25,584 research outputs found
Fu Jun Li et al Supplemental data.docx
No full textThese are supplemental figures including supplemental Fig. S1, Fig. S2 and Fig. S3. Three figures will be published with the manuscript
Irreversible JNK1-JUN inhibition by JNK-IN-8 sensitizes pancreatic cancer to 5-FU/FOLFOX chemotherapy
No full textOver 55,000 people in the United States are diagnosed with pancreatic ductal adenocarcinoma (PDAC) yearly, and fewer than 20% of these patients survive a year beyond diagnosis. Chemotherapies are considered or used in nearly every PDAC case, but there is limited understanding of the complex signaling responses underlying resistance to these common treatments. Here, we take an unbiased approach to study protein kinase network changes following chemotherapies in patient-derived xenograft (PDX) models of PDAC to facilitate design of rational drug combinations. Proteomics profiling following chemotherapy regimens reveals that activation of JNK-JUN signaling occurs after 5-fluorouracil plus leucovorin (5-FU + LEU) and FOLFOX (5-FU + LEU plus oxaliplatin [OX]), but not after OX alone or gemcitabine. Cell and tumor growth assays with the irreversible inhibitor JNK-IN-8 and genetic manipulations demonstrate that JNK and JUN each contribute to chemoresistance and cancer cell survival after FOLFOX. Active JNK1 and JUN are specifically implicated in these effects, and synergy with JNK-IN-8 is linked to FOLFOX-mediated JUN activation, cell cycle dysregulation, and DNA damage response. This study highlights the potential for JNK-IN-8 as a biological tool and potential combination therapy with FOLFOX in PDAC and reinforces the need to tailor treatment to functional characteristics of individual tumors
Corynoneura prolata Fu & Wang & Fang & Xiao & Fu & Lin 2020, sp. n.
No full textCorynoneura prolata Fu, sp. n. Fig. 5 Type material. Holotype male (NKU: G5A6), CHINA: Zhejiang Province, Jinhua City, Pan’an County, Dapanshan Mountains, 120°31′30″E, 28°47′30″N, a.s.l. 800 m, 17–21.VII.2012, light trap, leg. Xiao-Long Lin. Etymology. From Latin, prolatus, extended, elongated, referring to phallapodeme very long, extending beyond posterior margin of tergite IX. Diagnostic characters. The male imago is characterized by having an antenna with ten flagellomeres, AR 0.36; superior volsella undeveloped, and inferior volsella absent; sternapodeme inverted V-shaped; phallapodeme very long, extending beyond posterior margin of tergite IX, strongly curved with projection for joint with sternapodeme placed pre-lateral. Description. Adult male (n = 1). Total length 1.17 mm. Coloration. Head and thorax dark brown. Abdomen yellow brown. Head. Antenna with ten flagellomeres, AR 0.36, ultimate flagellomere 98 µm long, ultimate flagellomere not expanded apically (Fig. 5B). Tentorium and cibarial pump as in Fig. 5C, tentorium 115 µm long; 15 µm wide. Anterior margin of cibarial pump concave. Length of palpomeres (in µm): 15; 13; 18; 20; 38. Palpomere 5/3 ratio: 2.1. Thorax. Dorsocentrals 7. Scutellum with 2 setae. Wing (Fig. 5A). VR 3.2. Cu/wing length 0.52; C 100 µm long; Cu 420 µm long; wing width/wing length: 0.42. Costa with 5 setae. Legs. Fore legs and mid legs lost. Hind tibia expanded, with comb of 12 setae, one seta near spur strongly Sshaped. Lengths and proportions of legs as in Table 4. Hypopygium (Fig. 5 D–E). Tergite IX and laterosternites IX without long setae. Tergite IX medially incurved. Superior volsella undeveloped. Inferior volsella absent. Phallapodeme 63 µm long, strongly curved with projection for joint with sternapodeme placed pre-lateral, extending beyond posterior margin of tergite IX. Sternapodeme inverted V-shaped. Gonostylus strongly curved tapering, 28 µm long, with inner lobe in median part; megaseta 5 µm long. HR 2.43; HV 4.19. Remarks. This species is similar to Corynoneura sorachibecea Sasa & Suzuki, 2001 by having an antenna with ten flagellomeres, inferior volsella absent, sternapodeme curved into V-shaped, and gonostylus with inner lobe in median part. The new species can be separated from the latter by having small AR 0.36 and phallapodeme extending beyond posterior margin of tergite IX in this species, while AR of 0.56–0.61, phallapodeme not extending beyond posterior margin of tergite IX in C. sorachibecea.Published as part of Fu, Yue, Wang, Xin-Hua, Fang, Xiang-Liang, Xiao, Yun-Li, Fu, Jun & Lin, Xiao-Long, 2020, Corynoneura Winnertz (Diptera, Chironomidae, Orthocladiinae) from Zhejiang Province, China, pp. 83-96 in Zootaxa 4890 (1) on pages 90-91, DOI: 10.11646/zootaxa.4890.1.4, http://zenodo.org/record/430156
Istiochrysis gen. nov., a new chrysidid genus from Oriental China (Hymenoptera, Chrysididae)
No full textRosa, Paolo, Feng, Jun, Xu, Zai-Fu (2016): Istiochrysis gen. nov., a new chrysidid genus from Oriental China (Hymenoptera, Chrysididae). Zootaxa 4111 (5): 591-597, DOI: 10.11646/zootaxa.4111.5.
Supplemental Material, supplementary_table_1-TCRT-17-0031.R3 - DCE-MRI-Derived Volume Transfer Constant (K<sup>trans</sup>) and DWI Apparent Diffusion Coefficient as Predictive Markers of Short- and Long-Term Efficacy of Chemoradiotherapy in Patients With Esophageal Cancer
No full textSupplemental Material, supplementary_table_1-TCRT-17-0031.R3 for DCE-MRI-Derived Volume Transfer Constant (Ktrans) and DWI Apparent Diffusion Coefficient as Predictive Markers of Short- and Long-Term Efficacy of Chemoradiotherapy in Patients With Esophageal Cancer by Zhi-Min Ye, Shu-Jun Dai, Feng-Qin Yan, Lei Wang, Jun Fang, Zhen-Fu Fu, and Yue-Zhen Wang in Technology in Cancer Research & Treatment</p
Two new species of Calanthe (Orchidaceae; Epidendroideae) from China
No full textZhai, Jun-Wen, Chen, Li-Jun, Xing, Fu-Wu, Liu, Zhong-Jian (2013): Two new species of Calanthe (Orchidaceae; Epidendroideae) from China. Phytotaxa 123 (1): 51-55, DOI: 10.11646/phytotaxa.123.1.
SOUP
No full textConcomitant with the tremendous growth of online social networking (OSN) platforms are increasing concerns from users about their privacy and the protection of their data. As user data management is usually centralized, OSN providers nowadays have the unprecedented privilege to access every user's private data, which makes large-scale privacy leakage at a single site possible. One way to address this issue is to decentralize user data management and replicate user data at individual end-user machines across the OSN. However, such an approach must address new challenges. In particular, it must achieve high availability of the data of every user with minimal replication overhead and without assuming any permanent online storage. At the same time, it needs to provide mechanisms for encrypting user data, controlling access to the data, and synchronizing the replicas. Moreover, it has to scale with large social networks and be resilient and adaptive in handling both high churn of regular participants and attacks from malicious users. While recent works in this direction only show limited success, we introduce a new, decentralized OSN called the Self-Organized Universe of People (SOUP). SOUP employs a scalable, robust and secure mirror selection design and can effectively distribute and manage encrypted user data replicas throughout the OSN. An extensive evaluation by simulation and a real-world deployment show that SOUP addresses all aforementioned challenges
Fu Describing About the Author Himself: A Focus on Ban Gu "You tong fu"
No full textFrom Later Han dynasty onwards, the number of fu describing about the author himself has increased. There are several possible reasons for this, but the most important reason is probably that there was no other genre through which one could express oneself except for fu in this period. For instance, the fiveword poetry was still in the middle way of establishing its own style at that moment. Moreover, in Former Han, there were few opportunities for authors to talk about themselves in detail in fu, because the main readers were emperors and kings of countries. In Later Han, the readers had become more diverse. That is probably the reason why more fu began to mention about the authors themselves in this period. Ban Gu (32-92), who is a representative scholar of Later Han and also a man of letters, expressed his aim by writing "You tong fu". Its main content is that though one's encounter with a disaster or felicity is not always derived from our behavior, we have to have a strong will and take action to overcome disasters. This idea is supported by Ban Gu's experiences of not attaining his aim. Such experiences are common in Chinese authors. One of the earliest examples is Chu Ci. Also, Chu Ci is the one of the origins of fu. It is surprising that authors expressed things about themselves mostly in fu describing journeys. It may be easier to understand this tendency if we think they substituted the heaven wander in Chu Ci with a ground journey. Chu Ci was a model for authors to express their aim which could not come true, even if the journey on the ground and the wander in heaven are different
Optimizing data center traffic of Online Social Networks
No full textWith a huge number of users and a very large scale of data, an Online Social Network (OSN) service has to partition its data among multiple servers inside a data center. As data are often partitioned randomly, the response time in accessing the data is however unpredictable. Researchers have proposed social locality to address this concern: if a server hosts the master replica of a user's data, it must also host a replica (either master or slave) of every friend of this user, thus enabling convenient access of all of them on the same server. However, doing so comes with two overheads: the replication storage and the traffic of maintaining replica consistency. Existing work focuses on the former, but overlooks the latter that can consume considerable network resources. In this paper, we study social-locality-aware partitioning of the OSN data while meeting diverse performance goals of data center networks. We formulate the traffic optimization problem and propose a new traffic-aware data partitioning algorithm. Through the evaluations with a large-scale, real-world Twitter trace, we further show that, compared with state-of-the-art algorithms, our algorithm significantly reduces traffic without deteriorating the load balance among servers and causing extra replication storage
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