151 research outputs found
Heme oxygenase-1 and nitric oxide in the vasculature: in vivo balloon injury and in vitro VSMC studies in rats
No full textModelling of microelectronic processes and materials
No full textOrganic electronics promises the creation of electronic components on flexible materials at low temperatures, by fast techniques and more environmentally friendly processes. The research followed two directions. The first part focused on the manufacturing technique nanoimprint lithography (NIL). A comprehensive review was undertaken and process capabilities were compared for trends. It was seen that small feature sizes (< 50 nm) have not been replicated over areas greater than 4 mm2, while aspect ratios greater than 10 have not been achieved. A questionnaire addressing market opportunities suggested NIL is likely to compete for the production of devices that currently use electron beam lithography and laser writing processes that are seeking to change their business strategy from a differentiation base to a cost reduction. NIL must also prove to customers that it is an economical investment. However, improvements in stamp creation, analysis techniques and overlay alignment need to be addressed for a larger share of the microfabrication market. It was apparent that physical limits exist to which imprints can be produced and an analytical model could predict these. A model was created to describe the de-embossing step and to explore how the various material properties and process variables interact. It showed a very strong dependence on the achievable aspect ratio on the pattern area ratio and the interfacial shear stress; that de-embossing using fluorinated coatings and current standard polymers is unlikely to fail for post radii on the order of 100 nm due to adhesion and that large area ratios and aspect ratios are more easily achieved by maintaining the polymer/stamp Young’s moduli ratio (RE) in the range 0.003 to 5.The second part of the research looked at the formation of crescent singularities in thin sheet materials, which affects the production of polymer electronic based devices produced by the sponsoring company. The author compared an analytical model by Cerda and Mahadevan for the formation of developable cones (d-cones) to a finite element (FE) model and showed that explicit elements could mimic the formation of a d-cone. Different elements were analysed for their suitability and the Belytschko-Lin-Tsay (BT) element was chosen based on its speed, robustness and similarity to the analytical results. An adapted three-point bend test set-up was conceived that would enable specific attributes to be independently varied, to understand their effect on d-cone formation in thin sheets. Digital image correlation (DIC) was used to calculate the displacements and strains. The same set-up was modelled using an FE model with the chosen BT element. The DIC results showed a variation in strain with plunger displacement before the visual appearance of a developable cone and that it occurred between 0.1 and 0.4 % in-plane strain. The FE data showed a similar trend to the DIC results, showing a change in strain once a d-cone began to form. Improvements and suggestions were then made advising how to make the DIC and FE models more accurate
Code stylometry vs formatting and minification
No full textThe automatic identification of code authors based on their programming styles- known as authorship attribution or code stylometry-has become possible in recent years thanks to improvements in machine learning-based techniques for author recognition. Once feasible at scale, code stylometry can be used for well-intended or malevolent activities, including: identifying the most expert coworker on a piece of code (if authorship information goes missing); fingerprinting open source developers to pitch them unsolicited job offers; de-anonymizing developers of illegal software to pursue them. Depending on their respective goals, stakeholders have an interest in making code stylometry either more or less effective. To inform these decisions we investigate how the accuracy of code stylometry is impacted by two common software development activities: code formatting and code minification. We perform code stylometry on Python code from the Google Code Jam dataset (59 authors) using a code2vec-based author classifier on concrete syntax tree (CST) representations of input source files. We conduct the experiment using both CSTs and ASTs (abstract syntax trees). We compare the respective classification accuracies on: (1) the original dataset, (2) the dataset formatted with Black, and (3) the dataset minified with Python Minifier. Our results show that: (1) CST-based stylometry performs better than AST-based (51.00%-*68%), (2) code formatting makes a significant dent (15%) in code stylometry accuracy (68%-*53%), with minification subtracting a further 3% (68%-*50%). While the accuracy reduction is significant for both code formatting and minification, neither is enough to make developers non-recognizable via code stylometry
A 3. sz. tanú nyilatkozata : Válasz Balla Zoltánnak a Képzeletbeli keresetlevél a bírósághoz című publikációjára
No full textMore than half a decade ago, the Specialised Lexicon of Police Science (Rendészettudományi szaklexikon) was published, and Zoltán Balla reflected on it in a unique way, in the form of an imaginary claim. His study attempted to provide a historical background to the production of the Lexicon. Anyone who lives in the world of science and books knows that a manuscript sent to a publisher nowadays may already be obsolete when printed. The author therefore agrees with the idea of reviewing the entries of the Lexicon and publishing a revised or a completely new version
Forensic Dental Identification: Practice in Indian Context Compared to Western Countries
No full textToday, in most of the countries forensic dental identification is considered as one of the most accurate and reliable method of identification of human remains. This application of forensic dentistry has proven successful in both single identification cases as well as in multiple fatality incidents such as world trade center disaster in 2001, the Asian tsunami in December 2004 etc. Comparative dental identification is one of the primary means of identification along with DNA and fingerprint analysis and also the most common method of identification of human remains. Identification of human remains from dental records is mandated by the law in some countries. India is one of the most disaster-prone countries of the world. It has had some of the world′s most severe droughts, famines, earthquakes, road accidents, and rail accidents. In this paper, few multiple fatality incidents that took place over the last decade in India are reported. A brief analysis of all the reported cases and difficulties encountered during identification were discussed. The purpose of this paper is to discuss some of the issues involved in body identifications following disasters in India. The author also discussed to what extent Indian government is successful in utilizing the expertise of a forensic dentist in body identifications and also compared the present practice of forensic dental identification in India to Western countries. The goal is to cite situations and to bring issues into better focus, and hence that the identification procedures can be refined and changes can be made as necessary
PARADOXICAL ESSENCE OF THE STORY IN BALLA´S FICTIONS
No full textThis study looks at fiction techniques and their semantic implications in the texts of a Slovak writer Balla. The author explains the paradoxical essence of the story in Balla’s works by means of the “event‘s” nature being different from that of the subject matter’s theme, going beyond the borderline separating the two distinctive semantic fields. Balla’s texts demonstrate the impossibility of changing the protagonist’s negative situation. The essence of the thematised problem is by its nature close to a themeless text that contradicts the usual storyness directed towards dynamic interaction between the subject and its surroundings. The static nature of the theme demands innovations in the text-producing process, while this also determines the process substantially. As the author’s treatment of the theme does not allow for thematic detention, the stronger becomes the author’s focus on procedures that are able to disintegrate disproportional thematic facets beyond straightforward verbalisation as well. In the frame of fictional semantics, the purpose is served by contaminating the fictional world with elements overlapping the “real” dimension and exploiting the text’s metaphorical components. Besides the two mentioned procedures, the tendency towards a more developed fictional structure is manifested in Balla’s work. If the story represents a medium of potential extension in Slovak cultural context, “story” in Balla’s texts means obstructing extension and in this way also the impossibility to experience the “otherness” of existence in motion. As a result, the fiction provides minimal transitivity into “transtextual” cathartic space. The ground for aggravated communication is the subject encircled in the causality of causes and effects, with an absence of the slightest hints concerning a breakthrough in his state. Thus the way to ease off the accumulated tension does not open by the text itself; but contrary to it, it is necessary to step out of it
Macrophage and epithelial cell H-ferritin expression regulates renal inflammation
No full textInflammation culminating in fibrosis contributes to progressive kidney disease. Cross-talk between the tubular epithelium and interstitial cells regulates inflammation by a coordinated release of cytokines and chemokines. Here we studied the role of heme oxygenase-1 (HO-1) and the heavy subunit of ferritin (FtH) in macrophage polarization and renal inflammation. Deficiency in HO-1 was associated with increased FtH expression, accumulation of macrophages with a dysregulated polarization profile, and increased fibrosis following unilateral ureteral obstruction in mice: a model of renal inflammation and fibrosis. Macrophage polarization in vitro was predominantly dependent on FtH expression in isolated bone marrow-derived mouse monocytes. Using transgenic mice with conditional deletion of FtH in the proximal tubules (FtH(PT-/-)) or myeloid cells (FtH(LysM-/-)), we found that myeloid FtH deficiency did not affect polarization or accumulation of macrophages in the injured kidney compared with wild-type (FtH(+/+)) controls. However, tubular FtH deletion led to a marked increase in proinflammatory macrophages. Furthermore, injured kidneys from FtH(PT-/-) mice expressed significantly higher levels of inflammatory chemokines and fibrosis compared with kidneys from FtH(+/+) and FtH(LysM-/-) mice. Thus, there are differential effects of FtH in macrophages and epithelial cells, which underscore the critical role of FtH in tubular-macrophage cross-talk during kidney injury
- …
