands of features. In this study, we introduce a method previously developed for the analysis of metabolomics data to evaluate the performance of existing normalizing techniques to correct for unwanted variation. Illumina Infinium HumanMethylation450K was used to acquire methylation levels in over 421,000 CpG sites for 902 study participants of a case-control study on breast cancer nested within the EPIC cohort. The principal component partial R-square (PC-PR2) analysis was used to identify and quantify the variability attributable to potential systematic sources of variation. Three correcting techniques, namely ComBat, surrogate variables analysis (SVA) and a linear regression model to compute residuals were applied. The impact of each correcting method on the association between smoking status and DNA methylation levels was evaluated, and results were compared with findings from a large meta-analysis. Results: A sizeable proportion of systematic variability due to variables expressing 'batch' and 'sample position' within 'chip' was identified, with values of the partial R2 statistics equal to 9.5 and 11.4% of total variation, respectively. After application of ComBat or the residuals' methods, the contribution was 1.3 and 0.2%, respectively. The SVA technique resulted in a reduced variability due to 'batch' (1.3%) and 'sample position' (0.6%), and in a diminished variability attributable to 'chip' within a batch (0.9%). After ComBat or the residuals' corrections, a larger number of significant sites (k = 600 and k = 427, respectively) were associated to smoking status than the SVA correction (k = 96). Conclusions: The three correction methods removed systematic variation in DNA methylation data, as assessed by the PC-PR2, which lent itself as a useful tool to explore variability in large dimension data. SVA produced more conservative findings than ComBat in the association between smoking and DNA methylation
Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development
No full textLi, Y., Xiao, X., Bossé, Y., Gorlova, O., Gorlov, I., Han, Y., Byun, J., Leighl, N., Johansen, J.S., Barnett, M., Chen, C., Goodman, G., Cox, A., Taylor, F., Woll, P., Erich Wichmann, H., Manz, J., Muley, T., Risch, A., Rosenberger, A., Han, J., Siminovitch, K., Arnold, S.M., Haura, E.B., Bolca, C., Holcatova, I., Janout, V., Kontic, M., Lissowska, J., Mukeria, A., Ognjanovic, S., Orlowski, T.M., Scelo, G., Swiatkowska, B., Zaridze, D., Bakke, P., Skaug, V., Zienolddiny, S., Duell, E.J., Butler, L.M., Houlston, R., Artigas, M.S., Grankvist, K., Johansson, M., Shepherd, F.A., Marcus, M.W., Brunnström, H., Manjer, J., Melander, O., Muller, D.C., Overvad, K., Trichopoulou, A., Tumino, R., Liu, G., Bojesen, S.E., Wu, X., Le Marchand, L., Albanes, D., Bickeböller, H., Aldrich, M.C., Bush, W.S., Tardon, A., Rennert, G., Dawn Teare, M., Field, J.K., Kiemeney, L.A., Lazarus, P., Haugen, A., Lam, S., Schabath, M.B., Andrew, A.S., Bertazzi, P.A., Pesatori, A.C., Christiani, D.C., Caporaso, N., Johansson, M., McKay, J.D., Brennan, P., Hung, R.J., Amos, C.I
Socioeconomic position and lifestyle in relation to breast cancer incidence among postmenopausal women: A prospective cohort study, Denmark, 1993-2006
No full textBackground: In Denmark, the incidence of breast cancer is higher among women with higher socioeconomic position. We investigated whether differences in exposure to certain risk factors contribute to this gradient, as measured from education, income and occupation. Methods: We conducted a cohort study of 23 111 postmenopausal women aged 50-65 years who were enrolled in the prospective Danish 'Diet, Cancer and Health' study between 1993 and 1995. At baseline, all women filled in a questionnaire on lifestyle and food frequency. The results were analysed in Cox proportional hazard models. Results: Part of the association with socioeconomic position is due to the potential mediators reproductive pattern, use of hormone replacement therapy and alcohol consumption. After simultaneous adjustment for these factors, the hazard ratios were 1.06 (95% confidence interval [CI], 0.88-1.27) for women with higher education and 1.07 (95% CI 0.85-1.34) for women with higher income. The HR ratio for women working as higher officials when compared with unskilled workers was 1.23 (0.96-1.59). Conclusion: The results support the hypothesis that the higher incidence of breast cancer among socially advantaged women is mediated partly by differences in exposure to reproductive factors, hormone replacement therapy and alcohol.Signe Benzon Larsen, Anja Olsen, John Lynch, Jane Christensen, Kim Overvad, Anne Tjønneland, Christoffer Johansen, Susanne Oksbjerg Dalto
Positive predictive value of first-time rheumatoid arthritis diagnoses and their serological subtypes in the Danish National Patient Registry
No full textAsta Linauskas,1,2 Kim Overvad,3 Martin Berg Johansen,4 Kristian Stengaard-Pedersen,1,5 Annette de Thurah1,5 1Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark; 2Department of Rheumatology, North Denmark Regional Hospital, Hjoerring, Denmark; 3Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark; 4Unit of Clinical Biostatistics, Aalborg University Hospital, Aalborg, Denmark; 5Department of Clinical Medicine, Aarhus University, Aarhus, Denmark Purposes: To assess whether the positive predictive value (PPV) of first-time rheumatoid arthritis (RA) diagnosis registration in the Danish National Patient Registry increases when data are linked to the RA treatment codes and to assess the PPV of first-time RA diagnoses according to RA serological subtypes.Methods: Participants from the Danish Diet, Cancer, and Health cohort with at least one RA diagnosis, registered at one of the Central Denmark Region hospitals in the Danish National Patient Registry during the period 1977–2016, were identified. Register-based RA diagnoses were verified by scrutinizing medical records against RA classification criteria or clinical case RA. PPVs for overall RA, seropositive RA, and other RA were calculated for two models: first-time RA diagnosis registration ever in the Danish National Patient Registry and first-time RA diagnosis registration ever where subsequently a prescription had been redeemed for a synthetic disease-modifying antirheumatic drug.Results: Overall, 205 of 311 first-time register-based RA diagnoses were verified (PPV: 61.9%; 95% CI: 56.9–67.0). Regarding RA serological subtypes, 93 of 150 register-based seropositive RA (PPV: 62.0; 95% CI: 53.9–69.5) and 36 of 144 other RA (PPV: 25.0; 95% CI: 18.5–32.8) were confirmed. When register-based RA diagnosis codes were linked to RA treatment codes, the PPVs increased substantially: the PPV for overall RA was 87.7% (95% CI: 82.5–91.5), the PPV for seropositive RA was 80.2% (95% CI: 71.6–86.7), and the PPV for other RA was 41.1% (95% CI: 30.2–52.9).Conclusion: The first-time RA diagnoses in the Danish National Patient Registry should be used with caution in epidemiology research. However, linking registry-based RA diagnoses to the subsequent RA treatment codes increases the probability of identifying true RA diagnoses, especially overall RA and seropositive RA. Keywords: administrative database research, Danish National Prescription Registry, Anatomical Therapeutic Chemical codes, seropositive rheumatoid arthritis, Denmar
Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts
No full textHealth Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology - ICO (Spain) (...)Karavasiloglou N., Hughes D.J., Murphy N., Schomburg L., Sun Q., Seher V., Rohrmann S., Weiderpass E., Tjønneland A., Olsen A., Overvad K., Boutron-Ruault M.-C., Mancini F.R., Mahamat-Saleh Y., Kaaks R., Kuhn T., Schulze M.B., Tumino R., Panico S., Masala G., Pala V., Sacerdote C., Derksen J.W.G., Skeie G., Hjartåker A., Lasheras C., Agudo A., Sánchez M.-J., Chirlaque M.-D., Ardanaz E., Amiano P., Van Guelpen B., Gylling B., Bradbury K.E., Papier K., Freisling H., Aglago E.K., Cross A.J., Riboli E., Aune D., Gunter M.J., Jenab M
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