529 research outputs found
Erb & Obleser: Chapter on Neural Filters (2018/2020)
No full textPreprint of book chapter by Julia Erb & Jonas Obleser for the forthcoming issue of The Cognitive Neurosciences VIth edition (MIT Press, 2020), edited by David Poeppel, George Mangun, and Michael Gazzanig
Erb & Obleser: Chapter on Neural Filters (2018/2020)
No full textPreprint of book chapter by Julia Erb & Jonas Obleser for the forthcoming issue of The Cognitive Neurosciences VIth edition (MIT Press, 2020), edited by David Poeppel, George Mangun, and Michael Gazzanig
Erb & Obleser: Chapter on Neural Filters (2018/2020)
No full textPreprint of book chapter by Julia Erb & Jonas Obleser for the forthcoming issue of The Cognitive Neurosciences VIth edition (MIT Press, 2020), edited by David Poeppel, George Mangun, and Michael Gazzanig
Markenzeichen: Unverkennbar!
No full textDie meisten Menschen wollen dazugehören, aber dennoch unverwechselbar sein, so Sozialpsychologe Dr. Hans-Peter Erb. Der Hamburger Universitätsprofessor und Vorurteilsforscher weiß, wie wichtig für die Weiterentwicklung einer Gesellschaft gerade auch die Menschen sind, die ihre Individualität in besonderem Maße ausleben: Dieses Bedürfnis hängt sehr stark mit dem Hang zu Kreativität zusammen. Und davon leben Innovationen, die uns voranbringen.N
The Thyroid Hormone Receptor Alpha Locus and White Matter Lesions: A Role for the Clock Gene REV-ERB?
No full textBackground: Thyroid disorders are associated with an increased risk of cognitive impairment and Alzheimer's disease. Both small vessel disease and neurodegeneration have a role in the pathogenesis of cognitive impairment and Alzheimer's disease. Thyroid hormone receptor alpha (TR?) is the predominant TR in brain. The circadian clock gene REV-ERB? overlaps with the TR? gene and interferes with TR? expression. Limited data are available on the role of the TR?/REV-ERB? locus in small vessel disease and neurodegeneration. We therefore studied genetic variation in the TR?/REV-ERB? locus in relation to brain imaging data, as early markers for small vessel disease and neurodegeneration. Methods: Fifteen polymorphisms, covering the TR?/REV-ERB? locus, were studied in relation to white matter lesion (WML), total brain, and hippocampal volumes in the Rotterdam Study I (RS-I, n=454). Associations that remained significant after multiple testing correction were subsequently studied in an independent population for replication (RS-II, n=607). Results: No associations with total brain or hippocampal volumes were detected. A haplotype block in REV-ERB? was associated with WML volumes in RS-I. Absence of this haplotype was associated with larger WML volumes in women (0.38%±0.18% [?±SE], p=0.007), but not in men (0.04%±0.11%, p=0.24), which was replicated in RS-II (women: 0.15%±0.05%, p=0.04; men: 0.05%±0.07%, p=0.80). Meta-analysis of the two populations showed that women lacking this haplotype have a 1.9 times larger WML volume (p=0.001). Conclusion: Our results suggest a role for REV-ERB? in the pathogenesis of WMLs.IST/Imaging Science and TechnologyApplied Science
Dataset - What enabled the forest transition? A socio-ecological counterfactual assessment for Austria, 1830-1910
No full textThis excel file contains data on forest change, food and energy provision, as well as greenhouse gas emissions from agriculture, forestry and energy use in Austria 1830-1910, and assessments of five counterfactual scenarios in the absence of specific forest relief processes. The data were used to create figures 1a and b, 2a, b, c, and d, 3a, b, c, and d, and 4a and b in the manuscript "What enabled the forest transition? A socio-ecological counterfactual assessment for Austria, 1830-1910" submitted to Global Biogeochemical Cycles in July 2020 by Simone Gingrich, Christian Lauk, Fridolin Krausmann, Karl-Heinz Erb, Julia Le Noë.
Dr. Simone Gingrich
Institute of Social Ecology (SEC)
Department of Economics and Social Sciences (WiSo)
University of Natural Resources & Life Sciences, Vienna (BOKU)
Post: Schottenfeldgasse 29, 1070 Vienna, Austria
Fon: +43 1 47654-73724
Web: http://www.wiso.boku.ac.at/wiso/sec
Light Exposure, Physical Activity, and Indigeneity Modulate Seasonal Variation in NR1D1 (REV-ERBα) Expression
No full textNuclear receptor subfamily 1 group D member 1 (NR1D1 or REV-ERBα) is a crucial element of the circadian clock’s transcriptional and translational feedback loop. Understanding its expression in humans is critical for elucidating its role in circadian rhythms and metabolic processes, and in finding potential links to various pathologies. In a longitudinal survey, we examined REV-ERBα expression at 08:00 using a real-time polymerase chain reaction (qRT-PCR) in blood mononuclear cells from Arctic native and non-native residents during equinoxes and solstices. REV-ERBα expression exhibited a pronounced seasonality, peaking at the summer solstice, and reaching a nadir at the winter solstice in both natives and non-natives, with a relatively higher summer peak in natives. After adjusting for age, sex, and body mass index, the amount and timing of light exposure, the amount of physical activity, and indigeneity emerged as significant predictors of REV-ERBα expression
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