205 research outputs found
Thiocyanate-treated perovskite-nanocrystal-based light-emitting diodes with insight in efficiency roll-off
No full textDurability Study on Self Compacting Concrete with Mineral Admixture
No full textSelf compacting concrete can be placed and compacted under its own weight without any vibration and without segregation or bleeding. The use of mineral admixture such as fly ash, GGBS, etc. as partial replacement of cement in SCC can bring down cost. The use of industrial waste such as fly ash, GGBS, etc in the binder of concrete reduces the storage, disposal and environmental problems. The most beneficial property with M SAND addition to the concrete in the hardened state are the tensile strength, impact strength, the toughness and the energy absorption capacity. In the present study the mix design for M50 grade SCC was first carried out in accordance with EFNARC guidelines. The cement will be replaced with GGBS and fine aggregate get replaced with manufacturing sand Test such as slump flow,V funnel were carried out on fresh concrete and the optimum dosage of super plasticizer was found and cubes were cast for 7,28,56 days for the mix ratio 1 1.40 1.27 0.34. The influence of GGBS on the workability, mechanical strength and durability aspects like water absorption test, sulphate attack test, acid resistance test,rapid chloride penetration test , sorptivity test , linear polarization resistivity test and alkalinity test of self compacting concrete are studied. Boopathi V | Sharmila Devi K "Durability Study on Self Compacting Concrete with Mineral Admixture" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-3 , April 2019, URL: https://www.ijtsrd.com/papers/ijtsrd23226.pd
Regulation of miR106b cluster through the RB pathway: mechanism and functional targets.
No full textThe RB pathway plays a critical role in proliferation control that is commonly subverted in tumor development. However, restoration of RB pathway function can be elicited in many tumor cells by the inhibition of CDK4/6 activity that leads to dephosphorylation of RB and subsequent repression of E2F-mediated transcription. In this context, active RB/E2F complexes inhibit the expression of a critical program of coding genes that promote cell cycle progression. However, the non-coding RNA target genes downstream from RB that could be relevant for tumor biology remain obscure. Here, miRNA gene expression profiling identified the miR106b cluster as being efficiently repressed with CDK4/6 inhibition in an E2F and RB-dependent manner. Importantly, the miR106B-cluster is intragenic of MCM7, and through a series of functional studies, the basis of MCM7 regulation and concordant expression of the miRNA species within the 106b cluster was determined. Importantly, RB-mediated repression of the 106b cluster enhances the transcript levels of p21Cip1 and PTEN. These data provide a mechanistic basis for cross-talk between the RB pathway and p21 and PTEN through the regulation of the MCM7/miR106b locus. © 2013 Landes Bioscience
Synthesis, crystal structure, thermal and nonlinear optical properties of new metal-organic single crystal: Tetrabromo (piperazinium) zincate (II) (TBPZ)
No full textInquiry of inclined magnetic field effects on Walter –B nanofluid flow with heat generation / absorption
No full textThe article deals with Walter-B nanoliquid flow towards a extending surface with inclined magnetic field effects. Thermal relaxation analysis is made by non fourier heat flux model. Radiation, heat generation / absorption impacts are included. The non linear Partial governing systems are rebuild into nonlinear ordinary systems with the assist of proper similarity transformations. The graphical results are portrayed for velocity, concentration and temperature profile. The physical entitles of heat and mass transfer rates are graphically reported. The comparission with previous results notified the excellent agreement.Loganathan, K.Nithyadevi, N.Boopathi, P.Mohana, K
Prospective Outcome Analysis of Various Methods of Management of Compound Supracondylar Fractures of Femur
No full textINTRODUCTION: Fractures of the distal femur are severe injuries that result in varying degrees of permanent disability. As the number of highways become more and high speed driving increases, the potential for devastating injuries like open fractures of the femur with polytrauma also increase substantially. These injuries present with varied combination of bony and soft tissue loss. Bony injury could range from a simple supracondylar fracture pattern to a severely comminuted injury with intraarticular extension and bone loss. There is further understandable reluctance on the part of most Orthopaedic surgeons to primarily use bone graft for open injuries with bone loss.With changing expectations and rise in high velocity injuries, fracture fixation and rehabilitation in open distal femur fracture injuries however is still a challenge.
AIM:
The aim of the study is to analyze prospectively the results of outcomes of various methods of management of Compound Supracondylar fractures of femur.
OBJECTIVES:
To evaluate the result of open Supracondylar fractures of femur in terms of, union, infection, range of motion of knee, complications and need for bone grafting. This study also tries to bring insight into the unpublished area of literature to highlight the importance of need for further research in open supracondylar fractures of femur.
MATERIALS AND METHODS: This is a prospective study of 20 patients with open supracondylar and distal femoral fractures treated with rigid internal fixation using locking compression plate,dynamic condylar screw fixation and knee spanning external fixator and minimal internal fixation with cancellous screws and k wires at Institute of Orthopaedics and Traumatology,Madras Medical College & Government General Hospital, Chennai from May 2008 to September 2010. The patients were selected based on the inclusion and exclusion criteria as given below: Inclusion Criteria - All patients above 18 years with open supracondylar femur fractures extending upto 15 cm from the articular surface. 1. Compound grade I,II,IIIA,IIIB (Gustilo anderson’s classification) of supracondylar fracture of femur. 2. Type A1, A2, A3, B1, B2, B3, and C1,C2,C3 (Muller’s Classification), 3. reporting within 12 hours after Injury. Exclusion Criteria - 1. Associated Multiple Comorbid Conditions, 2. Associated Tibial Plateau Fractures, 3. Associated Vascular Injuries, 4. Pathological Fracture.
RESULTS: 20 cases (four groups) results were studied. Group 1treated with initial wound debridement and followed by either internal fixation with dynamic condylar screw fixation or locking compression plating with an average period of gap between the initial debridement, skeletal traction and definitive fixation was about 3 weeks. Group 2 of patients were treated with initial wound debridement and external fixator with minimal internal fixation for maintaining the articular surface as well as to prevent the flexion of the distal fragment. Group 3 was treated with minimal internal fixation alone. Group 4 was treated with external fixation alone.
CONCLUSION: Though we are able to achieve satisfactory union in compound supracondylar fractures of femur, the functional outcome still remains to be poor in severe (Grade IIIB) cases.
External fixation can only be used as a temporary modality and not as a definitive fixation and we found better results when external fixation was converted early to definitive stable internal fixation. Amount of soft tissue injury correlates with poor results. Grade of compound wound influences more than the fracture pattern in the final outcome. Delay in stable fixation and non compliance to the early Rehabilitation physical therapy also influences the final functional
outcome
Study on Early Release and Skin Grafting of Upper Eyelid Burns for Prevention of Ectropion
No full textINTRODUCTION:
Burns trauma is as old as the discovery of fire in the history of
mankind. Eye lid burns are more common among the eye traumas.
They induce different effects on the ocular structures, depending
on the type of burns. The eyelid plays a vital role in protecting
vision, which is the most important sensation. No doubt the eyelid is
compared to a mother protecting a child amidst all circumstances- day
in and day out. Eyelids are delicate, complicated in their anatomy and
physiology. Eye lids are more prone to be damaged in the effort to save the eyeball.
No day passes without winking of the eye. The eyelids do their
function involuntarily without our knowledge, yet they can co-operate
with us in-voluntary closure also. In ocular burns in an effort to save
the eyeball the lids take the toll. Ocular burns injury can be in the
form of acid burns, thermal burns or hot liquid.
This is a study of injury of the eyelid due to burns and the
effect of early intervention to restore the normal anatomy in retaining the function of eye.
AIM OF THE STUDY:
1. To evaluate the efficacy of the collagen application immediately on admission, & early release and skin
grafting for the prevention of ectropion in upper eyelid burns.
2. Release incision and apply collagen on admission in III degree flame burns and acid burns and early STSG within 6 days for upper eyelid.
OBJECTIVE:
1. To find out the simple procedure to prevent (or) minimize problem in acute phase of upper eyelid burn.
2. To find out the optimum reconstructive procedure.
3. To find out post operative complication and factor to prevent.
MATERIALS AND METHODS:
In our study we have included 20 patients with deep partial
thickness and full thickness upper eyelid burns cases examined &
admitted at Burns, plastic & Reconstructive surgery department
Kilpauk medical college and hospital Chennai- 10, between
September 2006 to March 2009. A detailed history was taken with
reference to the presenting complaint of the patient, the cause and
duration and any previous treatment taken for it.
All patients underwent through clinical examination. Both eyes
are examined, properly documented and photographs are taken.
Inclusion Criteria:
1. Patients with deep partial thickness and full thickness upper eyelid burns.
2. Eye lid burns with less then 50 % of the total body surface area burns,
3. Upper eye lid burns with out major corneal complications are included.
4. Upper eyelid burns due to flame burns and acid burns.
Exclusion Criteria:
1. Upper Eye lid burn with more then 50% of the total body surface area burns.
2. Upper Eye lid burn with Epidermal and superficial partial thickness burns.
3. Upper Eye lid burn Patient with associated systemic disease like Diabetes, Hypertension, and severe systemic illness.
4. Upper Eye lid burn with age less then 13 and age more then 60 are excluded.
5. Upper Eye lid burn with previous ocular surgery.
6. Upper Eye lid burn with severe respiratory burns.
Eyelid burns early release and collagen sheet applied on admission and on 6th post burn day split thickness skin graft was applied. The split thickness skin grafts used for early grafting.
OBSERVATION:
Total number of burn patient treated: 4819. 20 cases of upper eyelid burns were selected for release and
grafting. 17 cases were flame burns and 2 cases were acid burns one case of scalds injury.
All cases that were taken up for study were free from co morbid conditions like diabetes mellitus, IHD, renal, liver pathology. All cases taken up for study were present with the complaints of
inability to open the eyelid because of edema. Symptoms of corneal irritation conjunctival congestion were noted in 18 cases. There was no limbal ischemia even in acid burns. Anterior chamber, pupil, fundus were normal in all the cases. There was no punctual obstruction or cicatrisation. All cases were evaluated by ophthalmologist. In all our cases because of oedema of eyelid initial evaluation of vision was not
possible. All cases were under systemic antibiotic cover, anti inflammatory and analgesics. All cases had topical antibiotic eye drops All the procedures were done under IV anesthesia. Donor site of skin graft was upper arm in 10 cases and thigh in 10 cases. 100% skin graft take in 17 patients. Donor site healing was completed in 10days no donor site morbidity was observed.
CONCLUSION:
1. Release incision and collagen application on the day of amission for deep partial thickness full thickness and chemical upper eyelid burn and early split thickness skin graft within 6-10 days prevent the post burn cicatricial ectropion.
2. It is a simple procedure to prevent the post burn cicatricial ectropion.
3. This procedure definitely prevent the period of wound inflamation and further complications.
4. This procedure optimize the eyelid function.
A deep partial thickness and full thickness burn of the eyelids
will lead to development of contraction and cicatricial ectropion and
subsequent exposure keratitis, followed by blindness. For this reason
deep partial and full thickness eyelid burns should be grafted as early as possible.
The role of surgery in the treatment of those complex injury
continue to evolve to incorporate refined concepts of tissue
preservation, wound bed preparation and early attention to functional
and aesthetic parameter. Social reintegration, psycho social support,
and new pain control strategies have dramatically improved the
quality of life for our patients during and after the acute course of
care. In eyelid burn early release and grafting improved the ocular function
Comparative study of Outcome in Thermal Burns Patients Managed With and Without Parenteral Antibiotics for First 48 Hours
No full textDataset of natural antisense transcripts in P. vivax clinical isolates derived using custom designed strand-specific microarray
No full textAbstractNatural antisense transcripts (NATs) have been detected in many organisms and shown to regulate gene expression. Similarly, NATs have also been observed in malaria parasites with most studies focused on Plasmodium falciparum. There were no reports on the presence of NATs in Plasmodium vivax, which has also been shown to cause severe malaria like P. falciparum, until a recent study published by us. To identify in vivo prevalence of antisense transcripts in P. vivax clinical isolates, we performed whole genome expression profiling using a custom designed strand-specific microarray that contains probes for both sense and antisense strands. Here we describe the experimental methods and analysis of the microarray data available in Gene Expression Omnibus (GEO) under GSE45165. Our data provides a resource for exploring the presence of antisense transcripts in P. vivax isolated from patients showing varying clinical symptoms. Related information about the description and interpretation of the data can be found in a recent publication by Boopathi and colleagues in Infection, Genetics and Evolution 2013
Demand Response Unit Commitment Problem Solution for Maximizing Generating Companies’ Profit
No full textOver the recent years there has been an immense growth in load consumption due to which, Load Management (LM) has become more significant. Energy providers around the world apply different load management concepts and techniques to improve the load profile. In order to reduce the stress over the load management, Demand Response Unit Commitment (DRUC), a new concept, has been implemented in this paper. The main feature of this concept is that both the energy providers and consumers must participate in order to get mutual benefits hence maximizing each of their profits. In this paper we discuss the time-based Demand Response Program since there is no penalty observed in this program. When the Demand Response was combined with Unit Commitment and compiled it was observed that a satisfactory solution resulted, which is proved to be mutually beneficial for both Generating Companies (GENCOs) and their customers. Here, we have used a Cat Swarm Optimization (CSO) technique to find the solution for the DRUC problem. The results are obtained using CSO technique for UC problem with and without DR program. This is compared with the results obtained using other conventional methods. The test system considered for the study is IEEE39 bus system
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