3,964 research outputs found
Dataset for Active Instantaneous-Phase Equalization and Amplitude Control in Pulse-Bursts in a Narrow-Linewidth Divided-Pulse Yb-Doped Fiber Amplification System
No full textDataset supports: Lin, H., Feng, Y., Price, J., Hawkins, T., Dong, L., & Nilsson, J. (2019). Active instantaneous-phase equalization and amplitude control in pulse-bursts in a narrow-linewidth divided-pulse Yb-doped fiber amplification system. In Advanced Solid State Lasers 2019 [ATh2A.2] OSA.</span
Dark matter-motivated searches for exotic fourth-generation mirror quarks in Tevatron and early LHC data
No full textWe determine the prospects for finding dark matter at the Tevatron and LHC through the production of exotic fourth-generation mirror quarks T ′ that decay through T′→tX, where X is dark matter. The resulting signal of tt̄+ET has not previously been considered in searches for fourth-generation quarks, but there are both general and specific dark matter motivations for this signal, and with slight modifications, this analysis applies to any scenario where invisible particles are produced in association with top quarks. Current direct and indirect bounds on such exotic quarks restrict their masses to be between 300 and 600 GeV, and the dark matter's mass may be anywhere below mT′. We simulate the signal and main backgrounds with MadGraph/MadEvent-Pythia-PGS4. For the Tevatron, we find that an integrated luminosity of 20fb-1 will allow 3σ discovery up to mT′=400GeV and 95% exclusion up to mT′=455GeV. For the 10 TeV LHC with 300pb-1, the discovery and exclusion sensitivities rise to 490 GeV and 600 GeV. These scenarios are therefore among the most promising for dark matter at colliders. Perhaps most interestingly, we find that dark matter models that can explain results from the DAMA, CDMS, and CoGeNT collaborations can be tested with high statistical significance using data already collected at the Tevatron and have extraordinarily promising implications for early runs of the LHC. © 2010 The American Physical Society
Retranslation hypotheses revisited : a case study of two English translations of Sanguo Yanyi - the first Chinese novel
No full textCITATION: Feng, L. 2014. Retranslation hypotheses revisited : a case study of two English translations of Sanguo Yanyi - the first Chinese novel. Stellenbosch Papers in Linguistics Plus, 43:69-86, doi:10.5842/43-0-209.The original publication is available at http://spilplus.journals.ac.zaThis article aims to review the theoretical assumptions of the phenomenon of retranslation, and
to test some of these assumptions by studying the data collected from three sample chapters
taken from the two complete English translations of Sanguo Yanyi – the first Chinese novel.
Firstly, the three suggested denotations of the concept of ‘retranslation’ are identified and
clarified. Secondly, the assumptions of retranslation are described, i.e. the necessity for
retranslation, motives for retranslation, and the relation between the first translation and the
retranslation of the same source text. Thirdly, the data from the sample chapters are analysed
to test these assumptions. The general macro-structural features and some of the microstructural
features of the two translations are studied and compared. Lastly, a conclusion from
the findings is drawn as the verification of the assumptions of the retranslation. The hypotheses
of retranslation are also briefly discussed.http://spilplus.journals.ac.za/pub/article/view/209Publisher's versio
Investigation of Lagrangian coherent structures in a wake-induced boundary layer transition
No full textThe evolution of coherent structures in a flat plate boundary layer transition induced by the cylinder wake is investigated using the particle image velocimetry (PIV) technique. The finite-time Lyapunov exponent (FTLE), which characterizes the amount of stretching about the flow trajectory, is used to extract the Lagrangian coherent structures. It is revealed that secondary vortex is induced by the cylinder wake vortices in the near wall region,which would evolve into hairpin vortex as it convects downstream. The subsequent evolvement of the hairpin vortex, characterized by the regeneration of offspring hairpin vortex upstream of it, leads to the appearance of the hairpin packet and the boundary layer finally reaches a turbulent state
Recombineering strategies for developing next generation BAC transgenic tools for optogenetics and beyond
No full textThe development and application of diverse BAC transgenic rodent lines has enabled rapid progress for precise molecular targeting of genetically-defined cell types in the mammalian central nervous system. These transgenic tools have played a central role in the optogenetic revolution in neuroscience. Indeed, an overwhelming proportion of studies in this field have made use of BAC transgenic Cre driver lines to achieve targeted expression of optogenetic probes in the brain. In addition, several BAC transgenic mouse lines have been established for direct cell-type specific expression of Channelrhodopsin-2 (ChR2). While the benefits of these new tools largely outweigh any accompanying challenges, many available BAC transgenic lines may suffer from confounds due in part to increased gene dosage of one or more “extra” genes contained within the large BAC DNA sequences. Here we discuss this under-appreciated issue and propose strategies for developing the next generation of BAC transgenic lines that are devoid of extra genes. Furthermore, we provide evidence that these strategies are simple, reproducible, and do not disrupt the intended cell-type specific transgene expression patterns for several distinct BAC clones. These strategies may be widely implemented for improved BAC transgenesis across diverse disciplines.Brain and Behavior Research Foundation (Young Investigator Award)National Institutes of Health (U.S.). Ruth L. Kirschstein National Research Service Award (F32-MH084460
Neurobiology of obsessive–compulsive disorder: insights into neural circuitry dysfunction through mouse genetics
No full textThe precise causal factors for obsessive–compulsive disorder (OCD) are not known, although, decades of research have honed in on the cortico-striatal-thalamo-cortical (CSTC) circuitry in the brain as a critical pathway involved in obsessions and the intimately linked compulsive–repetitive behaviors. Recent progress in human and mouse genetics have led to the identification of novel candidate susceptibility genes, which in turn have facilitated a more focused approach to unraveling the nature of circuitry dysfunction in OCD. The ability to perform invasive techniques in genetic animal models of OCD will be crucial for rapid advances in this field, and as such we review the most recent developments and highlight the importance of searching out common circuitry defects underlying compulsive–repetitive behaviors.National Institutes of Health (U.S.) (Grant NIMH R01MH081201)Hartwell FoundationSimons Foundation. Autism Research InitiativeStanley Center for Psychiatric ResearchBroad Institute of MIT and Harvard. SPARC ProgramBrain & Behavior Research Foundation (Young Investigator Award)National Institute of Mental Health (U.S.) (Ruth L. Kirschstein National Research Service Award F32MH084460
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First Long-Lived Particle Results and Commissioning of the ForwArd Search ExpeRiment
No full textThe ForwArd Search ExpeRiment (FASER) is collecting far-forward proton-proton collision data during the Large Hadron Collider's third running period (2022-2025). This thesis describes two of the first-proposed searches: for dark photon () and the gauge boson (). These searches are motivated by the proposed dark sector --- an extension to the Standard Model of particle physics that includes dark matter. These long-lived particles would mediate interactions between the Standard Model and the dark sector. Although larger experiments like ATLAS and CMS are well-suited to detect new, heavy particles, there may be low-mass particles produced in abundance along the axis of collision, in the far forward region. FASER, a 5m-long detector comprised of a magnetic spectrometer, scintillators, and calorimeters, is designed to study high-energy charged particles in this region. The experiment is installed in the repurposed SPS maintenance tunnel, TI12, 480m from the ATLAS interaction point and oriented along the line-of-sight. FASER's highly efficient veto system rejects all incoming muon events. Tracker readout is triggered by a timing scintillator or calorimeter signal. Dark sector models predict and from the decay of SM mesons, which are copiously produced in the far forward direction at ATLAS. They share a striking experimental signature, decaying into energetic electron-positron pairs. Event selection requires no entering (veto) signal, two good reconstructed tracks, and a calorimeter deposit of at least 500 GeV. The expected background for the search is events for 27 fb luminosity and is dominated by neutrino interactions with the detector materials. FASER collected its first year of data in 2022, with results first presented at the March 2023 Moriond conferences. No candidates were observed. FASER excluded new regions of parameter space for and at 90\% confidence level
Searches for Gauge-Mediated SUSY Breaking Topologies with the L3 Detector at LEP
No full textSearches for topologies predicted by gauge-mediated SUSY breaking models were performed using data collected with the L3 detector at LEP. All possible lifetimes of the next-to-lightest SUSY particle (NLSP), neutralino or scalar tau, were considered. No evidence for these new phenomena was found and limits on the production cross sections and sparticle masses were derived. A scan over the parameters of the minimal GMSB model was performed, leading to lower limits of 62.2 GeV, 11 TeV, and 0.07 eV on the NLSP mass, the mass scale parameter Λ, and the gravitino mass, respectively. The status of the LEP combined searches is also discussed
Development of transgenic animals for optogenetic manipulation of mammalian nervous system function: Progress and prospects for behavioral neuroscience
No full textHere we review the rapidly growing toolbox of transgenic mice and rats that exhibit functional expression of engineered opsins for neuronal activation and silencing with light. Collectively, these transgenic animals are enabling neuroscientists to access and manipulate the many diverse cell types in the mammalian nervous system in order to probe synaptic and circuitry connectivity, function, and dysfunction. The availability of transgenic lines affords important advantages such as stable and heritable transgene expression patterns across experimental cohorts. As such, the use of transgenic lines precludes the need for other costly and labor-intensive procedures to achieve functional transgene expression in each individual experimental animal. This represents an important consideration when large cohorts of experimental animals are desirable as in many common behavioral assays. We describe the diverse strategies that have been implemented for developing transgenic mouse and rat lines and highlight recent advances that have led to dramatic improvements in achieving functional transgene expression of engineered opsins. Furthermore, we discuss considerations and caveats associated with implementing recently developed transgenic lines for optogenetics-based experimentation. Lastly, we propose strategies that can be implemented to develop and refine the next generation of genetically modified animals for behaviorally-focused optogenetics-based applications.Poitras Center for Affective Disorders ResearchNational Institute of Mental Health (U.S.) (American Recovery and Reinvestment Act Grant RC1-MH088434)National Alliance for Research on Schizophrenia and Depression. The Brain and Behavior Research Foundation (Young Investigator Award)National Institutes of Health (U.S.) (Ruth L. Kirschstein National Research Service Award F32MH084460
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