2,884 research outputs found
Dienstordnung für die Diener der k. k. Universitäts-Bibliothek in Wien
No full textDIENSTORDNUNG FÜR DIE DIENER DER K. K. UNIVERSITÄTS-BIBLIOTHEK IN WIEN
Dienstordnung für die Diener der k. k. Universitäts-Bibliothek in Wien ( - )
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Title page (1r)
Dienstordnung für die Diener der k. k. Universitäts-Bibliothek in Wien. (1r)
1. Organismus. (1r)
2. Bestimmung. (1v)
3. Rang und Bezüge. (2r)
4. Anstellungs-resp. Aufnahms-Bedingungen (2r)
5. Dienstesobliegenheiten. (2v)
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Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling
No full textAbstract not availableFrances Corrigan, Yue Wu, Jonathan Tuke, Janet K. Coller, Kenner C. Rice, Kerrilyn R. Diener, John D. Hayball, Linda R. Watkins, Andrew A. Somogyi, Mark R. Hutchinso
sj-docx-1-wso-10.1177_17474930231184366 – Supplemental material for Early or late initiation of dabigatran versus vitamin-K-antagonists in acute ischemic stroke or TIA: The PRODAST study
No full textSupplemental material, sj-docx-1-wso-10.1177_17474930231184366 for Early or late initiation of dabigatran versus vitamin-K-antagonists in acute ischemic stroke or TIA: The PRODAST study by Gerrit M Grosse, Anika Hüsing, Andreas Stang, Nils Kuklik, Marcus Brinkmann, Darius Nabavi, Paul Sparenberg, Karin Weissenborn, Klaus Gröschel, Georg Royl, Sven Poli, Dominik Michalski, Christoph C Eschenfelder, Christian Weimar and Hans-Christoph Diener in International Journal of Stroke</p
Identification of the cir1 disease resistance gene in Arabidopsis thaliana
No full textIncludes bibliographical references.Plants rely on an elaborate multi-layered defence system to perceive and effectively respond to disease causing pathogens. The defence-related cir1 (constitutively induced resistance 1) mutant was first isolated in an effort to identify components of the Arabidopsis thaliana defence system essential for resistance against pathogens. The cir1 mutant has previously been described as having increased resistance to the virulent bacterial pathogen Pseudomonas syringae pv. tomato DC3000 and oomycete pathogen Hyaloperonospora parasitica Noco2 and was shown to constitutively express salicyclic acid-, jasmonic acid/ethylene- and reactive oxygen intermediate-responsive genes. Genetic analysis and mapping studies of the mutation revealed that it is recessive and may be encoded by one of eight genes located within a 309.10 kb region on the lower arm of chromosome four
Multi-parameter flow cytometric analysis of uterine immune cell fluctuations over the murine estrous cycle
No full textAbstract not availableKerrilyn R. Diener, Sarah A. Robertson, John D. Hayball, Erin L. Lousber
Properties of exotic matter for heavy ion searches
No full textWe examine the properties of both forms of strange matter, small lumps of strange quark matter (strangelets) and of strange hadronic matter (Metastable Exotic Multihypernuclear Objects: MEMOs) and their relevance for present and future heavy ion searches. The strong and weak decays are discussed separately to distinguish between long-lived and short-lived candidates where the former ones are detectable in present heavy ion experiments while the latter ones in future heavy ion experiments, respectively. We find some long-lived strangelet candidates which are highly negatively charged with a mass to charge ratio like a anti deuteron (M/Z 2) but masses of A=10 to 16. We predict also many short-lived candidates, both in quark and in hadronic form, which can be highly charged. Purely hyperonic nuclei like the (2 02 ) are bound and have a negative charge while carrying a positive baryon number. We demonstrate also that multiply charmed exotics (charmlets) might be bound and can be produced at future heavy ion colliders
Unravelling the complexity of cancer-immune system interplay
No full textThe immune system has an intricate and complex relationship with tumorigenesis; while it has the capacity to identify and eliminate cancerous cells, the emergence of a tumor signifies its failure to do this. Thus, the immune–tumor interplay is paradoxical as through initial suppression of tumor growth, an immunologically silent or even suppressive tumor evolves. Furthermore, certain immune processes, such as chronic inflammation and immunosuppression, can facilitate malignant progression. Nevertheless, immunotherapeutic approaches can manipulate the immune milieu to improve the therapeutic outcomes of cancer treatments. Furthermore, particular conventional cancer therapies also have immunostimulatory properties in their own right. An in-depth understanding of the intimate involvement of the immune system in tumorigenesis and the potential to manipulate this interaction to improve disease outcomes will enable the development of new and broadly effective cancer therapies.Cara K Fraser, Michael P Brown, Kerrilyn R Diener and John D Haybal
Cryoelectron tomography of radial spokes in cilia and flagella
No full textRadial spokes (RSs) are ubiquitous components in the 9 + 2 axoneme thought to be mechanochemical transducers involved in local control of dynein-driven microtubule sliding. They are composed of >23 polypeptides, whose interactions and placement must be deciphered to understand RS function. In this paper, we show the detailed three-dimensional (3D) structure of RS in situ in Chlamydomonas reinhardtii flagella and Tetrahymena thermophila cilia that we obtained using cryoelectron tomography (cryo-ET). We clarify similarities and differences between the three spoke species, RS1, RS2, and RS3, in T. thermophila and in C. reinhardtii and show that part of RS3 is conserved in C. reinhardtii, which only has two species of complete RSs. By analyzing C. reinhardtii mutants, we identified the specific location of subsets of RS proteins (RSPs). Our 3D reconstructions show a twofold symmetry, suggesting that fully assembled RSs are produced by dimerization. Based on our cryo-ET data, we propose models of subdomain organization within the RS as well as interactions between RSPs and with other axonemal components
Response to the letter by Dame
No full textIn his letter, Christof Dame1 builds on and supports the points made in the discussion part of our recent erythropoietin (EPO) stroke article.2 Especially the exploratory analysis presented in this article, showing potential beneficial effects of EPO treatment in patients nonqualifying for recombinant tissue plasminogen activator (rtPA),2,3⇓ should definitely stimulate further basic research to better understand and define potential contraindications to EPO treatment for future EPO stroke trials. For this purpose, we decided to share with your readers a new set of data obtained during our extensive post hoc evaluation of the study that might give additional insight into the risk profile of EPO treatment
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