198 research outputs found
Acid-base balance
No full textAcid-base balance is the balance of the hydrogen ion concentrations in body fluids. The hydrogen ion (H+) concentration in body fluids is regulated within a narrow range to achieve normal metabolic and enzymatic functions as well as critical functions including fertilization, growth, protein synthesis, and cell volume regulation. Acid-base balance is under a multi-system control involving the brain, lungs, liver and kidneys. Many acid-base disorders occur due to the loss of body fluids or electrolytes from the body or their entry into the body. Electroneutrality and buffer systems are the key factors in ensuring this balance
Grafisch Radardisplay voor de ATC-Simulator
No full textEnige tijd geleden is een Traffic Control simulator ontwikkeld door een groep specialisten, waaronder ook mijn mentoren. Deze simulator simuleert een compleet ATCsysteem. Vliegtuigen kunnen opstijgen en vliegen naar gewenste plaatsen, ook een Anti-Collision algoritme is hierin opgenomen om ongewenste situatie's te voorkomen. De oorspronkelijke uitvoering van de simulator laat in tabelvorm de gegevens en toestand van de vliegtuigen zien. Enkele voorbeelden van deze gegevens zijn: positie, snelheid, hoogte, type, label en plaats van bestemming van het vliegtuig. Om deze gegevens duidelijker weer te geven, dan de huidige tabelvorm, is gekozen voor een grafische presentatie van dit onderdeel.Electrical Engineering, Mathematics and Computer ScienceTelecommunicatie- en Verkeersbegeleidingssysteme
THE PREVENTIVE EFFECT OF DOPAMINE INFUSION ON RENAL ISCHEMIA & REPERFUSION INJURY IN RATS WITH ABDOMINAL COMPARTMENT SYNDROME
No full textTriterpene Saponins from Tetrapanax papyriferum K. KOCH.
No full textFour new oleanane-type saponins, papyrioside LA-LD, were isolated from the leaves of Tetrapanax papyriferum. The structures of these new compounds were elucidated as 11 alpha-hydroxy-3,21-dioxo-olean-12-en-28-oyl-alpha-L-rhamnopyranosyl-( 1-->4)-(6-O-acetyl-beta-D-glucopyranosyl)-(1-->6)-beta-D-glucopyranoside, 11 alpha-methoxy-3,21-dioxo-olean-12 -en-28-oyl-alpha-L-rhamnopyranosyl-(1-->4)-(6-O-acetyl-beta-D-glucopyranosyl)-(1-->6)-beta-D-glucopyranoside, 3 alpha-hydroxy-11 alpha-methoxy-21-oxo-olean-12-en-28-oyl-alpha-L-rhamnopyranosyl-(1-->4)-(6-O-acetyl-beta-D-glucopy- ranosyl)-(1-->6)-beta-D-glucopyranoside and 21 alpha-hydroxy-11 alpha-methoxy-3-oxo-olean-12-en-28-oyl-alpha-L-rhamnopy- ranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopy-ranoside, respectively, on the basis of spectroscopic and chemical evidence
Parental satisfaction assessment after pediatric procedural sedation: there are still issues to address
No full textDOPAMINE:A PREVENTIVE AGENT FOR MESENTERIC ISCHEMIA & REPERFUSION INJURY IN ABDOMINAL COMPARTMENT SYNDROME
No full textThe influence of the COVID-19 pandemic on videolaryngoscopy: a cross-sectional before-and-after survey
No full textBackground: Guidelines and consensus statements recommend the use of videolaryngoscopes (VLs) in airway management of patients with COVID19. However, there is a lack of knowledge about which types of videolaryngoscopes are used, differences of use between countries, and how the COVID19 pandemic influenced their use. The primary aim of this beforeandafter crosssectional survey study was to assess the frequency of the use of videolaryngoscopy in the operation theatres in different countries. Also, the preferred characteristics of videolaryngoscopes were assessed. Methods: With Ethics Committee approval, a questionnaire was distributed among anaesthesiologists through the European Airway Management Society’s network in 2019 before and in 2021 during the COVID19 pandemic. Responses to the questions were analysed and presented as descriptive statistics. Results: We reached out to 791 anaesthesiologists; 155 (19.5%) returned the first questionnaire, and 91 (11.5%) returned the second survey. Videolaryngoscopes were used in 24.1% of cases before COVID19 and in 43.1% after the pandemic (P < 0.001). We revealed that the availability of videolaryngoscopes increased to 100% in all centres during the pandemic. Routine use of videolaryngoscopes in all cases increased from 12.5% to 38.9%. The type of videolaryngoscope and the blade preference did not change during this period (P= 1.000). Conclusions: This survey reflects that the COVID19 pandemic significantly increased the availability and use of videolaryngoscopes in operating theatres, and that more anaesthesiologists now use them routinely in all cases. The preferred type of VL or blade did not change during the pandemic
Airway management education: an update. It is high time to realize professional airway training as an art
No full textWOS: 000448470300003Airway training is one of the key element residents need to master during their anesthesiology teaching program. Airway-related disasters during this training might be prevented by the supervision of highly skilled airway experts as teachers. In the present day, a multimodal blended training approach helps in the planning for airway management teaching including both technical and non-technical skills. "Difficult Airway Response Team", advanced airway management rotation, case presentations to learn presenting and augmenting about clinical approaches, formalized airway training certificate based on defined competences, hands-on practices, virtual reality airway simulators, high-fidelity full-scale simulators, fresh cadavers, specific "Train the Airway Trainer Courses" resulting in certified "Airway Teachers", and ultimate delibrate practice on models and patients are cornerstones of teaching and learning airway management. Even though the working hours of the residents in the operating room are reduced due to legislation, it is still possible to provide high quality anesthesiology training to manage the airway by creating the triangle of airway management, quality improvement and patient safety. Ultimately the provision of higher quality airway training needs to be translated into improved patient safety embedded in high end healthcare organizations
Activation properties of trigeminal motoneurons in participants with and without bruxism
No full textIn animals, sodium-and calcium-mediated persistent inward currents (PICs), which produce long-lasting periods of depolarization under conditions of low synaptic drive, can be activated in trigeminal motoneurons following the application of the monoamine serotonin. Here we examined if PICs are activated in human trigeminal motoneurons during voluntary contractions and under physiological levels of monoaminergic drive (e. g., serotonin and norepinephrine) using a paired motor unit analysis technique. We also examined if PICs activated during voluntary contractions are larger in participants who demonstrate involuntary chewing during sleep (bruxism), which is accompanied by periods of high monoaminergic drive. In control participants, during a slowly increasing and then decreasing isometric contraction, the firing rate of an earlier-recruited masseter motor unit, which served as a measure of synaptic input to a later-recruited test unit, was consistently lower during derecruitment of the test unit compared with at recruitment (Delta F = 4.6 +/- 1.5 imp/s). The Delta F, therefore, is a measure of the reduction in synaptic input needed to counteract the depolarization from the PIC to provide an indirect estimate of PIC amplitude. The range of Delta F values measured in the bruxer participants during similar voluntary contractions was the same as in controls, suggesting that abnormally high levels of monoaminergic drive are not continually present in the absence of involuntary motor activity. We also observed a consistent "onion skin effect" during the moderately sized contractions (<20% of maximal), whereby the firing rate of higher threshold motor units discharged at slower rates (by 4-7 imp/s) compared with motor units with relatively lower thresholds. The presence of lower firing rates in the more fatigue-prone, higher threshold trigeminal motoneurons, in addition to the activation of PICs, likely facilitates the activation of the masseter muscle during motor activities such as eating, nonnutritive chewing, clenching, and yawning.Canadian Institute of Health ResearchCanadian Institutes of Health Research (CIHR) [MOP-106549]; Turkish Scientific and Technological Research OrganizationTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [Tubitak-107S029- SBAG-3556]; Alberta Innovates: Health Solutions; Alberta Paraplegic Foundation; European Research Council (ERC) via the ERC Advanced Grant DEMOVEEuropean Research Council (ERC) [267888]This work was supported by the Canadian Institute of Health Research (MOP-106549; to M. A. Gorassini) and a Turkish Scientific and Technological Research Organization (Tubitak-107S029- SBAG-3556) grant (to K. S. Turker). Salary support was provided by Alberta Innovates: Health Solutions (to M. A. Gorassini and J. M. D'Amico) and the Alberta Paraplegic Foundation (to J. M. D'Amico), and S,.U. Yavuz was supported by the European Research Council (ERC) via the ERC Advanced Grant DEMOVE (No. 267888)
Regional convergence and the causal impact of migration on regional growth rates
No full textThe standard growth theory predicts that allowing for labor mobility across regions would increase the speed of convergence in per capita income levels and that migration has a negative causal impact on regional growth rates. Although the empirical literature has uncovered some evidence for the former implication, the latter has not been verified empirically. This paper provides empirical evidence for the negative causal impact of migration on provincial growth rates in a developing country with a high level of internal migration that is characterized by unskilled labor exiting rural areas for urban centers. We utilize instrumental variables estimation method with an instrument unique to the country examined and also control for provincial fixed effects.Regional convergence; Regional growth; Internal migration; Fixed effects; IV estimation
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