412 research outputs found
Chimera and globally clustered chimera: impact of time delay
No full textFollowing a short report of our preliminary results [Sheeba et al., Phys. Rev. E 79, 055203(R) (2009)], we present a more detailed study of the effects of coupling delay in diffusively coupled phase oscillator populations. We find that coupling delay induces chimera and globally clustered chimera (GCC) states in delay coupled populations. We show the existence of multiclustered states that act as link between the chimera and the GCC states. A stable GCC state goes through a variety of GCC states, namely, periodic, aperiodic, long- and short-period breathers and becomes unstable GCC leading to global synchronization in the system, on increasing time delay. We provide numerical evidence and theoretical explanations for the above results and discuss possible applications of the observed phenomena
Role of combination bortezomib and pegylated liposomal doxorubicin in the management of relapsed and/or refractory multiple myeloma
No full textJatin J Shah1, Robert Z Orlowski1,2, Sheeba K Thomas11Departments of Lymphoma/Myeloma; 2Experimental Therapeutics, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USAAbstract: The first in class proteasome inhibitor bortezomib (B) received its initial regulatory approval for therapy of patients with multiple myeloma (MM) in the relapsed/refractory setting. Modulation of proteasome function, however, is also a rational strategy for chemosensitization, and a variety of agents have shown synergistic activity with bortezomib pre-clinically, including anthracyclines. This formed the basis for evaluation of a regimen of bortezomib with pegylated liposomal doxorubicin (PLD). PLD+B, in a phase I study, induced a predictable and manageable toxicity profi le, and showed encouraging anti-MM activity. In a recent international, randomized phase III trial, PLD+B demonstrated a superior overall response rate and response quality compared to bortezomib alone, as well as a longer time to progression, duration of response, progression-free survival, and overall survival. Sub-analyses revealed benefits in almost all clinically relevant subgroups, including several which would be considered to have high-risk disease. These findings have led to the establishment of the PLD+B regimen as one of the standards of care for patients with relapsed and/or refractory myeloma. Efforts are now underway to build on this combination further by adding other active anti-myeloma agents. In this review, we will discuss the role of PLD+B as an important addition to our therapeutic armamentarium for patients with MM.Keywords: multiple myeloma, relapsed/refractory, pegylated liposomal doxorubicin, bortezomib, Doxil®, Velcade&reg
Neuronal synchrony during anesthesia : a thalamocortical model
No full textThere is growing evidence in favor of the temporal-coding hypothesis that temporal correlation of neuronal discharges may serve to bind distributed neuronal activity into unique representations and, in particular, that theta (3.5–7.5 Hz) and delta (0.5 , 3.5 Hz) oscillations facilitate information coding. The theta- and delta-rhythms are shown to be involved in various sleep stages, and during anesthesia, they undergo changes with the depth of anesthesia. We introduce a thalamocortical model of interacting neuronal ensembles to describe phase relationships between theta- and delta-oscillations, especially during deep and light anesthesia. Asymmetric and long-range interactions among the thalamocortical neuronal oscillators are taken into account. The model results are compared with experimental observations. The delta- and theta-activities are found to be separately generated and are governed by the thalamus and cortex, respectively. Changes in the degree of intraensemble and interensemble synchrony imply that the neuronal ensembles inhibit information coding during deep anesthesia and facilitate it during light anesthesia
Motive Factors of B.Ed Student Teachers for Choosing Teaching as their Calling
No full text<div><p><em>It is obvious that quality of teaching force is not governed only by the qualification, pedagogical knowledge and teaching skill of teachers, but also their enthusiasm, motivation, dedication and commitment in teaching. Student teachers have a substantial impact on the education of future generations. In order for a system of teacher education to be effective, it needs to recognize and build on the characteristics and motivations that student teachers bring with them when they enter teacher education program after their completion of graduation or post graduation. Holistic teacher building is necessary and therefore teacher education needed more emphasis than mere training by high positive motivation of the student teachers for choosing the teaching as their calling. The data for the present study were collected from a population of student teachers. In the present study, Survey Method is employed to describe and interpret. The sample size chosen for B.Ed., student teachers are 500 (250 Male and 250 Female) of the Pudukkottai District, Tamil Nadu, India. The findings revealed that female student teachers have manifested significantly higher level in all the selected variables when compared to their counter parts. The independent variables such as positive and negative emotion, altruism, moral value, teacher's attitude and personal and social influence correlate significantly with motivation positively. The coefficient of determination R square measures the goodness-of-fit with the value of 0.249 and this means that the independent variables contributes to the extent of 24.9% to motivation and it is significant at 1% level. </em></p></div></jats:p
Keyword Extraction Using Particle Swarm Optimization
No full textAbstractWithout formal structure data are those that have no prearranged form or structure and are full of textual data. Typical unstructured systems include emails, reports, telephone or messaging conversations, etc. The main goal of this work is to extract the keywords from a conversation using particle swarm optimization. Keywords are grouped together under their classification and then suggested to the user. In existing work, using diverse keyword extraction, to find topic modelling information, representation of the main topics of transcript and diverse keyword selection. It maximizes the coverage of topics that are automatically recognized in transcript of conversation fragment. Once a set of keywords is extracted, it is clustered according to their user queries and recommended to the user. At the end of result, a single implicit query cannot improve user's satisfaction with the recommended documents. So, swarm intelligence technique is to be applied, it will minimize redundancy in a short list of Keywords and provide accurate query result compared to greedy algorithm
Role of the Pelvis in the Mechanics and Energetics of Human Walking
No full textPeople vary widely in body shape and size, with considerable sex differences in body dimensions. The pelvis, in particular, shows the most pronounced sex-specific differences within the locomotor anatomy, with females typically having a wider pelvis relative to lower limb length than males. Two key characteristics of walking are stride length and its associated metabolic cost. Both pelvis width and lower limb length influence stride length, and the contribution of pelvic rotation in the transverse plane to stride length is termed the ‘pelvic step.’ Biomechanically, both pelvic rotation and pelvis width contribute to pelvic step; however, it is unclear how the pelvis contributes to the walking stride in individuals with different pelvis widths. While lower limb length has been positively linked to better walking economy, the limb functions in concert with pelvis motion rather than in isolation. The independent and combined effects of pelvis width and lower limb length on metabolic cost during walking remain poorly understood. Moreover, several clinical conditions are associated with increased pelvic rotation and elevated walking cost; thus, a better understanding of normal pelvis function in walking can enhance the clinical utility of gait analysis. Therefore, this dissertation investigates the role of pelvis width, both independently and relative to lower limb length, on walking mechanics and metabolic energy expenditure.
Musculoskeletal models are often used to analyze gait but are typically derived from male anatomy; therefore, we developed a female-specific musculoskeletal model to better reflect sex-specific pelvis morphology. Three-dimensional walking kinematics were captured using a motion capture system, and metabolic energy expenditure was measured using a portable metabolic system while 15 female and 15 male participants walked on a treadmill with embedded force platforms. We found that individuals with a relatively wider pelvis tend to rotate their pelvis more during walking, resulting in a greater pelvic step. However, relative pelvis width explained only a modest portion of the variance in pelvic step, with no significant sex differences observed. In contrast, pelvic rotation accounted for the largest variance in pelvic step, and its relationship with pelvic step was significantly stronger in females than in males. Despite this sex difference in the relationship, the average pelvic step amplitude did not differ significantly between sexes. Overall, differences in pelvis size and shape had a relatively small influence on gait kinematics with no meaningful sex differences.
We also found that in females, a shorter lower limb and a wider pelvis relative to limb length were associated with a lower metabolic cost of walking. In males, however, a longer lower limb and a narrower relative pelvis width were associated with lower cost. This suggests that pelvis and lower limb proportions influence metabolic cost differentially by sex. Still, as with pelvic step, relative pelvis width explained only a small to moderate portion of the variance in metabolic cost. The lowest walking costs observed among females (with shorter limbs and wider pelves) were similar to that among males (with longer limbs and narrower pelves), indicating that more than one body design can lead to economical walking. We conclude that relative pelvis width affects both pelvic step and metabolic energy consumption during walking, with some sex-specific differences. However, these effects were modest, likely reflecting the fact that pelvis morphology is only one of many factors influencing the way we walk and the associated metabolic cost.PhDMovement Science PhDUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/199364/1/sheeba_1.pd
Sharp Bounds of Kulli–Basava Indices in Generalized Form for k-Generalized Quasi Trees
No full textMolecular descriptors are a basic tool in the spectral graph, molecular chemistry, and various other fields of mathematics and chemistry. Kulli–Basava KB indices were initiated for chemical applications of various substances in chemistry. For simple graph G, KB indices in generalized forms are KB1ϱG=∑gh∈EGSeg+Sehϱ and KB2ϱG=∑gh∈EGSeg.Sehϱ, where Seg=∑e∈NegdGe, and for edge e=g,h, the degree is dGe=dGg+dGh−2 and ϱ≠0 is any real number. The graph G is said to be a k−generalized quasi tree if for the vertex set Uk⊂G having Uk=k, G−Uk is a tree and for Uk−1⊂VG having Uk−1=k−1, G−Uk−1 is not a tree. In this research work, we have successfully investigated sharp bounds of generalized KB indices for k-generalized quasi trees where ϱ≥1. Chemical applications of the generalized form are also studied for alkane isomers with scatter diagrams and residuals
Design considerations for the use of laser-plasma accelerators for advanced space radiation studies
No full textWe present design considerations for the use of laser-plasma accelerators for mimicking space radiation and testing space-grade electronics. This novel application takes advantage of the inherent ability of laser-plasma accelerators to produce particle beams with exponential energy distribution, which is a characteristic shared with the hazardous relativistic electron flux present in the radiation belts of planets such as Earth, Saturn and Jupiter. Fundamental issues regarding laser-plasma interaction parameters, beam propagation, flux development, and experimental setup are discussed
Mental Health of Different Types of College Students
No full textMental health is defined as a state of well-being in which an individual realizes his or her abilities, can cope with the normal stresses of life, can learn and work productively and can make a contribution to his or her community. As mental health of the students, is measured by life satisfaction, positive effect and depression which constitute the two way of viewing the mental health in the positive as well as negative. In this present study normative Survey method was adopted. Higher education students of Chennai District were used as a sample for the study. Data is collected from 822 college students of which Arts and Science college students is 147, Engineering college students is 196 and Education college students is 479 from different type of colleges are involved in this present study. Result of the present study is there is a significant difference between gender, locality, type of institution and types of colleges. The dimensions of mental health is well correlated with each other
Technological Singularity in Sujatha Ranganathan’s En Iniya Iyanthira and Meendum Jeeno
No full textThe research paper aims at exploring the narrative aesthetics of Tamil science fiction in which the author takes twenty-first-century politics in India within the context of technological singularity. The article presents the political situation and totalitarianism in the age of technological singularity. The research focuses on the social impacts of artificial intelligence’s ability to read, learn, think, and act against its pre-programmed mechanism. A robotic dog struggles to restore a democratic political system from autocracy. The dystopian fictions “En Iniya Iyanthira” and “Meendum Jeeno” written by Sujatha Ranganathan depict the cognitive power of super intelligence behind a woman’s political actions to protect the people of India from exploitation, and corruption to create a better future. The paper demonstrates what a world without individual freedom looks like under the digital surveillance system of a totalitarian regime. The paper raises the question of what happens when a robot develops its rationality and mimics human behaviour. In these fictions, humans attempt to destroy the robotic dog. The robotic dog reaches a standard where nothing can destroy it. The paper explores the ways the robotic dog gains the knowledge to understand and practice the concept of humanity. The paper concludes with the post-humanistic conflicts between a woman and a robotic dog in emotional, ethical, and political aspects
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