10 research outputs found
Jotham Musinguzi Interview with Susan Rich on the PopPov Initiative
No full textAt the 2014 PopPov Conference in Nairobi, Kenya, Susan Rich, vice president of International Programs at the Population Reference Bureau, interviewed Jotham Musinguzi, regional director of the Partners in Population and Development Africa Regional Office. Having attended seven PopPov research meetings, Musinguzi shares his perspective on findings that have emerged from the PopPov initiative and the role of researchers in communicating their findings to policymakers. He specifically discusses the demographic dividend and emphasizes the importance of dialogue between researchers and policymakers, ideally when the research project is conceptualized
Building Responsive Communities to Maternal and Child Health–Multi Disciplinary Approach
No full textKeynote Address, Save The Mother Conference and Reunion Presentations, 2018.Keynote address of save the mothers reunion conference by Dr. Musinguzi Jotham is a Public Health Physician and an advocate for inclusion of reproductive health and HIV/AIDS on the international development agenda. Currently, he is the Director General of the National Population Council. He worked with PPDA as the Africa Regional Director. Dr. Musinguzi is a
Types and Effectiveness of Community-Based Cardiovascular Disease Preventive Interventions in Reducing Alcohol Consumption: A Systematic Review and Meta-Analysis
No full textCardiovascular disease (CVD) poses a global health challenge, with modifiable risk factors, notably alcohol consumption, impacting its onset and progression. This review synthesizes evidence on the types and effectiveness of community-based interventions (CBIs) aimed at reducing alcohol consumption for CVD prevention. Electronic databases were systematically searched until October 31, 2019, with updates until February 28, 2023. Given the heterogeneity in outcome measures, we narratively synthesized the effectiveness of CBIs, adhering to the synthesis without meta-analysis (SWiM) guidelines for transparent reporting. For selected homogenous studies, a random-effects meta-analysis was utilized to estimate the effects of CBIs on alcohol consumption. Twenty-two eligible studies were included, with 16 demonstrating that CBIs reduced alcohol consumption compared to controls. Meta-analysis findings revealed reductions in above moderate-level alcohol consumption (pooled odds ratio (OR)=0.50, 95% confidence interval (CI): 0.37, 0.68), number of alcohol drinks per week (standardized mean difference=-0.08, 95% CI:-0.14,-0.03), and increased odds of low-risk drinking (pooled OR=1.99, 95% CI: 1.04, 3.81) compared to the control groups. Multi-component interventions (particularly those combining health education, awareness, and promotion activities) and those interventions with a duration of 12 months or more were notably effective. The beneficial effects of CBIs focusing on achieving a reduction in alcohol consumption showed promising outcomes. Implementing such interventions, especially multicomponent interventions, could play a significant role in mitigating the increasing burden of CVDs. Future studies should also consider employing standardized and validated tools to measure alcohol consumption outcomes to enhance the consistency and comparability of findings.We would like to thank the European Commission Horizon 2020 Research and Innovation for funding this work. We are also grateful to Deborah Jael Herrera for her valuable comments and contributions, including data visualization and proofreading of this manuscript. The first author (Neamin M. Berhe) and the second author (Hamid Y. Hassen) contributed equally to the work and should be considered co-first authors, while the last two authors (Hilde Bastiaens and Steven Abrams) should be considered co-senior authors
The Virgin HIV Puzzle: Can misreporting account for the high proportion of HIV cases in self-reported virgins?
No full textThe Demographic and Health Surveys from Lesotho, Zimbabwe, and Malawi reveal that a significant proportion of HIV infections in adolescent women occurred in women who claim to be virgin. Two possible conclusions arise from this observation: adolescent women misreport sexual status or non-sexual risk is more relevant than previously asserted. This paper uses a nonparametric model to estimate the proportion of HIV infections associated with sexual activity under different assumptions on data accuracy. It shows that there is an inverse relation between data accuracy and importance of sexual HIV transmission. If all adolescent women in the considered sub-sample correctly report sexual activity, 70% of HIV infections cannot be attributed to sexual HIV transmission. The model predicts that more than 95% of HIV infections are due to sexual HIV infections, if a substantial proportion of self-reported virgins (between 40 and 90%) misreport sexual status. --adolescent,HIV,misreporting,nonparametric modelling,sexual transmission
Multicomponent strategy with decentralised molecular testing for tuberculosis in Uganda: a cost and cost-effectiveness analysis
No full textBACKGROUND: Decentralised molecular testing for tuberculosis could reduce missed diagnoses and losses to follow-up in high-burden settings. The aim of this study was to evaluate the cost and cost-effectiveness of the Xpert Performance Evaluation for Linkage to Tuberculosis Care (XPEL-TB) study strategy, a multicomponent strategy including decentralised molecular testing for tuberculosis, in Uganda. METHODS: We conducted a costing and cost-effectiveness analysis nested in a pragmatic cluster-randomised trial of onsite (decentralised) versus hub-and-spoke (centralised) testing for tuberculosis with Xpert MTB/RIF Ultra (Xpert) in 20 community health centres in Uganda. We collected empirical data on the cost of the XPEL-TB strategy (decentralised Xpert testing, workflow redesign, and performance feedback) and routine tuberculosis testing (onsite smear microscopy with specimen transport for centralised Xpert testing) from the health system perspective. Time-and-motion studies were performed to estimate activity-based service costs. Cost-effectiveness was assessed as the incremental cost (2019 US20·46, range 18·20, range 20·28 (range 9·59 (range 1332 (95% uncertainty range 687 ($501–1207) per incremental patient initiating tuberculosis treatment within 14 days. Cost-effectiveness was reduced in sites performing fewer than 150–250 tests annually. INTERPRETATION: The XPEL-TB strategy facilitated higher rates of Xpert testing for tuberculosis at a similar per-test cost and modest incremental cost per tuberculosis diagnosis and treatment initiation. Decentralised Xpert testing, with appropriate implementation supports, should be scaled up to clinics with sufficient testing volume to support a single-module device. FUNDING: The National Heart, Lung, and Blood Institute
Ignorance in the time of AIDS: what we do, and do not know about the ABC message in Uganda
No full textThe reduction of the HIV prevalence rate in Uganda during the early 1990s is often attributed to the introduction of an ABC policy. The Ugandan government is thought to have maintained a consistent message that suggested behaviour change in response to the HIV epidemic - encouraging citizens to Abstain, Be faithful, and/or use Condoms. It is thought that such a policy provides individuals with behavioural 'options', allowing them to choose a manner of protecting themselves against HIV infection. Although often used as an example of a successful social policy, many questions regarding the case are still unanswered. This dissertation establishes what is and is not known about the decline in prevalence in Uganda, as well as the role played by the ABC policy in that decline. The dissertation takes the form of a literature survey using key terms relating to the case. The ABC concept and the issues relevant to its implementation are initially discussed on an abstract level. The dissertation then turns to the implementation of the ABC policy in Uganda and the alleged success thereof. Three key topics are discussed in relation to the case: 1) the available statistical evidence pertaining to HIV/AIDS rates, 2) the available statistical evidence of behaviour change in Uganda, and 3) the national policy employed by the Ugandan government during the past three decades. The ideological debate surrounding the current Ugandan policy is also discussed. From the analysis of the available literature on the ABC policy and the Ugandan case, it becomes evident that certain things are known about the topic while others are not. The literature shows that a decline in prevalence did indeed take place, but that the extent and timing of this decline are unclear. The literature also shows that prevention messages in the country did suggest a change in behaviour in response to the threat of HIV, but that the content of these messages was not consistent on a national level. 6 Most importantly, the literature does not support a clear link between the implementation of an ABC policy and behaviour change in Uganda, nor does it clearly support a link between an ABC policy and a decline in HIV prevalence. Further research on the effectiveness and potential negative impact of the ABC concept is necessary before it is widely implemented in other countries
Exploring associations between adolescent sexual and reproductive health stigma and HIV testing awareness and uptake among urban refugee and displaced youth in Kampala, Uganda
No full text© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://
creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any
medium, provided the original work is properly cited.Uganda, hosting over 1.3 million refugees, is a salient context for exploring HIV testing with urban refugee and displaced youth. We examined associations between stigma (HIV-related and adolescent sexual and reproductive health [SRH]-related) and HIV testing services awareness and HIV testing uptake among urban refugee and displaced youth in Kampala, Uganda. We implemented a cross-sectional survey with refugee and displaced adolescent girls and young women (AGYW) and adolescent boys and young men (ABYM) aged 16-24. We conducted exploratory and confirmatory factor analysis of an adolescent SRH stigma scale and identified a two-factor structure ("Sexual activity & pregnancy stigma","Modern family planning & abortion stigma"). We conducted multivariable logistic regression analysis to determine the adjusted risk ratio for HIV testing services awareness and testing uptake. Among participants (n=445; mean age=19.59, SD=2.60; AGYW: n=333; 74.7%), two-thirds were aware of HIV testing services in their community and over half (56.0%) had received a lifetime HIV test. In adjusted multivariable regression analysis findings with AGYW: (a) higher sexual activity & pregnancy stigma and modern family planning & abortion stigma were associated with reduced odds of HIV testing services awareness, and (b) modern family planning & abortion stigma was associated with reduced lifetime HIV testing odds. Stigma was not associated with HIV testing awareness/uptake among ABYM. HIV testing services awareness among AGYW was lower than among ABYM, yet AGYW were more likely to have been tested and to experience adolescent SRH stigma as a testing barrier. Addressing adolescent SRH stigma may optimise AGYW's HIV testing
UvA-DARE (Digital Academic Repository) Traditional birth attendants (TBAs) as potential agents in promoting male involvement in maternity preparedness: insights from a rural community in Uganda
No full textTraditional birth attendants (TBAs) as potential agents in promoting male involvement in maternity preparedness Insights from a rural community in Uganda General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Download date: 01 Jul 2019 R E S E A R C H Open Access Traditional birth attendants (TBAs) as potential agents in promoting male involvement in maternity preparedness: insights from a rural community in Uganda Abstract Background: Since the 1994 International Conference on Population and Development, male involvement in reproductive health issues has been advocated as a means to improve maternal and child health outcomes, but to date, health providers have failed to achieve successful male involvement in pregnancy care especially in rural and remote areas where majority of the underserved populations live. In an effort to enhance community participation in maternity care, TBAs were trained and equipped to ensure better care and quick referral. In 1997, after the advent of the World Health Organization's Safe Motherhood initiative, the enthusiasm turned away from traditional birth attendants (TBAs). However, in many developing countries, and especially in rural areas, TBAs continue to play a significant role. This study explored the interaction between men and TBAs in shaping maternal healthcare in a rural Ugandan context
The establishment of in vitro culture and drug screening systems for a newly isolated strain of Trypanosoma equiperdum
No full textapplication/pdfDourine is caused by Trypanosoma equiperdum via coitus with an infected horse. Although dourine is distributed in Equidae worldwide and is listed as an internationally important animal disease by the World Organization for Animal Health (OIE), no effective treatment strategies have been established. In addition, there are no reports on drug discovery, because no drug screening system exists for this parasite. A new T.?equiperdum strain was recently isolated from the genital organ of a stallion that showed typical symptoms of dourine. In the present study, we adapted T.?equiperdum IVM-t1 from soft agarose media to HMI-9 liquid media to develop a drug screening assay for T.?equiperdum. An intracellular ATP-based luciferase assay using CellTiter-Glo reagent and an intracellular dehydrogenase activity-based colorimetric assay using WTS-8 tetrazolium salt (CCK-8 reagent) were used in order to examine the trypanocidal effects of each compound. In addition, the IC50 values of 4 reference trypanocidal compounds (pentamidine, diminazene, suramin and melarsomine) were evaluated and compared using established assays. The IC50 values of these reference compounds corresponded well to previous studies involving other strains of T. equiperdum. The luciferase assay would be suitable for the mass screening of chemical libraries against T.?equiperdum because it allows for the simple and rapid-evaluation of the trypanocidal activities of test compounds, while a simple, inexpensive colorimetric assay will be applicable in developing countries for the evaluation of the drug sensitivity of epidemic trypanosome strains. c 2017 The Author
