21,692 research outputs found
Jun Tan interview for the China Boom Project
No full textJun Tan, a migrant worker who works at a manufacturing factory, was interviewed by the Asia Society staff in Chengdu, China in March 2009.Transcript and interviewee's bio are available.Original video interviews are available at the Asia Society.The China Boom Project classified this interviewee’s field as Vox Populi
Dialogical Skirmishes
No full textTan was guest editor for 'And Now China?', a special print edition of the Ctrl+P journal, which critically responded to the celebratory rhetoric’s of ‘China Now’ and other celebratory markers of China's global ascent in 2008. As well as the introductory article 'Dialogical Skirmishes', Tan also interviewed Hans Ulrich Obrist
Evidence for erbium-erbium energy migration in erbium(III) bis(perfluoro-p-tolyl)phosphinate
No full textCopyright 2008 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. This article appeared in Applied Physics Letters 92, 103303 (2008) and may be found at
sj-docx-1-tan-10.1177_17562864231165561 – Supplemental material for The severity of corneal nerve loss differentiates motor subtypes in patients with Parkinson’s disease
No full textSupplemental material, sj-docx-1-tan-10.1177_17562864231165561 for The severity of corneal nerve loss differentiates motor subtypes in patients with Parkinson’s disease by Ning-Ning Che, Qiu-Huan Jiang, Shuai Chen, Si-Yuan Chen, Zhen-Xiang Zhao, Xue Li, Jian-Jun Ma, Jie-Wen Zhang, Rayaz A. Malik and Hong-Qi Yang in Therapeutic Advances in Neurological Disorders</p
sj-docx-1-tan-10.1177_17562864211070449 – Supplemental material for Improving pediatric multiple sclerosis interventional phase III study design: a meta-analysis
No full textSupplemental material, sj-docx-1-tan-10.1177_17562864211070449 for Improving pediatric multiple sclerosis interventional phase III study design: a meta-analysis by Jennifer S. Graves, Marius Thomas, Jun Li, Anuja R. Shah, Alexandra Goodyear, Markus R. Lange, Heinz Schmidli, Dieter A. Häring, Tim Friede and Jutta Gärtner in Therapeutic Advances in Neurological Disorders</p
sj-docx-2-tan-10.1177_17562864211070449 – Supplemental material for Improving pediatric multiple sclerosis interventional phase III study design: a meta-analysis
No full textSupplemental material, sj-docx-2-tan-10.1177_17562864211070449 for Improving pediatric multiple sclerosis interventional phase III study design: a meta-analysis by Jennifer S. Graves, Marius Thomas, Jun Li, Anuja R. Shah, Alexandra Goodyear, Markus R. Lange, Heinz Schmidli, Dieter A. Häring, Tim Friede and Jutta Gärtner in Therapeutic Advances in Neurological Disorders</p
Free thinking - running
No full textWe've been running for two million years give or take. Shahidha Bari and Laurence Scott explore contemporary running as solitary inspiration and communal activity with the Geographer and 1999 Scottish Hill Running Champion, Hayden Lorimer, the artists Kai Syng Tan and Angus Farquhar, and the literary scholar and bare-foot artiste, Vybarr Cregan-Reid. Conversation ranges from feeling empowered on city streets to teaming up with the wind to the horrid history of the treadmill and explore whether Running deserves better representation in the arts. Guests: Vybarr Cregan-Reid - author of Footnotes How Running Makes Us Human Angus Farquhar, Creative Director of NVA Public Art, author of a blog 'The Grim Runner' Hayden Lorimer Running Geographer Kai Syng Tan, Artist and curator of a biennial festival Run Run Run Producer: Jacqueline Smith
Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene
No full textG protein-coupled receptor regulation of gene transcription primarily occurs through the phosphorylation of transcription factors by MAPKs. This requires transduction of an activating signal via scaffold proteins that can ultimately determine the outcome by binding signaling kinases and adapter proteins with effects on the target transcription factor and locus of activation. By investigating these mechanisms, we have elucidated how pituitary gonadotrope cells decode an input GnRH signal into coherent transcriptional output from the LH beta-subunit gene promoter. We show that GnRH activates c-Src and multiple members of the MAPK family, c-Jun NH2-terminal kinase 1/2, p38MAPK, and ERK1/2. Using dominant-negative point mutations and chemical inhibitors, we identified that calcium-dependent proline-rich tyrosine kinase 2 specifically acts as a scaffold for a focal adhesion/cytoskeleton-dependent complex comprised of c-Src, Grb2, and mSos that translocates an ERK-activating signal to the nucleus. The locus of action of ERK was specifically mapped to early growth response-1 (Egr-1) DNA binding sites within the LH beta-subunit gene proximal promoter, which was also activated by p38MAPK, but not c-Jun NH2-terminal kinase 1/2. Egr-1 was confirmed as the transcription factor target of ERK and p38MAPK by blockade of protein expression, transcriptional activity, and DNA binding. We have identified a novel GnRH-activated proline-rich tyrosine kinase 2-dependent ERK-mediated signal transduction pathway that specifically regulates Egr-1 activation of the LH beta-subunit proximal gene promoter, and thus provide insight into the molecular mechanisms required for differential regulation of gonadotropin gene expression
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