29 research outputs found
Evaluation of toxicological and antioxidant potential of Nardostachys jatamansi in reversing haloperidol-induced catalepsy in rats
No full textA S Rasheed1, S Venkataraman1, K N Jayaveera2, A Mohammed Fazil3, K J Yasodha3, M A Aleem3, M Mohammed3, Z Khaja3, B Ushasri3, H A Pradeep3, M Ibrahim31Department of Pharmacology and Toxicology, C L Baid Metha College of Pharmacy, Jyothi Nagar, Thoraipakkam, Chennai, Tamil Nadu, India; 2Department of Chemistry, Jawaharlal Nehru Technology University, Anantapur, Andhra Pradesh, India; 3Nizam Institute of Pharmacy and Research Center, Deshmukhi, Pochampally (M), Near Ramoji Film City, Nalgonda, (AP), IndiaAbstract: An aqueous root extract from Nardostachys jatamansi was investigated for its antioxidant and anticataleptic effects in the haloperidol-induced catalepsy rat model of the disease by measuring various behavioral and biochemical parameters. Catalepsy was induced by administration of haloperidol (1 mg/kg, ip) in male albino rats. A significant (P < 0.01) reduction in the cataleptic scores were observed in all the drug-treated groups as compared to the haloperidol-treated group; with maximum reduction observed in the Nardostachys jatamansi (250 and 500 mg/kg body weight) administered group. To estimate biochemical parameters: the generation of thiobarbituric acid reactive substances (TBARS); reduced glutathione (GSH) content and glutathione-dependent enzymes; catalase; and superoxide dismutase (SOD), in the brain were assessed. Haloperidol administration increased generation of TBARS and significantly reduced GSH, which were restored to near normal level with the Nardostachys jatamansi treatment. Catalase and SOD levels were also increased to normal levels, having been reduced significantly by haloperidol administration. Our findings of behavioral studies and biochemical estimations show that Nardostachys jatamansi reversed the haloperidol-induced catalepsy in rats. We conclude that the antioxidant potential has contributed to the reduction in the oxidative stress and catalepsy induced by haloperidol administration.Keywords: Nardostachys jatamansi, antioxidant, toxicological, haloperidol and cataleps
Synthesis of 4<i>H</i>-imidazo[2,1-<i>c</i>][1,4]benzoxazin-4-yl acetic acids and esters as possible COX-2 inhibitors
No full text792-795A series of 4H-imidazo[2,1-c][1,4]benzoxazin-4-yl acetic acids and esters (7 and 8) have been synthesized from methyl -(3,4-dihydro-3-oxo-2H-1,4-benzoxazin-2-yl)acetates 5 and their COX-2 inhibition activities are evaluated
TRANSDERMAL DRUG DELIVERY PATCHES: A REVIEW
Get PDFFor thousands of years, human civilizations have applied substances to the skin as cosmetic and medicinal agents. However, it was not until the twentieth century that the skin came to be used as a drug delivery route. In fact, Merriam Webster dates the word “transdermal†to 1944 highlighting that it is a relatively recent concept in medical and pharmaceutical practice. Transdermal drugs are selfâ€contained, discrete dosage form. Drug delivery through the skin to achieve a systemic effect without producing any fluctuations in plasma concentration of the drug. Topical administration of therapeutic agents offers many advantages over conventional oral and invasive methods of drug delivery. And also provide controlled release of the drug for extended period of the time. This review article covers brief outline advantages, skin pathways for transdermal drug delivery systems (TDDS), various components of transdermal patch, and approaches for preparation of transdermal patches, evaluation of transdermal system, general clinical considerations in the use of tdds and limitation of tdds. Key words: Transdermal, Permeation pathways, Drug delivery, Matrix, ReservoirÂ
HEPATOPROTECTIVE ACTIVITY OF HYDRO-ALCOHOLIC EXTRACT OF WHOLE PLANT OF SOLANUM DULCAMARA L. AND NEPHROLEPIS CORDIFOLIA (L) C. PRESL AGAINST PARACETAMOL INDUCE HEPATOTOXICITY IN ALBINO RATS
Get PDFÂ Objective: To investigate the effect of hepatoprotective activity of hydro-alcoholic extract of Solanum dulcamara L. and Nephrolepis cordifolia (L)C. Presl against paracetamol induced hepatotoxicity in rats.Methods: Albino rats of either sex were divided into nine groups and treated for 7 days. Group I and II served as normal and toxic control, Group IIIwere treated with Silymarin (100 mg/kg), and Group IV to IX were treated with 200, 400 and 600 mg/kg hydro-alcoholic (70%v/v) extract ofS. dulcamara (HASD) and hydro-alcoholic (70%v/v) extract of N. cordifolia (HANC) respectively. The biochemical markers like serum glutamicpyruvictransaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT), alkaline phosphatase (ALP), bilirubin (total and direct), total protein,triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-densitylipoprotein cholesterol (VLDL-C). The in vivo antioxidant activity was determined by estimating the tissue levels of glutathione (GSH), superoxidedismutase (SOD), catalase (CAT) and lipid peroxidation (LPO). Histopathology of liver was also carried out.Results: The HASD and HANC (200, 400 and 600 mg/kg) produced significant effect by decreasing the activity or level of SGOT, SGPT, ALP, billirubinand total protein, where decrease in total protein level in liver, TG, TC, LDL-C and VLDL-C levels and increase in the HDL-C. And decrease tissue LPO,while it significantly increased the levels of tissue GSH, SOD and CAT in a dose-dependent manner.Conclusion: From the present study it can be concluded that hydro-alcoholic extract of S. dulcamara L. and N. cordifolia (L) C. Presl whole plantpossesses hepatoprotective activity against paracetamol induced hepatotoxicity.Keywords: Hepatoprotective, In-vivo antioxidant activity, Paracetamol, Solanum dulcamara L. and Nephrolepis cordifolia (L) C. Presl, Silymarin
Effect of Bile Salts on Transbuccal Permeability of Carbamazepine through Porcine Buccal Mucosa
No full textInfluence of strong alkaline substances (sodium carbonate and sodium bicarbonate) in mixing water on strength and setting properties of concrete
No full text123-128The quality of mixing and curing water plays a vital role in production and application of concrete. In the present study, the effect of strong alkaline substances like sodium carbonate (Na2CO3) and sodium bicarbonate (NaHCO3) on setting time and strength development of concrete is assessed under the laboratory conditions. The results indicate that Na2CO3 in deionised water accelerates the initial as well as final setting times whereas the other compound NaHCO3 retards the initial and final setting times in all concentrations. Na2CO3 and NaHCO3 in deionised water decrease the compressive and tensile strength of concrete specimens significantly at 28 days and 90 days. Comparison of the results of strong alkaline compounds with those of the control mix reveals that both Na2CO3 and NaHCO3 decrease the compressive and tensile strength significantly. The rate of decrease is increasing with the increase in concentration. The present work analyses the hydration characteristics of concrete using the technique of X-ray diffraction (XRD) and useful conclusions are obtained regarding the influence of strong alkaline substances
STUDIES ON GROUNDWATER QUALITY IN ANANTAPUR DISTRICT
Get PDFABSTRACT: Ground water is the main principal source for drinking water and other activities in Andhra Pradesh. It is the basic duty of every individual to conserve water resources. The present study attempts to bring an acute awareness among the people about the quality of ground water by taking water samples from 33 specific locations in Anantapur district to characterize the physicochemical parameters of Ground water. To assess the quality of groundwater, each parameter was compared with the standard desirable limit of that parameter in drinking water as prescribed by different agencies. This paper is a new study on water quality parameters in analyzing Anantapur district drinking water
Evaluation of Abelmoschus starch as tablet disintegrant
No full text342-347Seed
starch (16.0%w/w) obtained from Abelmoschus moschatus Linn. (Malvaceae) was employed as a
disintegrant to paracetamol tablets at concentrations of 2.5-10.0% w/w. The
granules prepared by wet granulation technique were evaluated for percentage of
fines and flow properties. Tablet properties including thickness, content
uniformity, average weight and weight variation, hardness, friability,
disintegration time and drug dissolution were evaluated. With increasing Abelmoschus starch concentrations, the
formulations disintegrate and dissolve rapidly due to its low viscosity and
high swelling factor. The disintegrant efficiency of extracted starch was
compared with that of the corn starch in tablets prepared using magnesium
stearate, aerosol, corn starch and microcrystalline cellulose as diluent, drug
and binder, respectively. The disintegration time for tablet formulations prepared
using 10% w/w extracted starch was less (160 s) than that of the tablet
formulations prepared using corn starch as a disintegrant (166 s). Dissolution
studies showed that the drug release from the tablet containing 7.5 to 10% w/w
was 70-90% in 1 hr. Tablets at 10% w/w concentration showed more optimum
results as tablet disintegrant. Studies indicated that A. moschatus starch
is a superior disintegrant in tablet formulation
A validated stability-indicating isocratic LC method for levofloxacin in the presence of degradation products and its process-related impurities
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