6,213 research outputs found
Anne Johnson Hunt portrait, undated
No full textColor photograph of Anne Johnson Hunt. The captions on the reverse of the image read, "Anne Johnson Hunt" and "Local - 1 col w/s." The stamp on the reverse of the image reads, "NEWS BUREAU; U-T-C; CHATTANOOGA 37403.
Anne Johnson Hunt portrait, undated
No full textColor photograph of Anne Johnson Hunt. The captions on the reverse of the image read, "Anne Johnson Hunt" and "Local - 1 col w/s." The stamp on the reverse of the image reads, "NEWS BUREAU; U-T-C; CHATTANOOGA 37403.
'The cracked mirror': Anne Sexton's poetics of self-representation
No full textThis thesis re-evaluates the work of the poet Anne Sexton (1928-1974), concentrating, in particular, on the indeterminacies, contradictions and aporia which it finds to be characteristic of her ostensibly frank and self-revelatory writing. The study is based on a close textual
analysis of Sexton's writing, is informed by oststructuralist theories, and is sustained by an
examination and discussion of archive collections of her previously unpublished papers. In seeking an understanding of Sexton's poetics, the thesis identifies and interrogates the strategies of denial and obfuscation apparent in her own explication of her work - principally, by scrutiny of the unpublished, and previously unresearched, drafts of a series of lectures
which she delivered in 1972. Chapters One and Two consider the origins of `confessional' or - Sexton's preferred term - 'personal' poetry and reassess her place within contemporary poetry. They suggest that
Sexton's writing is engaged in a process of negotiation and contestation, both with the boundaries and expectations of confessionalism, and with the strictures of T. S. Eliot's theory of `impersonality'. In support of these arguments, Chapter Two offer a reading of Sexton's
little-known poem, `Hurry Up Please It's Time', alongside its intertext, Eliot's The Waste Land. Chapter Three reassesses received views of the supposedly beneficial interrelationship between confessional speaker and reader. It examines Sexton's appropriation of dramatic
masks and personae and her use of metaphors of striptease and prostitution, and suggests that these are employed simultaneously to appease and to repel an intrusive audience. Similarly, Chapters Four and Five trace Sexton's problematisation of two previously-accepted tenets of confessional poetry: its status as autobiography and its truthfulness, drawing attention to the techniques employed in order to give the impression of both. Chapter Six considers Sexton's
problematic engagement with a language which is not malleable, transparent, and referential but, rather, is experienced as uncooperative and occlusive. Finally, the thesis recuperates Sexton from the common charge of narcissism, arguing that it is the writing, rather than the poet, which is self-reflexive and self-conscious. In this respect, it concludes that her work - perhaps unexpectedly - anticipates many of the tendencies of postmodernist writing
Concurrent validity of the differential ability scales and the Woodcock-Johnson-III Tests of Cognitive Abilities for young children
No full textPlan BValidation studies assess how comparable intelligence instruments are with regard to the cognitive abilities they assess. Results derived from such studies are used to make inferences as to how instruments are similar and different regarding the abilities that they are designed to measure. This paper is a review and critical analysis of literature related to the validity of two intellectual assessment instruments often used with young children, the Differential Ability Scales (DAS) and the Woodcock-Johnson-Third Edition Tests of Cognitive Abilities (WJ-III COG). Topics covered in the literature review include issues regarding the assessment of young children, the importance of test validity, and the theoretical foundations of each instrument, as well as their practical use with young children. The purpose of this paper is to propose a study examining the concurrent validity of the DAS and WJ-III COG when used with a sample of young children receiving special education services for speech and language delays
Translations of the Self: A.E. Housman and Anne Carson, Between Scholarship and Creativity
No full textIn my PhD thesis I have explored some aspects of the interface between classical scholarship and creativity, through the work and careers of two scholar-poets, Anne Carson (1950 - ) and A.E. Housman (1859-1936). I have shown how, within their social and cultural contexts, they attempted to craft their careers by using both genres of their work to help them construct carefully-crafted public profiles, and how these self-translations within their careers relate to received versions of their work by different readerships. By connecting explorations of their social and cultural contexts with their biographies and with close readings of their scholarly and creative work, I explore the shifting relationship between creative and scholarly ‘cultural fields’, as well as the recent social, cultural, and institutional changes which have turned these fields from ‘homogeneous poles’ to ‘heterogeneous poles’ (to use Pierre Bourdieu’s terms). I examine the surprising similarities in the unusual personalities of Carson and Housman, who both have, or had, a tendency to use their reputations for independence and reclusiveness to help them navigate around important issues and conflicts which could have threatened their success. I show how they have constructed versions of themselves, both within and beyond their writings, which have enabled them to make grand assertions of the self in the teeth of social and cultural necessities
Depression and Gender: The Expression and Experience of Melancholy in the Eighteenth Century
No full textThis thesis investigates the life and work of six eighteenth-century writers, two male and four female. It explores their experience of depression through their letters and other autobiographical material, and examines the ways in which they represent melancholy in their poetry and prose. The subject of Chapter Two is Thomas Gray, whose real life persona as the lonely intellectual is also identifiable in his poetry. The Scottish poet Robert Fergusson is studied in Chapter Three. Fergusson’s lively and vigorous mind was shattered in the months leading up to his death, during which time some of his writing became darkly nihilistic. Chapter Four looks at Anne Finch, Countess of Winchilsea, a lifelong depressive who often wrote about her feelings of despair in her poetry. Chapter Five explores Lady Mary Wortley Montagu. She was a courageous and controversial figure, but despite her resilience, on occasion in her letters she reveals her vulnerability and susceptibility to low spirits, a mood which is sometimes expressed in her creative writing. Sarah Scott, whose life and work have not yet been considered in relation to the subject of melancholy, is examined in Chapter Six. Her novel includes several low-spirited and depressed female characters who are continually seeking asylum from a hostile world. Chapter Seven analyses Charlotte Smith, a mother of twelve children whose unhappy marriage ended in separation. Smith wrote extensively about her depression in her letters, prefaces, poetry and novels.
This study shows that the women in particular use their writing on melancholy and depression to express their discontent with the confined way in which they are often expected to live out their lives
REVIEW OF CAR T-CELL THERAPY AND ITS USE IN THE TREATMENT OF SOLID TUMOR CANCERS
No full textThesis (M.S.)--Michigan State University. Basic Medical Science - Master of Science, 2024CAR T-cell immunotherapy has been rapidly developing over the last 2 decades. The expanding list of cancer targets provides more and more treatment opportunities. The purpose of this research review is to discuss CAR T-cell immunotherapy, to compare and contrast this therapy to the gold standards of cancer treatment, and to examine its developing use for solid tumor cancers.Targeted immunotherapies, such as CAR T-cells, are a more recent addition to the treatment options for solid tumor cancers. While initially developed for use with hematologic malignancies, CAR T-cells have now successfully been used to treat a variety of solid tumor cancers (National Cancer Institute, 2022). The use of CAR T-cell immunotherapy for solid tumors is promising, with about 30 antigens being targeted in ongoing clinical trials (Newick et al., 2016). The current opportunities for treatment include lung cancer, kidney cancer, bone cancer, breast cancer, prostate cancer, and glioblastoma (Guzman et al., 2023). The use of CAR T-cell immunotherapy for solid tumor cancers faces obstacles such as cell trafficking restrictions into the tumor site, a hostile tumor microenvironment, antigen heterogeneity, CAR T-cell exhaustion, and potential severe toxicities that can hamper clinical efficacy. With new and ongoing research of potential antigen targets and the development of counter strategies, such as combination therapies and additional modification of the CAR T-cells, being tested, there still significant potential therapeutic efficacy for the use of CAR T-cell immunotherapy for solid tumor cancers.Description based on online resource. Title from PDF t.p. (Michigan State University Fedora Repository, viewed ).Includes bibliographical references
The fables of pity: Rousseau, Mandeville and the animal-fable
No full textCopyright @ 2012 Edinburgh University PressPrompted by Derrida’s work on the animal-fable in eighteenth-century debates about political power, this article examines the role played by the fiction of the animal in thinking of pity as either a natural virtue (in Rousseau’s Second Discourse) or as a natural passion (in Mandeville’s The Fable of the Bees). The war of fables between Rousseau and Mandeville – and their hostile reception by Samuel Johnson and Adam Smith – reinforce that the animal-fable illustrates not so much the proper of man as the possibilities and limitations of a moral philosophy that is unable to address the political realities of the state
Computation and application of the lattice Green function to dislocations in metals, intermetallics, and semiconductors
No full textDislocations are fundamental crystallographic defects that play key roles in determining material properties. The first step to understanding dislocations and being able to model them accurately is knowing their geometry. While the far-field geometry of a dislocation can be well described by anisotropic continuum elasticity theory, the elastic solution diverges close to the dislocation core. Methods such as density functional theory (DFT) are needed to accurately determine the geometry in the dislocation core; however, the long-range strain field of a dislocation is incompatible with periodic boundary conditions, making it challenging to perform DFT calculations of isolated dislocations. The flexible boundary condition (FBC) approach captures the correct long-range response of the dislocation by coupling the dislocation core to an infinite harmonic bulk through the lattice Green function (LGF). To improve the accuracy and efficiency of the FBC approach, we develop a numerical method to compute the LGF specifically for a dislocation geometry by directly accounting for its topology. This is in contrast to previous methods, where the LGF was computed for the perfect bulk as an approximation for the dislocation. The dislocation LGF computed using our method describes the response around the dislocation more accurately than the perfect bulk LGF, and relaxes dislocation core geometries efficiently when used within the FBC approach. We apply this method to compute the LGF for screw, edge, and mixed dislocations in metals, intermetallics, and semiconductors, and use them within the FBC approach coupled with DFT to accurately determine the equilibrium dislocation core structures. First, we compute the core structures of five different dislocations in BCC iron -- screw, mixed, edge, edge, and edge dislocations, and find a dependence of the local magnetic moment on the local strain. Next, we compute the relaxed core structures of the Ni screw dislocation and the \NiAl\ superdislocation, demonstrating the first fully atomistic DFT calculation of an extended dislocation core structure in an intermetallic. Finally, we compute single-period, double-period, and quadruple-period dislocation core reconstructions of the 60 Cd-core dislocation in CdTe. Through this work, we demonstrate the generality and versatility of our method to compute LGF and relax dislocation core structures in a wide range of technologically important material systems.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2020-08-01The student, Anne Marie Tan, accepted the attached license on 2018-05-25 at 14:03.The student, Anne Marie Tan, submitted this Dissertation for approval on 2018-05-25 at 14:11.This Dissertation was approved for publication on 2018-05-25 at 15:57.DSpace SAF Submission Ingestion Package generated from Vireo submission #12595 on 2018-09-27 at 11:15:49Made available in DSpace on 2018-09-27T16:28:03Z (GMT). No. of bitstreams: 2
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Moving between worlds : gender, class, politics, sexuality and women's networks in the diaries of Anne Lister of Shibden Hall, Halifax, Yorkshire, 1830-1840.
No full textSIGLEAvailable from British Library Document Supply Centre- DSC:DXN003174 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
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