631 research outputs found
The glad girl : idyl for piano, popular edition ; lovingly ascribed to Patricia Collinge
No full textGift of Dr. Mary Jane Esplen.Piano [instrumentation]C [key]Tempo di gavotte [tempo]Popular song [form/genre]Decorative ; Patricia Collinge (photograph) [illustration]Starmer [engraver]Publisher's advertisement on inside front and back cover [note
Patricia Collinge and Ruth Hussey in TENDER COMRADE, 1943
No full textPatricia Collinge, foreground left, and Ruth Hussey, foreground right, in a scene from TENDER COMRADE, 1943. 8x10 b&w photographic print
Tribute to John Thomson
No full textTHE MOTIVE OF HISTORY is at bottom poetic." Those significant words of Trevelyan were used by John Thomson to introduce a speech acknowledging his receipt of the Composers Association of New Zealand Citation for Services to New Zealand Music in February 1988. And there is poetry in all John's writings; poetry in the finesse of their polished presentation as well as in their psychological origins. Until the end of his life, John declined to be called a musicologist, preferring instead the term music historian. He considered history writing to be a noble profession. As an historian of New Zealand music, his avowed aim was to create a "sense of community, not only with the present but also with the past" and thereby "satisfy a craving we all have for a valid, dynamic history." In the end he achieved that goal, but it cost him many years of labour, not to mention incidents of thanklessness and hurtful controversy. It is too soon, yet, to gauge exactly the full measure of John's musical history making contribution to this country, but I feel sure time will reveal it to be substantially greater than most musicians here are currently aware of. He succeeded in laying the foundation stones of our music history, uncovering artistic vitality and continuity where previously there had been vagueness or ignorance
Kim Hunter, Patricia Collinge, Ginger Rogers, and others in TENDER COMRADE, 1943
No full textRichard Martin and, clockwise from left, Kim Hunter, Patricia Collinge, Ginger Rogers, and Ruth Hussey in a scene from TENDER COMRADE, 1943. 8x10 b&w photographic print
A novel protective prion protein variant that colocalizes with kuru exposure.
No full textBACKGROUND: Kuru is a devastating epidemic prion disease that affected a highly restricted geographic area of the Papua New Guinea highlands; at its peak, it predominantly affected adult women and children of both sexes. Its incidence has steadily declined since the cessation of its route of transmission, endocannibalism. METHODS: We performed genetic and selected clinical and genealogic assessments of more than 3000 persons from Eastern Highland populations, including 709 who participated in cannibalistic mortuary feasts, 152 of whom subsequently died of kuru. RESULTS: Persons who were exposed to kuru and survived the epidemic in Papua New Guinea are predominantly heterozygotes at the known resistance factor at codon 129 of the prion protein gene (PRNP). We now report a novel PRNP variant--G127V--that was found exclusively in people who lived in the region in which kuru was prevalent and that was present in half of the otherwise susceptible women from the region of highest exposure who were homozygous for methionine at PRNP codon 129. Although this allele is common in the area with the highest incidence of kuru, it is not found in patients with kuru and in unexposed population groups worldwide. Genealogic analysis reveals a significantly lower incidence of kuru in pedigrees that harbor the protective allele than in geographically matched control families. CONCLUSIONS: The 127V polymorphism is an acquired prion disease resistance factor selected during the kuru epidemic, rather than a pathogenic mutation that could have triggered the kuru epidemic. Variants at codons 127 and 129 of PRNP demonstrate the population genetic response to an epidemic of prion disease and represent a powerful episode of recent selection in humans
Collinge et al. reply
No full textREPLYING TO H. H. H. Adams, S. A. Swanson, A. Hofman & M. A. Ikram Nature 537, http://dx.doi.org/10.1038/nature19086 (2016)
Kroll, Dimitriadis, et al., 2022. Prion protein gene mutation detection using long-read Nanopore sequencing
No full textVersion uploaded 17/04/2022.
Data for
François Kroll*, Athanasios Dimitriadis*, Tracy Campbell, Lee Darwent, John Collinge, Simon Mead, Emmanuelle Viré. 2022.
*co-first authors
Prion protein gene mutation detection using long-read Nanopore sequencing.
https://doi.org/10.1101/2022.03.06.22271294
Present Zenodo archive contains heavier data files. Smaller files and code are available at GitHub repositories:
https://github.com/athanadd/prnp-nanopore-seq
https://github.com/francoiskroll/prnp_nanopore
Note, fast5 sequencing files were too heavy to be uploaded. Get in touch if you would like to access them.
If you use some of the data or code, please cite.
___
Get in touch for questions/suggestions
Twitter: @francois_kroll
Email: [email protected]
John McGahern - b. 1934
No full textJohn McGahern’s work has dominated the Irish literary landscape for almost forty years. First rendered famous by his first novel The Barracks, the writer then underwent the painful process of censorship and self-imposed exile after the banning of The Dark. If the following novels, The Leavetaking, The Pornographer and Amongst Women have aroused increasing interest in his work and attracted praise and controversy, the three collections of short stories, Nightlines (1970), Getting Through (1978..
- …
