32 research outputs found
A concise review on the cultivation of microalgal biofilms for biofuel feedstock production
No full textFunding Information: Authors duly acknowledge the grant received from Sharda University seed grant project (SUSF2001/01). Authors duly acknowledge the grant received from the Life Sciences Research Board, Defense Research and Development Organization (DRDO) (File No. LSRB/81/48222/LSRB-368/BTB/2020) and Department of Science and Technology (File No. CRD/2018/000022) for the accomplishment of this work. Kavindra Kumar Kesari and Janne Ruokolainen thanking Aalto University for providing an open access support. Funding Information: Open Access funding provided by Aalto University. Authors duly acknowledge the grant received from Sharda University seed grant project (SUSF2001/01). Authors duly acknowledge the grant received from the Life Sciences Research Board, Defense Research and Development Organization (DRDO) (File No. LSRB/81/48222/LSRB-368/BTB/2020) and Department of Science and Technology (File No. CRD/2018/000022) for the accomplishment of this work. Publisher Copyright: © 2022, The Author(s).The enormous capability of microalgae for biomass production and co-products has recently been widely researched from a range of research approaches. Microalgae biomass has been discovered as a suitable feedstock for biofuel generation in the third generation. Although they may easily be cultivated in the laboratory, commercial cultivation involves several important considerations, including design, expense, contamination risk, and hygiene. This paper reviews some conventional microalgal cultivation methods along with some harvesting techniques. A short note on the disadvantages of conventional microalgal biofilm cultivation and the need for advanced cultivation techniques are also listed. Further, it highlights some of the modern techniques used for the cultivation of biofilm-based microalgae. It also gives brief information on the various factors affecting the formation of microalgal biofilm. A detailed description of the application of microalgal biofilm concerning biofuel generation is also reviewed. Graphical abstract: [Figure not available: see fulltext.]Peer reviewe
Aphid Cluster Recognition and Detection in the Wild Using Deep Learning Models
No full text@inproceedings{zhang2023new,
title={A New Dataset and Comparative Study for Aphid Cluster Detection},
author={Zhang, Tianxiao and Li, Kaidong and Chen, Xiangyu and Zhong, Cuncong and Luo, Bo and Teran, Ivan Grijalva and McCornack, Brian and Flippo, Daniel and Sharda, Ajay and Wang, Guanghui},
booktitle={2nd AAAI Workshop on AI for Agriculture and Food Systems},
year={2023}
Focus on underserved patients: Improving the collection of PROMs within the HIV outpatient clinic of the Amsterdam UMC
No full textBackground:The HIV outpatient clinic of Amsterdam University Medical Centers (AUMC)is implementing digital patient-reported outcomes measures (PROMS) in routine care to improve the quality of life (QoL) for people living with HIV (PWH). We were asked to design tools to promote the participation of patient groups from Ghana and Nigeria.Methods:Two sets of methodologies were used: qualitative research methods informed the development of a ‘patient journey’ and design-thinking methodologies informed the tool development. Participant observation and in-depth semi-structured interviews were conducted to gain insights into patient- and system-related characteristics. Design-thinking methodologies facilitated the transformation of qualitative data into insights that drove design concepts. Three ideation methodologies were used to create four concepts, leading to the final concept.Results:Observations of 17 individual consultations (6 female, 11 male) at the HIV outpatient clinic resulted in six recurring themes. These themes were: Personal relationship; Disclosure; Impact of the diagnosis; Health literacy & Health involvement; Communication; No-shows. The observations and additional literature research informed the development of an interview guide. Seven interviews (5 female, 2 male) were conducted with participants from Ghana and Nigeria. The observations and interviews informed the patient journey (PJ). The PJ showed that patients experience stress and anxiety prior to and during their hospital visit but fully trust doctors and nurses. Based on the insights the design challenge was addressed, leading to the following concepts: “Peer support community”; “Wellbeing Diary”; “Waiting Room Inspiration”; “Hospital Roadmap”.Conclusions:Amsterdam UMC will adopt the “Wellbeing Diary” which embodies the following characteristics: independence from relying on other organisations or infrastructure for implementation; a visual design that can be used independent of literacy level; and its affordability. The paper diary will provide a low-threshold tool for people to record PROMs-like experiences that will prepare them for their consultations at the outpatient clinic.Design for Interaction | Medisig
Studies on stabilization of lipase from Aspergillus niger
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Wastewater Treatment and Reuse: a Review of its Applications and Health Implications
No full textFunding Information: All the authors are highly grateful to the authority of the respective departments and institutions for their support in doing this research. The author VT would like to thank Science & Engineering Research Board, New Delhi, India (Grant #ECR/2017/001809). The Author RS is thankful to the University Grants Commission for the National Fellowship (201819-NFO-2018-19-OBC-UTT-78476). Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.Water scarcity is one of the major problems in the world and millions of people have no access to freshwater. Untreated wastewater is widely used for agriculture in many countries. This is one of the world-leading serious environmental and public health concerns. Instead of using untreated wastewater, treated wastewater has been found more applicable and ecofriendly option. Moreover, environmental toxicity due to solid waste exposures is also one of the leading health concerns. Therefore, intending to combat the problems associated with the use of untreated wastewater, we propose in this review a multidisciplinary approach to handle wastewater as a potential resource for use in agriculture. We propose a model showing the efficient methods for wastewater treatment and the utilization of solid wastes in fertilizers. The study also points out the associated health concern for farmers, who are working in wastewater-irrigated fields along with the harmful effects of untreated wastewater. The consumption of crop irrigated by wastewater has leading health implications also discussed in this review paper. This review further reveals that our current understanding of the wastewater treatment and use in agriculture with addressing advancements in treatment methods has great future possibilities.Peer reviewe
Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies
No full textFunding Information: Dr. Niraj Kumar Jha is thankful to Sharda University for the infrastructure and facility. The author would like to thank Deanship of Scientific Research at Majmaah University for supporting this work under project number No. R-2022-68 . Kavindra Kumar Kesari and Janne Ruokolainen thanking Aalto University for providing open access support. The authors would like to acknowledge the support from their respective institutes throughout the review writing process.Purpose: Cervical cancer (CC), one of the major causes of death of women throughout the world is primarily caused due to Human Papilloma Virus (HPV) 16 and 18. The early region (E) oncoproteins of HPV are associated with the etiopathogenesis and contribute to the progression of cancer. The present article comprehensively discussed the structural organization and biological functions of all E proteins of HPV and their contribution to progression of CC with an intent to decipher the pathological hallmarks and their relationship. Additionally, the role of E proteins in reference to therapeutics will also be presented. Methods: A systematic search has been carried out for articles published in PubMed database by using combinations of different keywords with Boolean operators (AND, OR, NOT) including cervical cancer, HPV, E proteins, and signaling. Results: From the analysis of literature review, its apparent that E proteins are the major contributor to disease progression. E1, E2, and E4 forms are mainly associated with viral integration, replication, and transcription whereas E6 and E7 act as an oncoprotein and are associated with the progression of cancer. E5 regulates cell proliferation, apoptosis, and facilitates the activity of E6 and E7. Additionally, E proteins were observed associated with numerous cell signaling pathways including PI3K/AKT, Wnt, Notch and reasonably contribute to the initiation of malignancy, cell proliferation, metastasis, and drug resistance. Knowing the role and interplay of each protein in initiation to progression of CC, their therapeutic significance has been elucidated. The present study observations demonstrate that E6 and E7 are the major cause of HPV-mediated CC progression. E1, E2, and E5 also act as a backbone for E6 and E7 and most of the current approaches have targeted E6 and E7 mediated action only. Conclusion: The present review illustrates the structural organization as well as function and regulation of all early proteins of HPV and their association with several cellular signaling pathways. The observations provide clue on the regulatory aspect of these proteins in initiation to progression and reasonably represent that targeting these proteins could be a novel therapeutic strategy for CC. In particular, its seemingly appears that inhibition of the activity of E6 and E7 oncoproteins may be a better selective target to delay the progression of CC. The review reaffirms the role of E proteins and encourages future studies on developing diagnostics, and most importantly therapeutics strategies targeting E6 and E7 oncoproteins to tackle CC related morbidity and mortality.Peer reviewe
Inadequacies of the Transgender Persons’ (Protection of Rights) Act, 2019: A Juxtaposition with International Legal Frameworks & Conventions
No full textBy way of safeguarding the rights of transgender individuals, the Indian government enacted the Transgender Persons’ (Protection of Rights) Act 2019. Studies show that the Act does not fully comply with many international treaties that aim to safeguard the rights of and provide safeguards for transgender individuals. To commence, to acquire a certificate of identity, transgender individuals are required to undergo a screening procedure administered by a medical officer and a District Magistrate to be certified. This requirement contradicts the idea of self-identification that is highlighted in international treaties such as the Yogyakarta Principles and the Inter-national Covenant on Civil and Political Rights (ICCPR). In this article, the author conducts a comparative study of the provisions that should be promptly added to the Act to give it the necessary prominence that has been overdue
Knowledge work and communication challenges in networked enterprises
No full textA modern enterprise is a heavily wired and networked socio-technical system where multiple components play in symphony to yield a competitive position in the ear of digital economy. While the underling communication and interaction systems facilitate knowledge workers to carry out the enterprise mission and furnish service to the society, there are many other aspects that rather have adverse effects on the productivity of an enterprise and interruption of knowledge workers, which pose a serious scientific challenge. In this paper, we briefly discuss certain challenging aspects of knowledge work and communication processes in networked enterprises that require more profound scientific attention in networked enterprises. This paper introduces the problem, identifies some specific research challenges, and then briefly discusses emerging research that addresses some of these challenges.Multi Actor SystemsTechnology, Policy and Managemen
Molecular Insights into Therapeutic Potentials of Hybrid Compounds Targeting Alzheimer’s Disease
No full textAlzheimer’s disease (AD) is one of the most complex progressive neurological disorders involving degeneration of neuronal connections in brain cells leading to cell death. AD is predominantly detected among elder people (> 65 years), mostly diagnosed with the symptoms of memory loss and cognitive dysfunctions. The multifarious pathogenesis of AD comprises the accumulation of pathogenic proteins, decreased neurotransmission, oxidative stress, and neuroinflammation. The conventional therapeutic approaches are limited to symptomatic benefits and are ineffective against disease progression. In recent years, researchers have shown immense interest in the designing and fabrication of various novel therapeutics comprised of naturally isolated hybrid molecules. Hybrid therapeutic compounds are developed from the combination of pharmacophores isolated from bioactive moieties which specifically target and block various AD-associated pathogenic pathways. The method of designing hybrid molecules has numerous advantages over conventional multitarget drug development methods. In comparison to in silico high throughput screening, hybrid molecules generate quicker results and are also less expensive than fragment-based drug development. Designing hybrid-multitargeted therapeutic compounds is thus a prospective approach in developing an effective treatment for AD. Nevertheless, several issues must be addressed, and additional researches should be conducted to develop hybrid therapeutic compounds for clinical usage while keeping other off-target adverse effects in mind. In this review, we have summarized the recent progress on synthesis of hybrid compounds, their molecular mechanism, and therapeutic potential in AD. Using synoptic tables, figures, and schemes, the review presents therapeutic promise and potential for the development of many disease-modifying hybrids into next-generation medicines for AD
