1,365 research outputs found
Monetary and Fiscal Policies in Bulgaria: Lessons from the Historical Record
No full textThere are two aspects through which an economic policy can influence the economic situation – monetary and fiscal. Monetary and fiscal policies have different and sometimes controversial goals to achieve by means of specific instruments. While the mission of central banks is generally price stability, governments usually set their goals in the realm of economic growth and employment. Fiscal institutions , however, often use inflation in order to derive revenues (seigniorage) and finance budget deficits. Hence, inflation is viewed as a public finance phenomenon (Barro, 1979; Mankiw, 1987; Grilli, 1989). The purpose of this paper is to present a historical perspective on the behaviour of the monetary and fiscal policies pursued in Bulgaria from 1879, when the Bulgarian National Bank was established (soon after the liberation from the Ottoman Empire). Furthermore, historical time series of monetary and fiscal indicators give us the chance to study the link between government budget problems, fluctuations of monetary variables and inflation dynamics in different monetary episodes.monetary and fiscal policy, inflation, exchange rate
Financial stability, monetary autonomy and fiscal interference: Bulgaria in search of its way, 1879-1913
No full textThe Bulgarian monetary system was established, immediately after independence. Having experienced it already under Ottoman rule, newly independent Bulgaria adopted the bimetallic standard. Without being a member of the Latin Monetary Union, it tried broadly to follow the principles of the convention, yet with some exceptions, the most important of which concerned the limit on silver coinage. The absence of such a clause in Bulgaria turned out to be crucial since the financial needs of the recently established state triggered excessive silver coinage which resulted in a persistent agio - a positive and variable difference between the legal and the commercial value of silver coins.http://deepblue.lib.umich.edu/bitstream/2027.42/133079/1/wp979.pd
Monetary Policy in Southeast Europe on the Road to the Gold Standard
No full textSince the establishment of the international gold standard at the end of the 19th century, the possibility of attaining monetary stability in peripheral countries has been increasingly associated with the decision to peg the currency to an external reference. By contrast, the monetary system adopted in Europe over the previous five centuries had assured stability through the articulation between an internal currency for domestic exchanges and an external currency for foreign trade. The object of this research is to study the coexistence of different standards in the early monetary history of modern Bulgaria as a peculiar way of passing from the dual currency system of pre-modern Europe to a uniform, national and international, all-purpose currency in the form of the gold standard. The broader goal is to enquire, in historical and comparative perspective, how different monetary regimes affect the degrees of freedom of monetary policy
The establishment of the gold standard in Southeast Europe: convergence to a new system or divergence from an old one
No full textThe establishment of the Bulgarian monetary system, as that of other newborn Southeast European states, occurred at a time in which the very meaning of money was being redefined at an international level, with the establishment of the gold standard. The homologation of the Balkan “periphery” to the West European “center” occurred thus at a time in which the relations between center and periphery were undergoing a radical change. In fact, the relations between different economic spaces, between center and periphery, between domestic and foreign trade, depend crucially on the peculiar form taken by the monetary regime: different monetary regimes design different relations between internal and external money, and hence between domestic economy and foreign trade.
Should the diffusion of the gold standard be read univocally as the establishment of an age of gold out of an age of darkness? Or is it better understood as the transition from a secular age of gold and silver to a precarious age of gold? The purpose of this paper is to reinterpret this story in the light of the system that preceded it, namely the bimetallic system that had characterized European economies over the previous five centuries. In a historical and comparative perspective, the monetary history of Bulgaria, as that of other neighboring countries, appears not as a necessary, however troubled, convergence towards the ultimate and universal gold standard, but rather as an undecided, and therefore troubled, option between two historically alternative monetary standards, bimetallic and monometallic, each with its own advantages and drawbacks
Nurse\u27s role and activities at treating person with narcissistic personality disorder
No full textUvod: Narcisistična osebnostna motnja je kompleksna osebnostna motnja, ki zahteva, da se zdravstvena obravnava prilagodi značilnostim posameznika. Motnjo je težko zdraviti, saj je kronična. Temelj zdravljenja je v individualni psihoterapiji. Vloga medicinske sestre je, da osebo v procesu zdravljenja vodi, ji nudi podporo in pomoč. Medicinska sestra si mora postaviti tudi cilje, ki ji bodo pomagali pri delu s to osebo. Namen: Namen je celostno obravnavati narcisistično osebnostno motnjo in opredeliti vlogo medicinske sestre in aktivnosti zdravstvene nege v procesu zdravljenja osebe z narcisistično osebnostno motnjo. Metode dela: V diplomskem delu je uporabljena deskriptivna metoda dela s sistematičnim pregledom slovenske in tuje znanstvene in strokovne literature. Pri iskanju je upoštevan časovni okvir od leta 2011 do 2022. Uporabljenih je bilo skupno 38 enot literature, ki so bile iskane s pomočjo podatkovnih baz CINAHL, MedLine, Google Scholar, prek spletnega portala digitalne knjižnice Univerze v Ljubljani DiKul in iskalniku PubMed. Zaradi relevantnih podatkov, kot je vloga medicinske sestre pri osebi z narcisistično motnjo, so bili izjemoma vključeni tudi starejši članki, ki so bili odkriti že leta nazaj. Rezultati: Naloga medicinske sestre ni pozdraviti narcisistično osebnostno motnjo, temveč spodbuditi osebo k sodelovanju pri zdravljenju. Pri obravnavi osebe z narcisistično osebnostno motnjo se osredotoči na zdravljenje motnje oziroma izboljšanje njenega stanja. Razprava in zaključek: Vloga medicinske sestre ni, da bi spremenila vedenje osebe, vendar pa lahko globlje razumevanje te motnje ter ustrezen pristop in terapevtska komunikacija pripomorejo k uspešnejši obravnavi in izidu zdravljenja te motnje. Aktivnosti, ki jih medicinska sestra izvaja pri osebi z narcisistično osebnostno motnjo, so se izkazale za koristne.Introduction: Narcissistic personality disorder is a complex personality disorder that requires medical treatment to be tailored to the individual\u27s characteristics. The disorder is difficult to treat as it is chronic. The foundation of treatment is found in individual psychotherapy. Nurse is here to guide the person in the treatment process, provide support and assistance. The nurse\u27s role is to guide, support and help the person in the treatment process. The nurse must also set goals that will help her work with person who has narcissistic personality disorder. Purpose: The main purpose of this thesis is to comprehensively present the field of narcissistic personality disorder and to define the role of nurse and nursing activities in process of treating a person with narcissistic personality disorder. We want to determine the most important activities that a nurse performs in the process of treating narcissistic personality disorder. Methods: In this thesis a descriptive research method is used with a systematic overeview of Slovenian and foreign scientific and academic literature. Time of article\u27s edition was determined from 2011 to 2022. There were used 38 units of literature with help of searching databases CINAHL, MedLine, Google Scholar, through web portal of digital library of University in Ljubljana DiKul and PubMed. We took into consideration to not use articles older than from 2011 year, with exception to some of them to provide for relevance of the data, such as role of the nurse in treatment process of a person with narcissistic personality disorder, which were discovered years ago. Results: The nurse\u27s role is not to cure narcissistic personality disorder but to encourage the person to participate in the process of treatment. When treating a person with narcissistic personality disorder, the focus is on treatment and on improving it\u27s condition. Discussion and conclusion: The nurse\u27s role is not to change the person\u27s behavior, but a deeper understanding of this disorder and an appropriate approach and therapeutic communication can contribute to a more successful treatment and treatment outcome of this disorder. The activities that nurse performs with the person with narcissistic personality disorder have been shown to be beneficial
Towards automated knowledge-based mapping between individual conceptualisations to empower personalisation of Geospatial Semantic Web
No full textGeospatial domain is characterised by vagueness, especially in the semantic disambiguation of the concepts in the domain, which makes defining universally accepted geo- ontology an onerous task. This is compounded by the lack of appropriate methods and techniques where the individual semantic conceptualisations can be captured and compared to each other. With multiple user conceptualisations, efforts towards a reliable Geospatial Semantic Web, therefore, require personalisation where user diversity can be incorporated. The work presented in this paper is part of our ongoing research on applying commonsense reasoning to elicit and maintain models that represent users' conceptualisations. Such user models will enable taking into account the users' perspective of the real world and will empower personalisation algorithms for the Semantic Web. Intelligent information processing over the Semantic Web can be achieved if different conceptualisations can be integrated in a semantic environment and mismatches between different conceptualisations can be outlined. In this paper, a formal approach for detecting mismatches between a user's and an expert's conceptual model is outlined. The formalisation is used as the basis to develop algorithms to compare models defined in OWL. The algorithms are illustrated in a geographical domain using concepts from the SPACE ontology developed as part of the SWEET suite of ontologies for the Semantic Web by NASA, and are evaluated by comparing test cases of possible user misconceptions
Institutionalization of Imported Rules in the European Union's New Member States: Bringing Politics Back in the Research Agenda
No full textThis paper sets out to explore the puzzle of possible institutionalization or reversal of rules 'imported' by new member states from Central and Eastern Europe during their preparation for accession to the EU. It argues that the institutionalization of formal rules adopted as part of enlargement requirements is not automatic post accession. New formal rules can be reversed, supported by secondary rules and institutionalized or ignored and not implemented. The paper proposes a politics framework that suggests that these different outcomes will be influenced by the environment of weak post communist states and will depend on the area specific configuration of formal and informal veto players and on the EU's ability to impose sanctions. In the case of non acquis imported rules, reversal of formal rules would be possible without sanctions whereas in the case of acquis rules, the likely outcomes are institutionalization or 'empty shells'. Another outcome, 'capture' of the new rules is likely in areas with distributive implications.enlargement; East-Central Europe; acquis communautaire; institutionalisation; administrative adaptation
dimitrova
No full textK e y w o r d s : grehlin signaling, hormone, orexigenic, prostaglaudin, smooth muscle, tromboxane Furthermore, hormones and local mediators often change the conductivity of ion channels in the cell membrane, which can be used as sensors for proper signaling. Our pilot study showed that ghrelin reduces the iberiotoxin-sensitive Ca 2+ -activated potassium current (I K(Ca) ) elicited in freshly isolated smooth muscle cells of human mesenteric arteries via PLD-and PKCdependent mechanism (15). The sarcoplasmic reticulum is also necessary for this signaling as the blockade of sarco-endoplasmic reticulum Ca 2+ ATPase or IP 3 -activated Ca 2+ channels of internal Ca 2+ stores inhibit the effect of ghrelin on I K(Ca) In the present study, we used pharmacological tools to identify the participants of ghrelin signaling and found a second mediator involved. MATERIALS AND METHODS The investigation conformed to the 'Declaration of Helsinki' 1975Helsinki' (revised 1983. Mesenteric arteries were isolated from extracted specimens of human mesentery taken during abdominal surgery on patients -63 men aged 64.6±1.5 years and 43 women aged 59.3±1.9 -and transported to the laboratory in ice-cold saline. Half of the patients were operated for malignant growths (carcinoma sigma) and the rest -for nonmalignant conditions. Contraction studies Segments of mesenteric arteries were dissected, carefully cleaned of adipose and connective tissues and kept in ice-cold low Ca 2+ solution containing (mmol): 118 NaCl, 5 KCl, 1.2 MgCl 2 , 0.16 CaCl 2 , 10 glucose, 1.2 Na 2 HPO 4 and 24 HEPES. Arterial rings (2 mm long) were mounted on a wire-myograph for isometric tension recording DMT, model 410A (Danish Myo Technology, Aarhus, Denmark) whose chamber was filled with the same ice-cold low Ca 2+ solution. After the mounting of the vessel rings, the organ bath solution was replaced with the same solution containing 2.5 mmol CaCl 2 . The bath was heated up to 37°C and continually bubbled with carbogen (95% O 2 and 5% CO 2 ). The isometric force of contraction was recorded using the program Myodaq (DMT, Aarhus, Denmark). The arterial segments were equilibrated for 1 hour at 37°C in a buffer, which was changed at least 3 times during this equilibration period. In most experiments, the endothelium was removed by careful rubbing with a rat whisker. Then vessels were stretched to their optimal lumen diameter, corresponding to 90% of the passive diameter of the vessel at 100 mm Hg. The viability of the preparations was tested twice by application of 10 µmol noradrenaline. The integrity of the endothelium was tested with 10 µmol acetylcholine added to 10 µmol noradrenaline contracted rings. After the viability tests, the strips were contracted with 1 nmol ET-1, which produced relatively stable isometric contractions allowing the study of the effect of the increasing concentrations of ghrelin. The tension reached a steady state in about 40 minutes after the application of ET-1. Then ghrelin was applied to the bath in increasing concentrations of 10, 30, 100, 300 and 1000 nmol, i.e. starting from a value that is about 10 times higher than its plasma level. It led to a significant effect on native artery preparations (with endothelium and in the absence of TTX) at a 30-100 times higher concentration than in human circulation (11). A possible explanation of this result is that ghrelin has a low diffusion rate through the adventitia, which decreases its interaction with receptors of smooth muscle cells when applied to the bath solution. Other researchers have also used higher ghrelin concentrations while studying the effect of ghrelin on vascular preparations (12), probably due to the same reason. It is also possible that ghrelin reaches such values in the smooth muscle layer of the arterial wall due to its paracrine release from human vascular endothelium (16). Additionally, guinea pigs may have a higher plasma level of ghrelin if compared to humans or rats. The ghrelin-induced changes in tension were expressed as a percentage of the maximum tension elicited by 1 nmol ET-1. The influence of different pharmacological agents (inhibitors) on ghrelin effect was studied by means of their addition to the bath about 40 min after ET-1 application and incubated for about 30 min before the application of ghrelin. The effects of inhibitors were studied using several types in vitro preparations: i) native (untreated) preparations of small human mesenteric arteries; ii) endothelium-denuded preparations; iii) native preparations with tetrodotoxin (TTX, 300 nmol) and mainly iv) endotheliumdenuded and TTX-treated preparations. The time control preparations were equally treated, but instead of ghrelin, an equal volume of solvent (deionised water) was added at the same time intervals. The inhibitors and antagonist were applied to block (to switch off) the studied enzyme or receptor activity and not to induce a partial inhibition only. This forced us to use a higher concentration of these substances. On the other hand, the possibility of a non-specific effect of the pharmacological tools restricted us to using them in lower concentrations. Thus, the aim to choose the optimal concentration of each substance for our experiments was not easy. For almost all of the blockers, however, there are at least several studies on arterial preparations in vitro, in some cases with dose-response curves and/or tests for cross-reaction. Besides, the choice of each concentration was based on our earlier experience with a significant part of the substances used either in electrophysiological or functional studies of different vascular beds. Whole-cell patch-clamp experiments This method has been described in detail elsewhere (17). In brief, whole-cell voltage-clamp experiments were performed on single smooth muscle cells, freshly isolated from human mesenteric arteries. The arteries were cut into 3 mm long pieces and placed in 0.1 mmol Ca 2+ -containing physiological salt solution (PSS, for composition see below) warmed to 37°C and containing 1.5 mg ml -1 collagenase II, 1 mg ml -1 papain, 15 µl ml -1 elastase and 1 mg ml -1 albumin. After 30 to 35 min incubation at 37°C with continuous O 2 bubbling, the enzymes were washed away and the tissue pieces triturated 5 times in Ca 2+ -free PSS using a pipette with a small tip opening. The remainder of the tissue was put back into the enzyme-containing solution for another 5 min and then carefully washed with Ca 2+ -free PSS. Single smooth muscle cells were obtained by gentle trituration in 2 ml of the same Ca 2+ -free solution. Cells could be stored for up to 8 hours in this solution at 4-6°C. The external solution (PSS) for single-cell voltage experiments contained (in mmol): 126 NaCl, 5.6 KCl, 10 HEPES, 20 taurine, 20 glucose, 1.1 MgCl 2 , 0.8 CaCl 2 , 5 Napyruvate and pH was adjusted to 7.4 with NaOH. The same solution was used for the isolation of cells. The solutions in the recording pipette contained (in mmol): 125 KCl, 6 NaCl, 10 HEPES, 1 MgCl 2 , 3 EGTA, 0.1 ATP, 5 Na-pyruvate, 5 succinate, 5 oxalacetate, 5 glucose and 2.15 CaCl 2 to give a calculated free Ca 2+ of 200 nmol and pH was adjusted to 7.4 with KOH. Chemicals Most of the substances used for solution preparation were obtained from ICN (Irvine, CA, USA). NaOH, BSA, 2-nitro-4-carboxyphenyl-N,N-diphenylcarbamate (NCDC), pertussis toxin, indomethacin, O-(octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate (D-609), collagenase type II, prostaglandine F 2α (PGF 2α ), (5Z,13E) -(9S,11S,15R)-384 9,15,dihydroxy-11-fluoro-15-(2-indanyl)- Data analysis Current densities were expressed in pA/pF and plotted as functions of the potential applied to obtain data suitable for statistical analysis. The significance of differences between means was assessed using Tukey-Kramer multiple comparison test with p<0.05 regarded significant. The force of contraction was evaluated as a difference in tension (N/m) measured before ET-1 application and the plateau reached afterwards. The contractile effect of ghrelin was expressed as a percentage of the maximal ET-1 induced contraction, taken as 100%. Values were expressed as means±S.E.M. From five to ten human mesenteric arterial preparations (n) were included in the construction of each concentration-response curve of ghrelin. Data were subjected to a comparative statistical analysis one-way ANOVA with Bonferroni correction (p<0.05). RESULTS Octanoyl ghrelin, herein referred to as ghrelin, dosedependently increased the force of contraction of isometric human mesenteric artery preparations constricted with ET-1 The application of increasing doses of ghrelin to external solution containing either NCDC (50 mol) ( The application of increasing concentrations of ghrelin to TTX-and ET-1-containing bath solution failed to influence significantly the force of contraction of endothelium-denuded human mesenteric arteries in the presence of PP2 (10 µmol) -a selective Src family kinase inhibitor The addition of ghrelin (100 nmol) almost entirely inhibited the iberiotoxin-sensitive I K(Ca) recorded during a 500 ms depolarizing pulse to +40 mV from a holding potential of -50 mV (12). Rp-cAMPS (200 µmol), a specific membranepermeable inhibitor of PKA, was without effect on the total outward potassium current (I K ) (n=5), while the subsequent addition of ghrelin (100 nmol) decreased I K to the same degree as in the absence of this PKA inhibitor in single smooth muscle cells from human mesenteric arteries (n=5; p<0.01) DISCUSSION Ghrelin and des-octanoyl ghrelin are equipotent antagonists of ET-1 induced vasoconstriction of human mammary artery (13) while in single smooth muscle cells isolated from human mesenteric arteries des-octanoyl ghrelin blocks the ghrelininduced inhibition of I K(Ca) . This difference supposes the operation of more than one ghrelin receptors in human vascular beds -the des-octanoyl ghrelin-blockable GHS-R1a in human mesenteric arteries and another type in human mammary artery (for a review of ghrelin receptors see 19). Kleinz et al. (13) routinely applied indomethacin to exclude the possibility of endothelium dependent vasodilatation. This treatment however blocks not only endothelial COX1/2 but also those in the tunica media of the artery and thus eliminates the influence of COX1/2 downstream products generated in smooth muscle cells, as suggested by our study. Indeed, such a mechanism is unexpected in blood vessels but is reported in non-vascular smooth muscle (lower esophageal sphincter) that maintains mainly tonic type of contraction similarly to arteries (20). Therefore, it is still difficult to summarize the mechanisms of ghrelin effects on human arteries due to their opposite influences -relaxation and contraction, the different experimental conditions applied and the need for more detailed studies of the intracellular participants. Most often GHS-R1a interacts with heterotrimeric G q/11 proteins and stimulates the G q/11 /PI-PLC/IP 3 +Ca 2+ +DAG/PKC signaling (2). It was reported that the application of a specific PKC inhibitor entirely abolished the effect of ghrelin on I K(Ca) , recorded in single smooth muscle cells of human mesenteric arteries (15). In our study the force of contraction of human mesenteric arteries did not respond to ghrelin application if iberiotoxin or GF109203x were present in the bath solution. Thus, ghrelin requires activation of PKC and suppresses K Ca channels with a large conductance (BK Ca channels) to increase the force of contraction. Ghrelin regulates cAMP/PKA (3-5) and cGMP/PKG signaling (6), which can further influence ion channels. Han et al. (6) reported a ghrelin-induced reduction of voltage-gated I K of rat anterior pituitary tumor (GH3) cells by a PKG-dependent mechanism and Kohno et al. (21) -a ghrelin-induced activation of N-type Ca 2+ channels that required PKA. BK Ca channels are involved in the formation of the spontaneous artery tone, counteract the elevation of the agonist-induced cytosolic free Ca 2+ and participate in the relaxation induced by cAMP/PKAand cGMP/PKG-coupled agonists (22). Therefore, we investigated the participation of both cyclic nucleotides using specific inhibitors Rp-cAMPS for PKA and ODQ for soluble guanylate cyclase. The presence of inhibitors of PKA or soluble guanylate cyclase in the bath solution did not prevent the effect of ghrelin on I K(Ca) . We concluded that the second messengers cAMP and cGMP are not involved in the observed ghrelininduced inhibition of I K(Ca) . On the other hand, in human mesenteric arteries the effect of ghrelin on the force of contraction is blocked by pertussis toxin, which suggests the participation of G i -proteins. In rat islet β-cells ghrelin decreases the insulin secretion by a G αi2 -protein sensitive activation of voltage-gated K + channels and this effect is blocked by D-Lys 3 -GHRP-6, a specific GHS-R1a inhibitor (23). Ghrelin inhibits BK Ca channels in the guinea pig femoral artery via a pertussis toxin and GHS-R1a sensitive pathway (17). Ghrelin also activates G i -protein in cell cultures Ca 2+ released from sarcoplasmic reticulum activates BK Ca channels of smooth muscles cells (24). In human mesenteric arteries IP 3 -sensitive Ca 2+ release is essential for the ghrelininduced decrease of I K(Ca) (15) and for the increase of the force of contraction. Additionally, IP 3 -induced Ca 2+ release from sarcoplasmic reticulum participates in the ET-1 evoked contraction of this vascular bed. Our pharmacological studies suggest that several DAG-producing phospholipases (PI-PLC and PC-PLC) are important in establishing the effect of ghrelin in human mesenteric arteries. We presume that PI-PLC is essential mainly for triggering the contraction (25) and for the IP 3 -induced Ca 2+ release-dependent translocation of PKC to the plasma membrane, while the sustained DAG producer PC-PLC (25) is responsible for the long lasting PKC activation. This suggestion is indirectly supported by the slowly developing inhibition (in 10-14 min) of I K(Ca) by ghrelin in this tissue (15). Using different inhibitors we reveal several new enzymes participating in the ghrelin effect in human mesenteric arteries. Thus, the selective inhibition of MEK or Src kinase entirely blocks the ghrelin-induced contractions in endothelium-denuded human mesenteric arteries with suppressed neurotransmission. The nonselective COX1/2 inhibitor indomethacin eliminates either the ghrelin-induced constriction of human mesenteric arteries or the ghrelin-induced decrease of I K in single smooth muscle cells isolated from the same tissue. All these data suggest the existence of a ghrelin-induced and pertussis toxin-sensitive mechanism, which increases the force of contraction by a consequent activation of Src kinase, MEK and ERK. Similar G iprotein initiated signaling was reported for non-vascular tissues (for review see 26). Next, the stimulated ERK may activate the cytosolic PLA 2 (27), which increases vascular arachidonic acid production -the rate-limiting step for prostaglandin synthesis (28). COX1/2 transform this arachidonic acid into PGE 2 , and then PGE 2 into PGH 2 , which may further yield contracting prostaglandin or thromboxane, as reported for non-vascular smooth muscle It was reported that ghrelin receptor type GHR-R1a has the ability to oligomerize with prostanoid receptors, when they are transiently over-expressed in human embryonic kidney 293 cells (32). The same authors stated that this co-transfection significantly influenced GHR-R1a activity without changes in its affinity for ghrelin. Similarly, as an alternative explanation of our data, it is suggested that ghrelin first binds to GHS-R1a and then activates prostanoid receptor via a direct interaction in the existing GHS-R1a/prostanoid receptor heteromeric complex. If this is the case, the enzymes necessary to demonstrate the effect of ghrelin on the contractile activity (Src kinase, MEK, COX-1 and thromboxane synthase) only support the steady-state thromboxane A 2 production and are not additionally activated by ghrelin. The second explanation of our data, however, seems to be less probable as several new articles report a direct activation of ERK1/2 (3, 7, 33) and Src kinase (34) by ghrelin signaling. Ghrelin decreases the mean arterial pressure of the rat by a COX-insensitive and NOS-sensitive mechanism (35). In rat mesenteric arteries both ghrelin and desacyl ghrelin evoke endothelium-dependent dilation by NOS-and COX-insensitive mechanism (36). Ghrelin inhibits the contraction of human aortic smooth muscle cells by cAMP/PKA pathway activation (4). Ghrelin and desacyl ghrelin antagonize the ET-1-induced contraction of human internal mammary artery (13). Ghrelin decreases the mean arterial pressure in humans as well (11). On the other hand, contractile effects of ghrelin were reported in guinea pig femoral (37) and renal (17) arteries and in rat coronary artery (38). Ghrelin increases the force of contraction of human mesenteric arteries partially constricted with ET-1. The effect is stronger in endothelium-denuded preparations and most pronounced in endothelium-denuded artery segments with blocked action potential propagation of perivascular neurons. These data point to a relaxing effect of ghrelin via endothelium and axonal projections in adventitia, which antagonize the direct and stronger contractile action of ghrelin on the smooth muscle layer of the vascular wall. Additionally, if compared to native preparations during the first half of the experiments, the higher force of contractions of endothelium-denuded human mesenteric arteries suggest that endothelium, as well as perivascular neurotransmission are functional, i.e. they are not badly damaged by the therapy before the surgical intervention or during the transportation. It can be concluded that ghrelin either increases or decreases the force of contraction of arteries depending on their type and the species. Thus, ghrelin and desacyl ghrelin may influence the artery resistance similarly to other regulators of the circulation with opposite effects on different vascular beds. For example, catecholamines redistribute the blood flow throughout the body, depending on the physiological needs, via different adrenergic receptors and intracellular mechanisms. In summary, ghrelin has been shown to increase the force of contraction of human mesenteric arteries by a novel mechanism that requires active Src kinase, MEK, COX-1 and thromboxane synthase and that depends on the release of a local mediator -a T prostanoid receptor agonist. Additionally, our data suggest a novel physiological regulation, in which an empty stomachinitiated increase of ghrelin secretion reduces the abdominal circulation in adult humans until next meal. Acknowledgement
What a Difference Context Makes: Comparing Communication Strategies of Migration NGOs in Two Neighboring Countries
No full textThis research study compared non-governmental organizations (NGOs) working in the area of migration in two neighboring countries – Bulgaria and Turkey. Utilizing in-depth interviews with 39 NGO professionals in both countries, the analysis identified critical differences in public opinion dynamics, organizational structures and interdependencies, and government relationships. Further analysis unveiled how the local socio-economic and political context had impacted NGO communication strategies as well as the specific communication channels, public engagement activities, and social media campaigns in each country. Implications for communication scholarship during times of increasing migration flows and globalization are discussed.This article is published as Dimitrova, D., Ozdora-Aksak, E., What a Difference Context Makes: Comparing Communication Strategies of Migration NGOs in Two Neighboring Countries. Journal of Borderlands Studies. 31 Dec 2022. Latest Articles. https://doi.org/10.1080/08865655.2022.2161065. Posted with permission. © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.<br
Kate Dimitrova. Review of "The Bayeux Tapestry: New Interpretations" by Martin K. Foys, Karen Eileen Overbey, and Dan Terkla.
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