351 research outputs found
Translation and response between Maurice Blanchot and Lydia Davis
No full textWhen an author translates a text by another writer, this translation is one form of a response to that text. Other responses may appear in their own writings that are more inflected with their authorial persona. Lydia Davis translated six books by Maurice Blanchot, including fiction and theoretical writings. Blanchot’s concept of the récit privileges non-conventional forms of narrative and it can be considered to have influenced Davis, a view shared in critical writing about Davis. However, responses to his fiction can also be found in Davis’s work. This article reads Lydia Davis’s story “Story” as a response to Maurice Blanchot’s récit, La Folie du jour, translated by Davis as “The Madness of the Day”. Both texts develop a narrative that questions the possibility of arriving at a single story: Blanchot’s narrator cannot tell the story of how he came to have glass ground into his eyes, while Davis’s narrator must try to understand a contradictory story told to her by her lover. However, Davis responds to Blanchot by reversing the perspective in the story: where Blanchot’s narrator must and cannot create a story that explains his situation in a judicial/medical context, Davis’s narrator is struggling to understand her lover’s story which does not explain the situation that they find themselves in. Davis’s narrator is therefore motivated by an emotional need to find an acceptable story that is absent from Blanchot’s narrator. This difference in motivation is central to the difference between Davis’s and Blanchot’s approach, and complicates any reading of his influence on her because she responds to his text in her own
Visual Depictions of Search Results: using glyphs and coordinated multiple-views
No full textJonathan Roberts, Nadia Boukhelifa, Peter Rodgers have developed a system that can visualize search-result data using glyphs and coordinated multiple-views. They stress a need for a web-search result visualization as the rank-ordered lists of search results allow the user view only a small proportion of the results in a single window. Some of the glyphs show the domain of the site of each webpage (with the addresses: .country, .com, .edu, .org, or .net mapped to triangle, circle, square, parallelogram, hexagon, plus-symbol, respectively), where the rank is allocated a color (with a brighter color representing a higher ranked entity) and the size of the page relates to the border-width of the glyph. Another glyph design is based on quartiles (with the use of color, placement, and concentric rings) and allowed to assign the quantities to the lower, median or upper quartile or represent the measure of external and internal links of a site placement
UTILIZING CHERNOFF FACES IN MODELING RESPONSES IN THE EVALUATION OF TRIMESTER SCHEME IMPLEMENTATION
No full textThis study uses Chernoff faces to model the responses of students, faculty, and administration staff of a teacher education institution in Manila, Philippines, to the implementation of an Outcomes-Based Teacher Education Curriculum (OBTEC) trimester scheme. Chernoff faces provide a valuable representation to model responses because people are used to studying and reacting to faces. This study used a quantitative research method by analyzing cross-sectional data from the study of the OBTEC trimester scheme. A total of 322 participants were selected through convenience sampling and given a 15-item survey in which possible responses ranged from 1 (strongly disagree) to 6 (strongly agree). The administrators were found to give a generally favorable rating (overall mean = 4.56 agree; overall SD = 0.45) to the OBTEC trimester scheme. The statements most highly rated by the administrators pertain to the success of OBTEC in integrating pedagogical content knowledge training with outcomes-based education, preparation of the students for the teaching profession, and consistency with the K to 12 curriculum. These responses are characterized by the structure of the face, the width of the mouth, and the height of the face, respectively. The most negative aspects of the OBTEC trimester scheme, according to the students, are characterized by hair height, nose width, and a hair style of thin hair that points downward. Chernoff faces were found to be a simple, yet powerful tool to model responses in the evaluation of the OBTEC trimester scheme
DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors
No full text Classical estrogen, progesterone, and androgen receptors (ERs, PRs, and ARs) localize outside the nucleus at the plasma membrane of target cells. From the membrane, the receptors signal to activate kinase cascades that are essential for the modulation of transcription and nongenomic functions in many target cells. ER, PR, and AR trafficking to the membrane requires receptor palmitoylation by palmitoylacyltransferase (PAT) protein(s). However, the identity of the steroid receptor PAT(s) is unknown. We identified the DHHC-7 and -21 proteins as conserved PATs for the sex steroid receptors. From DHHC-7 and -21 knockdown studies, the PATs are required for endogenous ER, PR, and AR palmitoylation, membrane trafficking, and rapid signal transduction in cancer cells. Thus the DHHC-7 and -21 proteins are novel targets to selectively inhibit membrane sex steroid receptor localization and function. </jats:p
Multiple sources of signal amplification within the B-cell Ras/MAPK pathway
No full textThe Ras-Map kinase (MAPK) cascade underlies functional decisions in a wide range of cell types and organisms. In B-cells, positive feedback-driven Ras activation is the proposed source of the digital (all or none) MAPK responses following antigen stimulation. However, an inability to measure endogenous Ras activity in living cells has hampered our ability to test this model directly. Here we leverage biosensors of endogenous Ras and ERK activity to revisit this question. We find that B-cell receptor (BCR) ligation drives switch-like Ras activation and that lower BCR signaling output is required for the maintenance versus the initiation of Ras activation. Surprisingly, digital ERK responses persist in the absence of positive feedback-mediated Ras activation, and digital ERK is observed at a threshold level of Ras activation. These data suggest an independent analogue-to-digital switch downstream of Ras activation and reveal that multiple sources of signal amplification exist within the Ras-ERK module of the BCR pathway
TRAF2 recruitment via T61 in CD30 drives NFκB activation and enhances hESC survival and proliferation.
No full textCD30 (TNFRSF8), a tumor necrosis factor receptor family protein, and CD30 variant (CD30v), a ligand-independent form encoding only the cytoplasmic signaling domain, are concurrently overexpressed in transformed human embryonic stem cells (hESCs) or hESCs cultured in the presence of ascorbate. CD30 and CD30v are believed to increase hESC survival and proliferation through NF kappa B activation, but how this occurs is largely unknown. Here we demonstrate that hESCs that endogenously express CD30v and hESCs that artificially overexpress CD30v exhibit increased ERK phosphorylation levels, activation of the canonical NF kappa B pathway, down-regulation of the noncanonical NF kappa B pathway, and reduced expression of the full-length CD30 protein. We further find that CD30v, surprisingly, resides predominantly in the nucleus of hESC. We demonstrate that alanine substitution of a single threonine residue at position 61 (T61) in CD30v abrogates CD30v-mediated NF kappa B activation, CD30v-mediated resistance to apoptosis, and CD30v-enhanced proliferation, as well as restores normal G2/M-checkpoint arrest upon H2O2 treatment while maintaining its unexpected subcellular distribution. Using an affinity purification strategy and LC-MS, we identified TRAF2 as the predominant protein that interacts with WT CD30v but not the T61A-mutant form in hESCs. The identification of Thr-61 as a critical residue for TRAF2 recruitment and canonical NF kappa B signaling by CD30v reveals the substantial contribution that this molecule makes to overall NF kappa B activity, cell cycle changes, and survival in hESCs
After bipolarity the vanishing threat, theories of cooperation, and the future of the Atlantic Alliance
No full textThe demise of the Soviet threat has compelled the United States and Europe to reassess how they deal with each other and with the rest of the world. For the past forty-five years, NATO has been the centerpiece of U.S.-European security relations, but some analysts now argue that the alliance can no longer survive. Should NATO states continue to rely on the NATO alliance for security? Several theories have been advanced to help answer this question. Nevertheless, After Bipolarity defends the argument that none of them - neorealism, neoliberal institutionalism, or cybernetic theory - is an entirely convincing account of past relations among NATO states and proposes a new theory based on disparate elements of these earlier theories. The author builds his case on twenty-one instances where alliance cooperation was sought, from the Suez crisis to Operation Desert Storm, representing a variety of issue areas: arms deployments, arms control, out-of-area operations, and alliance doctrine. Much of the data for the case studies comes from interviews with government and alliance officials and sheds considerable new light on certain key alliance decisions. After Bipolarity makes use of a variety of methods to test the key variables. Boolean algebra, in particular, is used to illuminate the author's theory, which contends that there is no unique set of necessary and sufficient conditions for cooperation but that there are alternate sets of conditions that may produce cooperative behavior. It is noteworthy that threat perception, a variable emphasized in widely accepted realist and neorealist theories, does not perform as well as other, less popular variables in explaining cooperation. Chernoff concludes that without a commonly perceived threat, continued transatlantic cooperation will be possible but will require a more diligent management of intra-alliance relations
How might a culture of appreciation be cultivated at JIBC?
No full textAn appreciative workplace culture has been demonstrated to increase the health of its employees which in turn increases the health of the organization by reducing absenteeism caused by sick leave, stress leave, and turnover (Chapman & White, 2011). Although limited, all previous literature demonstrated positive impacts for organizations that develop and sustain a culture of appreciation. By exploring appreciation within JIBC through employee dialogue, the opportunity existed to enhance the health and functioning of the organization.Not peer reviewedThis poster is related to Melanie Chernoff's Royal Roads University Masters Thesisstress; sick leave; appreciation; employee motivation; absenteeis
Faculty Opinions recommendation of Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation.
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