8,265 research outputs found
Multiple functions of LIM domain-binding CLIM/NLI/Ldb cofactors during zebrafish development
No full textThe crucial involvement of CLIM/NLI/Ldb cofactors for the exertion of the biological activity of LIM homeodomain transcription factors (LIM-HD) has been demonstrated. In this paper we show that CLIM cofactors are widely expressed during zebrafish development with high protein levels in specific neuronal cell types where LIM-HD proteins of the Isl class are synthesized. The overexpression of a dominant-negative CLIM molecule (DN-CLIM) that contains the LIM interaction domain (LID) during early developmental stages of zebrafish embryos results in an impairment of eye and midbrain-hindbrain boundary (MHB) development and disturbances in the formation of the anterior midline. On a cellular level we show that the outgrowth of peripheral but not central axons from Rohon Beard (RB) and trigeminal sensory neurons is inhibited by DN-CLIM overexpression. We demonstrate a further critical role of CLIM cofactors for axonal outgrowth of motor neurons. Additionally, DN-CLIM overexpression causes an increase of Isl-protein expression levels in specific neuronal cell types, likely due to a protection of the DN-CLIM/LIM-HD complex from proteasomal degradation. Our results demonstrate multiple roles of the CLIM cofactor family for the development of entire organs, axonal outgrowth of specific neurons and protein expression levels
Optimizing therapy in advanced stage Hodgkin Lymphoma
No full textThe treatment of Hodgkin Lymphoma has evolved continuously since the introduction of extended-field radiotherapy in the 1960s to involved-field then involved-node radiotherapy, multi-agent chemotherapy, combined chemo-radiotherapy, risk-adapted and response-adapted modulation, and most recently, introduction of antibody-drug conjugates and immune checkpoint-blocking antibodies. These changes have translated into progressively increasing cure rates, so that 10-year survival figures now exceed 80%, compared to less than 50% 40 years ago. The challenge now is how to improve upon success while maintaining, or if possible improving, the quality of life for survivors. Steering between under-treatment, with the risk of avoidable recurrences, and over-treatment, with the risk of unnecessary toxicity, remains complex since control of the lymphoma and the probability of survival are no longer closely linked. This requires trials with long follow-up and continuous re-appraisal of the interaction between the illness; the method used to define risk, and the type of treatment involved. One important factor in this is age: outcomes in older patients have not improved at the same rate as those in the population under 60, reflecting the need for different approaches. Recently, treatment has moved from being primarily risk-based, using baseline characteristics such as anatomical stage and severity of the illness, to a more dynamic approach which takes account of the response to therapy, using functional imaging to make an early appraisal, with the option to modulate subsequent treatment. The results of several trials indicate that this has advantages, but that a combination of risk- and response-adaptation is probably ideal
Supplemental Data for the Journal Article Entitled The mechanistic origins of heterogeneous void growth during ductile failure accepted for publication by Acta Materialia
No full text<p>This repository contains the Supplemental Data for the Journal Article Entitled The mechanistic origins of heterogeneous void growth during ductile failure accepted for publication by Acta Materialia.</p>
<p>Authors: M.W. Vaughan<sup>a</sup>, H. Lim<sup>a</sup>, B. Pham<sup>a</sup>, R. Seede<sup>a</sup>, A. T. Polonsky<sup> a</sup>, K. Johnson<sup> a</sup>, P. J. Noell<sup>a,*</sup></p>
<p>a: Sandia National Laboratories, Albuquerque, NM 87123</p>
<p>Each folder contains a ReadMe.txt describing the files and their organization within each folder. </p>
<p><br>Acknowledgements:<br><span>This work was supported by the Laboratory Directed Research and Development program at Sandia National Laboratories, a multimission laboratory managed and operated by National Technology and Engineering Solutions of Sandia LLC, a wholly owned subsidiary of Honeywell International Inc. for the U.S. Department of Energy’s National Nuclear Security Administration under contract DE-NA0003525. The views expressed in the article do not necessarily represent the views of the U.S. DOE or the United States Government. </span></p>
Yves-Heng Lim
No full textYves-Heng Lim est enseignant-chercheur au Département d’Etudes de Sécurité et de Criminologie de l’Université Macquarie, Sydney. Il est l’auteur de China’s Naval Power: An Offensive Realist Approach (Ashgate, 2014). Yves-Heng Lim is a lecturer at the Department of Security Studies and Criminology, Macquarie University. He is the author of China’s Naval Power: An Offensive Realist Approach (Ashgate, 2014)
Chemotherapy: advanced Hodgkin lymphoma - balancing toxicity and cure
No full textThe combination of doxorubicin, bleomycin, vincristine and dacarbazine (ABVD) has emerged as a standard of care in advanced-stage Hodgkin lymphoma over the past four decades. Clinicians treating patients with cancer frequently walk a tightrope where the requirements of efficacy have to be balanced against the morbidity caused by the treatment
Professional attachment report [with] Chio Lim & Associates.
No full textThis report serves as a summary of the professional attachment. Besides touching on author experiences working with Chio Lim & Associates (CLA), it wil also touch on other issues before, during and after the program
Lim-inf convergence and its compactness
No full textAbstract- We describe the Mizar formalization of the proof of compactness of lim-inf convergence given in [W33] according to [CCL]. Lim-inf convergence formalized in [W28] is a Moore-Smith convergence investigated in [Y6] and involves the concept of nets. The proof is based on the equivalence of two approaches to convergence in topological spaces: filter convergence and Moore-Smith (net) convergence. The equivalence is worked out in [Y19] and different characterizations of compactness are also given there. These efforts are a continuation of the international project of formalizing the theory of continuous lattices headed by the first author
Strange forces
No full textRecorded by ELISION who were Ensemble-in-residence with CeReNeM during 2009-10. Strange forces (music by Aaron Cassidy, Richard Barrett, Evan Johnson, Klaus K. Hübler, Liza Lim and Timothy McCormack) were launched on 23 November 2010 at ELISION’s concert during the Huddersfield Contemporary Music Festival.
The CD was recorded in partnership with the German radio station, Radio Bremen and feature works premiered during hcmf 2009 and ELISION’s Kings Place concert series in London. Musicologist Tim Rutherford-Johnson has written the liner notes for both discs
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