1,722,011 research outputs found
The meaning of a republic
No full textJones, BT ORCiD: 0000-0002-4312-6995Australia is a country that has already embraced so many of
the finest features of republican philosophy. We believe in freedom,
equality, civic duty and the common good. Cicero claimed
that a republic is not just a group of people collected together in
any old way but a community of people committed to justice and the common good. When the Australian states federated in 1901, a
commitment was made to look beyond narrow individual interests
and to serve the common good. The hand of republicanism has
been on Australia's shoulder from colonial times to the present
day. As the renowned English republican Algernon Sidney put it,
the crew does not exist for the ship but the ship exists to serve the
people. Australia is destined to grow and prosper as a free and
independent republic, the champion of democracy and the home
of freedom
Response to heterogeneity of tests and platforms in economic evaluations: synthetic model adoption; derivatives of transferable practice
No full textWith reference to:Economic evaluation of genomic/genetic tests: a review and future directions: Published online by Cambridge University Press: 01 August 2022; Janet Bouttell, Robert Heggie, Karin Oien, Amy Romaniuk, Harper VanSteenhouse, Stephan von Delft and Neil HawkinsDear Colleagues,As noted by the authors at the time of publishing; attempts to resolve heterogeneity in economical evaluation continue to elude many parties. One proposition, drawn from carpentry, is put forth for the community for discussion.<br/
Systematic review of slicing analysis and prediction tools (SAPT) using SWiM (synthesis without meta-analysing) guidance
No full textBackground: Genetic variants affecting splicing play a fundamental role in disease pathogenicity.
Prediction of whether a genetic variant will affect splicing is difficult; many in silico tools exist which
require adjustment for accurate splice prediction. Best practice guidelines often do not exist and
different tools can provide confounding results. New high-throughput next-generation sequencing has
increased biological target capture of potential splice sites. Experimental validation is required to
characterise any variants in the splice region. The volume of this data, however, is vast; validation is slow,
costly and non-viable at scale. Computational tools offer a method to filter results to an actionable quota
suitable for experimental follow-up. Prediction of whether variation will affect splicing is challenging;
successful tools accelerate diagnosis and aid prioritization of variants of unknown significance with high
accuracy and reliability.
Objectives: To determine the effectiveness of eligible splicing analysis and prediction tools (SAPT) and,
where possible, rank them alongside providing best practice in their use whilst accounting for quality
during the appraisal of eligible tools.
Methods: This study systematically reviewed the literature ranging from 1 January 1980 to 21 October
2019 on SAPT. Statistical measures of specificity, sensitivity and/or accuracy were extracted to provide a
hierarchical ranking of tools efficacy and recommendations for best use to aid researchers and clinicians
to prioritise experimental follow-up. ‘synthesis without meta-analysis’ (SWiM) PRISMA-DTA guidance
shaped the review framework. Manual Pearl Gathering and PRISMA methods were followed for database
searching. The CHARMS checklist provided qualitative assessment rigour. Quantitative analysis of eligible
papers weighted SAPT in order preference. Idea Webbing and Triangulation were applied to complete
analysis.
Results: Across the subgroups core SAPT: MES, HSF, NNS and SSF-like had high-performance > 85%
accuracy. Combination tools emerged with superior performance with four exceeding > 95% accuracy:
SPiCE, HSF+SSF-like, HSF+SSF-like+MES, SPIDEX. Established SAPT: dbscSNA, PSSM and CADD alongside
SpliceAI reported high performance. Innovative study design within MMS and IntSplice reported
adequate performance 70% to 85% accuracy standalone.
Conclusions: Evidence was robust with minimal bias across the studies. Improvements are required in
the literature when reporting the delineation of thresholds. Common themes extracted: Effective tools
performed best on large curated datasets with separation of candidate predictors, determined in
statistical manner without human selection, using both positive and negative datasets. Highly targeted,
small window < 100 nucleotide or whole genome, excluding invariant positions, returned results with
established veracity. This study successfully developed a hierarchical list of SAPT effectiveness with
recommendations on optimal use
Atomic Layer Deposition, Nanoparticles, and Photochemistry
Full text linkThis research was supported by the Undergraduate Research Opportunities Program (UROP).Jones, Benjamin. (2014). Atomic Layer Deposition, Nanoparticles, and Photochemistry. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/163006
Land Grant Application- Jones, Benjamin (New York)
Full text linkLand grant application submitted to the Maine Land Office for Benjamin Jones for service in the Revolutionary War.https://digitalmaine.com/revolutionary_war_mass/1204/thumbnail.jp
Rekindling the Fire: The Republic and Australia's Future
No full textThe truth is that Australians' undivided allegiance to the British Crown died long ago. As Australia's head of state, the Queen embodies neither our present nor our future. Instead, she is a reminder of our distant past. Yet the monarchy remains long after its meaningful presence in Australian society has vanished. Ever since the defeat of the republic referendum in 1999, Australians have allowed the republic to languish on the backbenches of the political agenda. Lacking the imagination and political will to work through the democratic and political obstacles in its path, we have assigned the republic yet again to the sleeping and 'inevitable' position it has occupied for much of our history
Alien Registration- Jones, Benjamin E. (Portland, Cumberland County)
Full text linkhttps://digitalmaine.com/alien_docs/21520/thumbnail.jp
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