426 research outputs found
Fostering Child Development by Improving Care Quality
No full textHermenau K, Goessmann K, Rygaard NP, Landolt MA, Hecker T. Fostering Child Development by Improving Care Quality. Trauma, Violence, & Abuse. 2016;18(5):544-561
N: Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferongamma transcription
No full textWe reported previously that daily injections of isophane insulin prevented both hyperglycemia and insulitis in non-obese diabetic (NOD) mice (Atkinson, M., N. Maclaren; and R. Luchetta. 1990. Diabetes. 39:933-937). The possible mechanisms responsible include reduced immunogenicity of pancreatic fl-cells from ",B-cell rest " and induced active immunoregulation to insulin (Aaen, K., J. Rygaard, K. Jo
Resolution studies of fluid flow models near the core-mantle boundary through bayesian inversion of geomagnetic data
No full textRadiosensitivity of small-cell lung cancer xenografts compared with activity of c-myc, N-myc, L-myc, c-raf-1 and K-ras proto-oncogenes
No full textUdgivelsesdato: 1991-Sep-9Oncogenes of the myc family c-raf-1 and K-ras have been reported to modulate radiosensitivity. We examined the possible relationship between in vivo radiosensitivity to single-dose irradiation with 3-10 Gy, and activity of these proto-oncogenes in 2 sets of small-cell lung cancer (SCLC) xenografts, the CPH and the GLC series. CPH-54A and CPH-54B are in vitro-derived subclones of a SCLC cell line, while the GLC tumours were established as cell lines from a patient during longitudinal follow-up. Both tumours were later transferred into nude mice. CPH-54A was more sensitive to single-dose irradiation than CPH-54B, while, with respect to the 3 GLC tumours examined, GLC-16 was most sensitive, followed by GLC-14 and GLC-19. The CPH tumours expressed similar amounts of c-myc and c-raf-1 mRNA, and neither expressed N-myc or L-myc. GLC-14 expressed N-myc and c-raf-1 mRNA but no c-myc. GLC-16 and GLC-19 expressed identical amounts of c-raf-1 and high levels of c-myc mRNA, but neither expressed N-myc or L-myc. None of the tumours was mutated at codon 12 or K-ras. Our results show that SCLC xenografts with different radiosensitivity may express identical amounts of some of the proto-oncogenes reported to modulate radiosensitivity. Thus, factors other than activation of the examined proto-oncogenes must be involved in causing the differences in radiosensitivity found in the SCLC xenografts. Possible long-term effects of irradiation on proto-oncogene expression was examined in xenografts of GLC-16, following regrowth after single-dose irradiation. No long-term difference in expression of c-raf-1 or c-myc mRNA was detected between control tumours and tumours irradiated with 5 or 10 Gy
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University of California Radiation Laboratory Report UCRL-3104
No full textThesis describing the Auger effect in the heaviest elements. The elements detailed in the report are ytterbium, polonium, and uranium. Measurements of K fluorescence yields and K Auger electron intensity ratios are given
Restitution of streptozotocin induced diabetes mellitus in nude mice with pancreatic grafts from the rat.
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A Rapid Method for Identification of Murine Cells in Human Malignant Tumours Grown in Nude Mice
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