107 research outputs found
PCN249 - Subjective Financial Burden Among German Cancer Patients - Relationship Of The Patients’ Economic Situation And Subjective Distress
No full textWitte J, Mehlis K, Kudlich M, et al. PCN249 - Subjective Financial Burden Among German Cancer Patients - Relationship Of The Patients’ Economic Situation And Subjective Distress. In: Value in Health. Vol 20. Elsevier Science; 2017: A457
To eat or not to eat: egg-based assessment of paternity triggers fine-tuned decisions about filial cannibalism
No full textMehlis M, Bakker TCM, Engqvist L, Frommen JG. To eat or not to eat: egg-based assessment of paternity triggers fine-tuned decisions about filial cannibalism. Proceedings of the Royal Society B. 2010;277(1694):2627-2635.Filial cannibalism occurs in many animal species ranging from insects to mammals, and is especially well described in teleost fishes. Numerous causes may lead to this behaviour, e. g. certainty of paternity. However, the cues males use to assess their paternity often remain unknown. One possible way to differentiate between own and foreign offspring is by using egg cues. Nevertheless, in egg-laying species, evidence for this is still scarce. In this study, male three-spined sticklebacks (Gasterosteus aculeatus), a fish with paternal care in which sneaking as well as filial cannibalism is common, were allowed to care for manipulated nests that contained different percentages of own fertilized eggs. After 7 days, embryo survival was determined. Furthermore, brood-caring as well as aggressive behaviour was measured daily. Clutches containing a higher proportion of foreign eggs were more likely to be completely cannibalized than clutches containing a lower proportion of foreign eggs, particularly when the clutch was laid early in the breeding season. However, the behavioural observations revealed no influence of paternity. The results show that paternity triggers filial cannibalism in sticklebacks and that males are able to evaluate their paternity using egg cues alone
Financial toxicity in German cancer patients: How does a chronic disease impact the economic situation?
No full textWinkler EC, Mehlis K, Surmann B, et al. Financial toxicity in German cancer patients: How does a chronic disease impact the economic situation? ANNALS OF ONCOLOGY. 2018;29(Suppl. 8):568
Medical Expenses Financial Burden on Cancer Patients - Evidence for the German Healthcare Context
No full textWitte J, Surmann B, Batram M, Mehlis K, Winkler E, Greiner W. Krankheitskosten – Finanzielle Belastung von Krebspatienten – Evidenz für den deutschen Versorgungskontext. Gesundheitsökonomie & Qualitätsmanagement . 2019;24(4):170-174
Financial toxicity in patients with colorectal cancer and neuroendocrine tumors.
No full textApostolidis L, Mehlis K, Witte J, et al. Financial toxicity in patients with colorectal cancer and neuroendocrine tumors. Journal of Clinical Oncology. 2018;36(15_suppl):6533-6533
Financial implications of cancer. Empirical data and ethical aspects
No full textMehlis K, Witte J, Surmann B, et al. Financial implications of cancer. Empirical data and ethical aspects. In: Manz MG, ed. Abstractband für die Virtuelle Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, 09.–11. Oktober 2020: Abstracts. Oncology Research and Treatment . Vol 43. Basel: Karger; 2020: 21-22
Patient-Reported Financial Distress in Cancer: A Systematic Review of Risk Factors in Universal Healthcare Systems
No full textPauge S, Surmann B, Mehlis K, et al. Patient-Reported Financial Distress in Cancer: A Systematic Review of Risk Factors in Universal Healthcare Systems. Cancers. 2021;13(19): 5015.Financial toxicity is a side effect of cancer that results from the perceived financial distress an individual may experience in the course of the disease. The purpose of this paper is to analyse underlying factors related to subjective financial distress in high-income countries with universal healthcare coverage. A systematic literature review was conducted to identify qualitative and quantitative studies of cancer patient-reported subjective financial distress by performing a search in the databases of PubMed, PsycINFO and CINAHL up to December 2020. A qualitative synthesis was performed linking the time-dependent occurrence of risk factors to derived categories of risk factors. Out of 4321 identified records, 30 quantitative and 16 qualitative studies were eligible. Classification of risk factors resulted in eight categories with a total of 34 subcategories. Subjective financial distress is primarily determined by pre-diagnosis sociodemographic- factors as well as financial and work factors that might change during the course of the disease. The design of healthcare and social security systems shapes the country-specific degree of subjective financial distress. Further research should focus on evolving multidisciplinary intervention schemes and multidimensional instruments for subjective financial distress to account for identified risk factors in universal healthcare systems more precisely
Inbreeding in three-spined sticklebacks (Gasterosteus aculeatus L.): effects on testis and sperm traits
No full textMating between relatives often results in inbreeding depression, and is assumed to have a strong effect on fitness traits such as fertility and gonad/gamete quality. However, data concerning this topic are contradictory and particularly scarce in fishes. Three-spined sticklebacks (Gasterosteus aculeatus L.) show inbreeding depression in fertilization and hatching success, survival rates, body symmetry and behavioural traits. To date, any knowledge of the impact of inbreeding on males ’ gonads and gametes is lacking in this species. In the present study, testis and sperm traits were quantified in outbred and inbred males. Overall, these traits were not generally impaired by inbreeding, and this result was not changed by a second/third generation of brother–sister matings. However, testes brightness, a potential measure of oxidative stress, was negatively correlated with sperm number. Addi-tionally, inbred males with higher body condition had significantly brighter testes, whereas their sperm number was significantly negatively correlated with sperm quality (as estimated by head volume). Such a trade-off did not appear in outbred males. The comparatively small impact of inbreeding on testis and sperm traits might be explained by the low number of inbred individuals that reached the reproductive phase. © 2012 The Linnean Society of London, Biological Journal of the Linnean Society, 2012, , ••–••. ADDITIONAL KEYWORDS: fish – heterozygosity – reproduction – sexual selection – sperm competition – testicular melanization
Methods for measuring financial toxicity after cancer diagnosis and treatment: a systematic review and its implications.
No full textWitte J, Mehlis K, Surmann B, et al. Methods for measuring financial toxicity after cancer diagnosis and treatment: a systematic review and its implications. Annals of oncology : official journal of the European Society for Medical Oncology. 2019;30(7):1061-1070.BACKGROUND: Patients experiencing financial distress as a side effect of cancer are not only reported in the US, but also in third-party payer healthcare systems in Europe. Since validated survey instruments are a prerequisite for robust and comparable results, we aimed to compile and classify available instruments to enable both a better understanding of the underlying construct of financial toxicity and to facilitate further studies that are adjustable to various healthcare systems.; MATERIALS AND METHODS: We did a systematic literature search on studies that provide data on perceived cancer-related financial distress experienced by adult patients using PubMed, CINAHL and Web of Science databases up to 2018. We analyzed all detected instruments, items domains and questions with regard to their wording, scales and the domains of financial distress covered.; RESULTS: Among 3,298 records screened, 41 publications based on 40 studies matched our inclusion criteria. Based on the analysis of 352 different questions we identified six relevant subdomains that represent perceptions of and reactions to experienced financial distress: (1) active financial spending, (2) use of passive financial resources, (3) psychosocial responses, (4) support seeking, (5) coping with care or (6) coping with ones' lifestyle. We found an inconsistent coverage and use of these domains that makes it difficult to compare and quantify the prevalence of financial distress. Moreover, some existing instruments do not reflect relevant domains for patients in third-party payer systems.; CONCLUSIONS: There is neither a consistent understanding of the construct of financial burden nor do available instruments cover all relevant aspects of a patients' distress perception. We encourage using the identified six domains to further develop survey instruments and adjust them to different health systems. © The Author 2019. Published by Oxford University Press on behalf of the European Society for Medical Oncology
Hieracium lachenalii var. pseudoperscissum Zahn 1934
No full text<i>Hieracium lachenalii</i> var. <i>pseudoperscissum</i> Zahn (1934: 540). <p>Ind. loc.: “ Thüringen: Wald am Ruppberg bei Zella → Mehlis (Bornmüller)!”</p> <p> <b>Lectotype (designated here by Gottschlich):</b> — GERMANY. Thuringia: a: Thür. Wald, Zella-Mehlis, Ruppberg, Laubwald, 650 m, 20 July 1928, <i>J. Bornmüller</i>; b: Thür. Wald: Zella-Mehlis, Ruppberg, bei der Oberf i rsterei, 20 July 1928, <i>J. Bornmüller</i> (B barcode B 10 0460357!; isolectotype: GERMANY. Thuringia: Thür. Wald: Zella-Mehlis, am Ruppberg, ca. 6–700 m, 20 July 1928, <i>J. Bornmüller</i> (B barcode B 10 0460358!).—Current name: <i>Hieracium lachenalii</i> subsp. <i>lachenalii</i>.</p> <p> <b>Remarks:</b> —The lectotype bears two labels (a+b). On label “a” Zahn noted the determination. Label “b” seems to be a handwritten copy by Bornmüller. Author and type of <i>Hieracium lachenalii</i> have changed, therefore the current name is <i>H. lachenalii</i> Suter (1802: 145) (subsp. <i>lachenalii</i>). The characters of the variety fall into the phenotypic variation of the type.</p>Published as part of <i>Vogt, Robert & Gottschlich, Günter, 2023, Type material in the Hieracium (Compositae: Cichorieae) collection of Joseph Bornmüller, pp. 81-126 in Phytotaxa 613 (2)</i> on page 96, DOI: 10.11646/phytotaxa.613.2.1, <a href="http://zenodo.org/record/8345535">http://zenodo.org/record/8345535</a>
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