229 research outputs found
A cage-based training, cognitive testing and enrichment system optimized for rhesus macaques in neuroscience research
No full textIn neurophysiological studies with awake non-human primates (NHP), it is typically necessary to train the animals over a prolonged period of time on a behavioral paradigm before the actual data collection takes place. Rhesus monkeys (Macaca mulatta) are the most widely used primate animal models in system neuroscience. Inspired by existing joystick- or touch-screen-based systems designed for a variety of monkey species, we built and successfully employed a stand-alone cage-based training and testing system for rhesus monkeys (eXperimental Behavioral Intrument, XBI). The XBI is mobile and easy to handle by both experts and non-experts; animals can work with only minimal physical restraints, yet the ergonomic design successfully encourages stereotypical postures with a consistent positioning of the head relative to the screen. The XBI allows computer-controlled training of the monkeys with a large variety of behavioral tasks and reward protocols typically used in systems and cognitive neuroscience research
Knowledge Management. Concepts and Best Practices
No full textLarry Prusak (Executive Director IBM Institute for Knowledge-Based Organizations ): Knowledge Management, both as a practice and as a discipline, is entering i t's second decade, happily, without all the false expectations of any beginning movement, but with a growing and solid base of practice and theory on which to b uild. The volume that follows is a particularly fine example of how solid resear ch , good thinking, and a narrative approach can produce a very substantial argu ment for the continuing saga of KM. This second edition presents recent sur vey results from the EFQM and OECD as well as an overview of the results form th e First Global Delphi Study on The Future of Knowledge Management by the Fraun hofer Competence Center Knowledge Management and the Humboldt University Berlin. The book shows how the integration of knowledge management activities into th e daily business tasks is carried out, and how pro-active change management work s, which are the latest advancements in measuring intellectual capital and how t o assess the current state of knowledge management. The Best and Good Practice examples in Knowledge Management are completed with a recent study by the Benchm arking Center TECTEM at the University St. Gallen (Switzerland). Best practice s in knowledge management from leading companies like Aventis, Arthur D. Little, British Aerospace plc., Hewlett-Packard, IBM, Phonak, Roche and Siemens are des cribed for practitioners in different industries. More than 100 KM-Tools are lis ted and classified according to the main application area. The book concludes wi th an overview on research funded by the European Commission in order to make K M Made in Europe a reality
How German Companies Employ Knowledge Management. An OECD Survey on Usage, Motivations and Effects
No full textBispidines for Dual Imaging
No full textThe efficient transformation of the hexadentate bispidinol 1 into carbamate derivatives yields functional bispidines enabling convenient functionalization for targeted imaging. The BODIPY- substituted bispidine 3 combines a coordination site for metal ions, such as radioactive 64CuII, with a fluorescent unit. Product 3 was thoroughly characterized by standard analytical methods, single crystal X-ray diffraction, radiolabeling, and photophysical analysis. The luminescence of ligand 3 was found to be strongly dependent on metal ion coordination: CuII quenches the BODIPY fluorescence, whereas NiII and ZnII ions do not affect it. It follows that, in imaging applications with the positron emitter 64CuII, residues of its origin from enriched 64Ni and the decay products
64NiII and 64ZnII, efficiently restore the fluorescence of the ligand. This allows for monitoring of the emitted radiation as well as the fluorescence signal. The stability of the 64CuII3 complex is investigated by transmetalation experiments with ZnII and NiII, using fluorescence and radioactivity detection, and the results confirm the high stability of 64CuII3. In addition, metal complexes of ligand 3 with the lanthanide ions TbIII, EuIII, and NdIII are shown to exhibit emission of the BODIPY ligand and the lanthanide ion, thus enabling dual emission detection
Knowledge Management. Best Practices in Europe
No full textOne out of two companies have increased their productivity or aved costs with knowledge management. This is a result from a comprehensive cross-industry survey in Europe about knowledge management run by the Competence Center Knowledge Management at Fraunhofer IPK, Germany. Best practices in knowledge management from leading companies like Arthur D. Little, Booz Allen & Hamilton, Celemi, Hewlett-Packard, IBM, Phonak, Roche, Skandia and Thomas Miller are described for practitioners in different industries. The book shows how to integrate knowledge management activities into the daily business tasks and processes, how to motivate people and which capabilities and skills are required for knowledge management. An overview of approaches on intellectual capital and more than 50 km tools are listed and classified. The book concludes with an overview of the leading knowledge management projects in serveral European countries
How German Companies Employ Knowledge Management. An OECD Survey on Usage, Motivations and Effects
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