14,388 research outputs found
Tim McConico and Emil Jones
No full textPhotograph shows Tim McConico and Emil Jones, residents of Peyton (later Board House), Blanco County, Texas, smoking cigars as they pose with bottle of whiskey
Interview with Tim Jones
No full textTim Jones, Personal Accounts Delivery Authority and NEST CEO (2007-2015) talks about the creation of a national pensions savings scheme (currently known as National Employment Savings Trust) and challenges facing the implementation
Visitation
No full text© the artist.Medium: etchingMedium: aquatintprintsSigned "Tim Jones" (l.r. ) udner image; dated "94" (l.r. ) under image"Visitation" [1996.2116.000.000], Jones, TimArtist and Role: Jones, Tim, ArtistExtent: sheet 38 x 56, Plate 25.7 x 35.
Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection.
Full text linkThe S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation. We investigated whether galectin-9/Tim-3 interactions contribute to the deletion and exhaustion of the antiviral T cell response in chronic hepatitis B virus infection (CHB). We found Tim-3 to be expressed on a higher percentage of CD4 and CD8 T cells from patients with CHB than healthy controls (p<0.0001) and to be enriched on activated T cells and those infiltrating the HBV-infected liver. Direct ex vivo examination of virus-specific CD8 T cells binding HLA-A2/peptide multimers revealed that Tim-3 was more highly upregulated on HBV-specific CD8 T cells than CMV-specific CD8 T cells or the global CD8 T cell population in patients with CHB (p<0.001) or than on HBV-specific CD8 after resolution of infection. T cells expressing Tim-3 had an impaired ability to produce IFN-γ and TNF-α upon recognition of HBV-peptides and were susceptible to galectin-9-triggered cell death in vitro. Galectin-9 was detectable at increased concentrations in the sera of patients with active CHB-related liver inflammation (p = 0.02) and was strongly expressed by Kupffer cells within the liver sinusoidal network. Tim-3 blockade resulted in enhanced expansion of HBV-specific CD8 T cells able to produce cytokines and mediate cytotoxicity in vitro. Blocking PD-1 in combination with Tim-3 enhanced the number of patients from whom functional antiviral responses could be recovered and/or the strength of responses, indicating that these co-inhibitory molecules play a non-redundant role in driving T cell exhaustion in CHB. Patients taking antivirals able to potently suppress HBV viraemia continued to express Tim-3 on their T cells and respond to Tim-3 blockade. In summary, both Tim-3 and galectin-9 are increased in CHB and may contribute to the inhibition and deletion of T cells as they infiltrate the HBV-infected liver
Woods with books
No full textMedium: wood engravingsigned and dated."Woods with books" [2013.0006.000.000], Jones, TimArtist and Role: Jones, Tim,Extent: blockExtent: shee
Do dolphins benefit from nonlinear mathematics when processing their sonar returns?
No full textAn interview with author Tim Leighton about the paper
Jones Junior High School eight grade students, Toledo, Ohio, 1965
No full textTerms associated with the photograph are: Jones Junior High School (Toledo, Ohio) | junior high schools | class portraits | 1965-1966 | eighth grade | students | Wilson, Harry | Valerious, John | Miller, James | Castro, Tom | Pariseau, Richard | Beary, Charles | Brewer, Ron | Hardison, Joyce | Weddle, Jerry | Lorenzen, Joan | Andros, Jennifer | Hartfield, Marjean | Harrison, Cassandra | Lawson, Sharon | Varnes, Hal | Smith, Tim | Saar, Larry | Rodriquez, David | Jones, Martha | Rawls, Ina | Dennis, Patty | Hughes, John | Smith, Terry | Gatter, Kathy | Urbina, Rosemary | Woodcock, Mike | Hrebic, Maryann | Mercer, Pam | Milem, Susette | teachers | Hermiller, Josep
Opportunities for linking young surveyors across professional surveying member organisations and FIG
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