307 research outputs found
Compact and low-power comb-locked transmitter based on ITLA tuneable lasers
No full textWe suggest and demonstrate a radically new approach to generate frequency-locked optical carriers. It provides for a low-power-consumption, self-starting and stable fibre comb operating across the entire C-band. We phase lock commercially-available Integrated-Tunable-Laser-Assembly (ITLA) lasers to the comb with arbitrary and fully tuneable spectral spacing
Pulmonary Vasculature Responsiveness to Phosphodiesterase-5A Inhibition in Heart Failure With Reduced Ejection Fraction: Possible Role of Plasma Potassium
No full textINTRODUCTION: Phosphodiesterase-5a inhibition (PDE5i) leads to favorable changes in pulmonary hemodynamic and cardiac output (CO) in patients with advanced heart failure (HF) and reduced ejection fraction (HFrEF). The hemodynamic response to PDE5i could be heterogeneous and the clinical variables associated with these changes are scarcely investigated. MATERIALS AND METHODS: Of 260 patients with advanced HFrEF referred for advanced therapies [cardiac transplant/left ventricular assist device (LVAD)], 55 had pulmonary hypertension (PH) and fulfilled the criteria for the PDE5i vasoreactivity test. Right heart catheterization (RHC) was performed as a part of clinical evaluation before and after 20-mg intravenous sildenafil. Absolute and relative changes in pulmonary vascular resistance (PVR) were evaluated to assess hemodynamic response to PDE5i. Clinical, biochemical, and hemodynamic factors associated with PVR changes were identified. RESULTS: Sildenafil administration reduced PVR (− 45.3%) and transpulmonary gradient (TPG; − 34.8%) and increased CO (+ 13.6%). Relative change analysis showed a negative moderate association between baseline plasma potassium and changes in PVR (r = − 0.48; p = 0.001) and TPG (r = − 0.43; p = 0.005) after PDE5i. Aldosterone concentration shows a direct moderate association with PVR changes after PDE5i. A significant moderate association was also demonstrated between CO improvement and the severity of mitral (r = 0.42; p = 0.002) and tricuspid (r = 0.39; p = 0.004) regurgitation. CONCLUSION: We identified plasma potassium, plasma aldosterone level, and atrioventricular valve regurgitations as potential cofounders of hemodynamic response to acute administration of PDE5i. Whether modulation of potassium levels could enhance pulmonary vasoreactivity in advanced HFrEF deserves further research
Comb-locked telecom-grade tunable laser using a low-cost FPGA-based lockbox
No full textWe frequency locked a commercial ITLA (integrable-tunable-laser-assembly) laser to an optical frequency comb with arbitrary carrier frequency within the telecom L band (1570-1625 nm). We achieved long-term (days) frequency stability below ±1.5 Hz
Kinstate intervention in ethnic conflicts : Albania and Turkey compared
No full textAlbania and Turkey did not act in overtly irredentist ways towards their ethnic brethren in neighboring states after the end of communism. Why, nonetheless, did Albania facilitate the increase of ethnic conflict in Kosovo and Macedonia, while Turkey did not, with respect to the Turks of Bulgaria? I argue that kin-states undergoing transition are more prone to intervene in external conflicts than states that are not, regardless of the salience of minority demands in the host-state. The transition weakens the institutions of the kin-state. Experiencing limited institutional constraints, self-seeking state officials create alliances with secessionist and autonomist movements across borders alongside their own ideological, clan-based and particularistic interests. Such alliances are often utilized to advance radical domestic agendas. Unlike in Albania's transition environment, in Turkey there were no emerging elites that could potentially form alliances and use external movements to legitimize their own domestic existence or claims
Prodloužení životnosti Dolu 1. Máj II (JLD Hodonín) přiřazením perspektivních zásob oblasti Mutěnice
No full textNávrh otvírky, přípravy a dobývání zásob II. sloje pod úrovní 11. patra včetně zásob dočasně vázaných na Dole Jindřich - RUD
No full textPrach - analýza jeho vlivu na životní prostředí, zdraví člověka a ekonomiku
No full textImport 04/07/201
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