34,785 research outputs found
Direct colorimetric detection of amplified nucleic acids based on thiol-labeled primers and unmodified gold nanoparticles
No full textMetal ions-induced unnatural polymerase activity and its use for the design of molecular logic gates
No full textColorimetric gold cross-linking detection (GCD) of target DNA combined with isothermal target and probe amplification (iTPA)
No full textMetal Ions-Triggered Polymerase Activity and Its Use for the Development of Molecular Logic Gates
No full textWe described a new strategy in which a polymerase enzyme is controlled to accomplish an unnatural extension reaction even at the mismatched site of a primer with template DNA. The validity of this novel concept was systematically demonstrated by using metal ions (Hg2 + and Ag + ) to intentionally trigger an unusual polymerase activity at respective T-T and C-C mismatched primers on the basis of their specific interactions with the respective mismatched base pairs (T-T and C-C). A novel strategy to construct molecular scale logic gates was also developed based on the unnatural polymerase activity induced by metal ions. The successful operation of the key logic gates was demonstrated by rationally designing primers and employing metal ions (Hg2 + and Ag + ) as inputs. In addition, this new concept could be applied to the development of a molecular translator, which could generate the functional nucleic acids such as aptamers and deoxyribozymes
Label free colorimetric detection of sequence specific Chlamydia Trachomatis DNA using gold nanorods
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A Graphene Oxide-based Autocatalytic Isothermal Signal Amplification Method for DNA detection
No full textGold nanoparticles - Based colorimetric single nucleotide polymorphisms genotyping utilizing allele-specific PCR
No full textNucleic acids-regulated photo-polymerization of diacetylene (DA) monomers on a nanoporous membrane : A new colorimetric diagnosis of target nucleic acids
No full textEnhanced PNA Microarray Presenting High Specificity Combined with S1 Nuclease for SNPs Detection
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