1,828 research outputs found
Supplemental Material, Appendix_revise_11-06-2018 - The Reversal of Bleeding Caused by New Oral Anticoagulants (NOACs): A Systematic Review and Meta-Analysis
No full textSupplemental Material, Appendix_revise_11-06-2018 for The Reversal of Bleeding Caused by New Oral Anticoagulants (NOACs): A Systematic Review and Meta-Analysis by Sariya Udayachalerm, Sasivimol Rattanasiri, Teeranan Angkananard, John Attia, Nakarin Sansanayudh, and Ammarin Thakkinstian in Clinical and Applied Thrombosis/Hemostasis</p
Supplemental material for Contemporary prognosis of transient ischemic attack patients: A systematic review and meta-analysis
No full textSupplemental Material for Contemporary prognosis of transient ischemic attack patients: A systematic review and meta-analysis by Nashwa Najib Parker Magin, Daniel Lasserson, Debbie Quain, John Attia, Christopher Oldmeadow, Carlos Garcia-Esperon and Christopher Levi in International Journal of Stroke</p
Figure_1_correlation_image_1 – Supplemental material for Staff perspectives from Australian hospitals seeking to improve implementation of thrombolysis care for acute stroke
No full textSupplemental material, Figure_1_correlation_image_1 for Staff perspectives from Australian hospitals seeking to improve implementation of thrombolysis care for acute stroke by Christine Paul, Catherine D’Este, Annika Ryan, Amanda Jayakody, John Attia, Christopher Oldmeadow, Erin Kerr, Frans Henskens, Alice Grady and Christopher R Levi in SAGE Open Medicine</p
Longitudinal analysis of lung function in pregnant women with and without asthma
No full textAbstract not available.Megan E. Jensen, Annelies L. Robijn, Peter G. Gibson, Christopher Oldmeadow, Vicki Clifton, Warwick Giles, Vanessa E. Murphy, Andrew Woods, Kirsten McCaffery, Joerg Mattes, Michael Peek, Andrew Bisits, Leonie Callaway, Helen Barrett, John Attia, Christopher Doran, Sean K.M. Seeho, Paul Colditz, Andrew Searles and Alistair Abbot
Surgical management of jones fractures in athletes: orthobiologic augmentation: a systematic review and meta-analysis of 718 fractures
No full textBackground: The use of orthobiologics is expanding. However, the use of orthobiologic augmentation in primary fracture fixation surgery remains limited. Primary fracture fixation of the fifth metatarsal (Jones) in athletes is one of the rare situations where primary orthobiologic augmentation has been advocated.
Purpose: To determine the effect of orthobiologic augmentation on the outcome of surgically managed Jones fractures in athletes.
Study design: Systematic review; Level of evidence, 4.
Methods: Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, 2 independent team members searched several databases including PubMed, MEDLINE, Embase, Google Scholar, Web of Science, Cochrane Library, and ClinicalTrials.gov through March 2021 to identify studies reporting on surgically managed Jones fractures of the fifth metatarsal exclusively in athletes. The primary outcomes were the return to play (RTP) rate and time to RTP, whereas the secondary outcomes were time to union, union rate, and refractures. Data were presented by type of treatment (biologically augmented fixation or fixation alone).
Results: In the biologically augmented fixation group, successful RTP was reported in 195 (98.98%) of 197 fractures (odds ratio [OR], 97.5%; 95% CI, 95.8%-100%; I2 = 0), with a mean time to RTP of 10.3 weeks (95% CI, 9.5-11.1 weeks; I2 = 99%). In the group that received fixation without biological augmentation, successful RTP was reported in 516 (99.04%) of 521 fractures (OR, 98.7%; 95% CI, 97.8%-99.7%; I2 = 0], with a mean time to RTP of 9.7 weeks (95% CI, 7.84-11.53 weeks; I2 = 98.64%]. In the biologically augmented fixation group, fracture union was achieved in 194 (98.48%) of 197 fractures (OR, 97.6%; 95% CI, 95.5%-99.7%; I2 = 0%), with a mean time to fracture union of 9.28 weeks (95% CI, 7.23-11.34 weeks; I2 = 98.18%). In the group that received fixation without biological augmentation, fracture union was achieved in 407 (93.78%) of 434 fractures (OR, 97.4%; 95% CI, 96%-98.9%; I2 = 0%), with a mean time to fracture union of 8.57 weeks (95% CI, 6.82-10.32 weeks; I2 = 98.81%).
Conclusion: Orthobiologically augmented surgical fixation of Jones fractures in athletes is becoming increasingly common, despite the lack of comparative studies to support this practice. Biologically augmented fixation of Jones fractures results in higher fracture union rates than fixation alone but similar rates of RTP and time to RTP. Although the current evidence recommends primary surgical fixation for the management of Jones fractures in athletes, further high quality comparative studies are required to establish the indication for orthobiologic augmentation
Net Zero Energy Buildings (NZEB): Concepts, Frameworks and Roadmap for Project Analysis and Implementation
No full texteditorial reviewedNet Zero Energy Buildings (NZEB): Concepts, Frameworks and Roadmap for Project Analysis and Implementation the author provide readers elements to understand, combine and contextualize their design decisions on Net Zero Energy Buildings. The book is based on learned lessons from NZEB design, construction, operation and integrating the most relevant topics such as Multidisciplinarity, Climate Sensitivity, Comfort requirements, Carbon footprint, Technology, Construction Quality, and Evidence Based Design.
Chapter one introduces the context of high performance buildings, chapter two overviews the definition of NZEB, chapter tree covers the performance thresholds for efficient buildings, chapter four covers the design process and its tools, chapter five covers comfort and indoor environmental quality, chapter six covers materials, chapter seven covers systems and building automation, chapter eight covers micro-grid and smart grid, chapter nine discusses construction quality, chapter ten discusses performance monitoring and post occupancy evaluation, chapter eleven brings case studies and the final chapter covers NZEB Roadmap and tools.
Professionals in the Architecture, Engineering and Construction industries will benefit of the definitions of the fundamental concepts of the area as well as from the practical approach to evaluating energy efficient building projects. Researchers and students in the area will find particularly interesting the worldwide case studies and articulation of concepts into an evaluation framework.11. Sustainable cities and communities13. Climate actio
Staff perspectives of a cardiology short stay unit
No full textObjective\ud
To evaluate staff perceptions about working environment, efficiency and the clinical safety of a cardiovascular intervention short stay unit (SSU) during the first year of operation.\ud
\ud
Design\ud
Postal questionnaire.\ud
\ud
Setting\ud
Cardiac catheterisation laboratory (CCL), coronary care unit (CCU), general cardiology ward (GCW) and the short stay unit (SSU) of a tertiary referral hospital situated in the mid coastal region of NSW.\ud
\ud
Subjects\ud
Cardiologists (including visiting medical officers [VMO]), cardiology fellows, cardiology advanced trainees and nurses.\ud
\ud
Results\ud
Responses on the working environment of the SSU and the discharge process were statistically significant. A substantial proportion of both nurses and doctors had concerns about patient safety, even though no adverse events were formally recorded in the database.\ud
\ud
Conclusions\ud
Though the participants of the survey agree on the efficiency of the SSU in providing beds to the hospital, they disagree on aspects that are important in the functioning of the SSU, including the working environment, patient selection and clinical safety. The results highlight potential issues that could be improved or addressed and are relevant to the rollout of SSUs across NSW
Cannabis and benzodiazepines as determinants of methadone trough plasma concentration variability in maintenance treatment: a transnational study
No full textPurpose: To assess tobacco, alcohol, cannabis and benzodiazepine use in methadone maintenance treatment (MMT) as potential sources of variability in methadone pharmacokinetics. Methods: Trough plasma (R)- and (S)-methadone concentrations were measured on 77 Australian and 74 Swiss MMT patients with no additional medications other than benzodiazepines. Simple and multiple regression analyses were performed for the primary metric, plasma methadone concentration/dose. Results: Cannabis and methadone dose were significantly associated with lower 24-h plasma (R)- and (S)-methadone concentrations/dose. The models containing these variables explained 14–16% and 17–25% of the variation in (R)- and (S)-methadone concentration/dose, respectively. Analysis of 61 patients using only CYP3A4 metabolised benzodiazepines showed this class to be associated with higher (R)-concentration/dose, which is consistent with a potential competitive inhibition of CYP3A4. Conclusion: Cannabis use and higher methadone doses in MMT could in part be a response to—or a cause of—more rapid methadone clearance. The effects of cannabis and benzodiazepines should be controlled for in future studies on methadone pharmacokinetics in MMT.Richard Hallinan, Séverine Crettol, Kingsley Agho, John Attia, Jacques Besson, Marina Croquette-Krokar, Robert Hämmig, Jean-Jacques Déglon, Andrew Byrne, John Ray, Andrew A. Somogyi, Chin B. Ea
- …
