52 research outputs found

    On the Orchestration of Cerebellar Output

    No full text

    On the Orchestration of Cerebellar Output

    No full text

    Contents under pressure : an analysis of media as a vehicle in Anderson High School

    No full text
    Anderson High School in Anderson, Indiana is a lower ranking public school. The reasons for these statistics are due to a variety of factors, particularly the high poverty rate. The purpose of high schools and education in general is to prepare individuals for post secondary lives, particularly in finding a career or seeking collegiate education or certification programs. There are multiple flaws present in the way this goal is accomplished in Anderson, primarily due to the ways in which information is presented and advertised. Many opportunities are present in ACSC, or the Anderson Community School Corporation, but are not engaged in by the students. The 2019 College and Career Fair served to demonstrate this, as the attendance was incredibly low for the number of opportunities that were made available and the amount of information that was present. This is likely due to two factors. The first factor is that the event was not well advertised, as students were not made aware of the event until two days before it occurred. The second, and far more important, factor is the differences in expectations between students and administration. The two parties have different values and ideas about the future and there is a massive communication barrier that is present. This is likely due to each group making assumptions about the other, and it must be traversed in order to provide students with the best possible futures.Thesis (B.?)Honors Colleg

    ESD

    No full text
    Access to thesis restricted until 12/2023Recent climate reports confirm that, globally, our attempts to mitigate disaster are not, as of yet, commensurate with the concerns of the 21st century (The Intergovernmental Panel on Climate Change [IPCC], 2022; World Meteorological Organization [WMO], 2022). Education systems across the globe are now more rapidly seeking ways to convey and address the challenges posed by anthropogenic climate change and environmental degradation, or those challenges that present formidable threats to the security of our planet and the well-being of its peoples and its systems. The rapid and widespread application of programs targeting sustainability and the different approaches across K-12 campuses and colleges in the United States (Rowe, 2007), combined with the lack of measures capable of evaluating these programs in their nuance (Warner & Elser, 2015), means we know little about their effectiveness (Veronese & Kensler, 2013) and thus little about how these efforts are contributing to the development of a citizenry that is aware of and oriented toward life-affirming practices. Partly to blame is the ambiguity that surrounds what “sustainability” is and “sustainability in context” actually looks like. This study, in part, seeks to engage with these complex dynamics by examining one school district, a recent U.S. Department of Education Green Ribbon School (ED GRS) award recipient, and its efforts to engage with ESD as a “whole-school” culture (Henderson & Tilbury, 2004). Ultimately, the purpose of this study is to examine how school branding communicates with these 21st century educational imperatives through an evaluation of district-led efforts to integrate ESD across grade levels and the school curriculum, analyzing the extent to which eco-progressive rhetoric aligns with institutional activity and interdisciplinary practice.Thesis (M.A.

    Novel all-optical planar and compact minimum-stage switches of size > or = 4*4

    No full text
    S.240-259Throughout the paper, novel all-optical planar 1-stage k*k-switches and compact minimum-stage k*k-switches in double-layer and multi-layer technique, are presented and analysed. In the first case, the number of k(k-1)/2 switches of size 2*2 ( identical to minimum of the Spanke-Benes network) are arranged in parallel instead of the number of k ( identical to maximum) cascaded 2*2-switches of the Spanke-Benes network. In the second case, the number of 2*2-switches depends on the geometry of the 'pipes' of the switches formed by the layers and waveguides [for a square it is 3k/2(k/2-1) for rearrangeable nonblocking and 3(k-1)k/2(k/2-1) for circuit switching networks]. The number of stages (NS) (horizontal cascaded) of the proposed compact switches for the nonblocking interconnection is NS=n.1 if the waveguides form an n.gon (n>or=3) for any size of the k*k-switch. In this way, the attenuation of optical signals passing through a photonic network may be minimized. In particular, for any size of a k*k-switch, dependent on the n-gon, the minimum NS is n-1=2 (triangle) or n-1=3 (square), etc. Thus the proposed switch concept is of complexity O(1), i.e. The NS is independent of the number of inputs/outputs. Additionally, the proposed switches are capable to operate in the circuit switching mode if and only if (iff) the parallelism increases by the factor k-1

    Potentiation of cerebellar purkinje cells facilitates whisker reflex adaptation through increased simple spike activity

    Get PDF
    Cerebellar plasticity underlies motor learning. However, how the cerebellum operates to enable learned changes in motor output is largely unknown. We developed a sensory-driven adaptation protocol for reflexive whisker protraction and recorded Purkinje cell activity from crus 1 and 2 of awake mice. Before training, simple spikes of individual Purkinje cells correlated during reflexive protraction with the whisker position without lead or lag. After training, simple spikes and whisker protractions were both enhanced with the spiking activity now leading behavioral responses. Neuronal and behavioral changes did not occur in two cell-specific mouse models with impaired long-term potentiation at their parallel fiber to Purkinje cell synapses. Consistent with cerebellar plasticity rules, increased simple spike activity was prominent in cells with low complex spike response probability. Thus, potentiation at parallel fiber to Purkinje cell synapses may contribute to reflex adaptation and enable expression of cerebellar learning through increases in simple spike activity

    Exploring the Activation of the Keap1-Nrf2-ARE Pathway by PAHs in Children's Toys

    Get PDF
    3138Background: Children are particularly susceptible to environmental pollutants. This study assessed the skin sensitisation risk associated with polycyclic aromatic hydrocarbons (PAHs), prevalent in toys. Objectives: To evaluate the skin sensitisation potential of PAHs using the KeratinoSens assay. Methods: Individual PAHs (acenaphthylene, anthracene, benzo[a]anthracene, benzo[a]pyrene (B[a]P), benzo[b]fluoranthene (B[b]F), benzo[e]pyrene, benzo[g,h,i]perylene, benzo[k]fluoranthene (B[k]F), chrysene, fluoranthene, fluorene, naphthalene, phenanthrene, pyrene and triphenylene) and ternary mixtures containing B[a]P were assessed for their ability to activate the Keap1-Nrf2-ARE pathway in human keratinocytes. The concentration addition model and additive index were used to predict and analyse mixture effects. Results: Among the individual PAHs, B[k]F demonstrated the most potent activation of the pathway, exhibiting a 34-fold higher potency relative to B[a]P. B[b]F, chrysene and B[a]P also exhibited significant activation, while the remaining PAHs displayed negligible or weak activation. Notably, PAH mixtures exhibited synergistic effects, except for those composed solely of potent sensitizers. Conclusions: This study provides the first assessment of the skin sensitization potential of these PAHs. The findings suggest that B[k]F, B[b]F and chrysene may pose a higher risk of skin sensitisation than previously thought. Additionally, the synergistic effects observed in mixtures highlight the importance of considering combined exposures when assessing PAH exposure risk.93
    corecore