152 research outputs found
Temporomandibular Joint Pain is Negatively Correlated to TNF Alpha and Osteoprotegrin Content in Synovial Fluid in Patients with Juvenile Idiopathic Arthritis.
No full textObjective: Temporomandibular joint (TMJ) involvement occurs in up to 80% of children with juvenile idiopathic arthritis (JIA). Little is known with regard to the complexity of the protein profile in synovial fluid (SF) from JIA arthritis during growth as compared to both JIA and rheumatoid arthritis (RA) of adults.
Design: Synovial fluid was collected from 54 joints/30 patients with TMJ arthritis (JIA 35 joints/20 patients, JIA adults 9 joints/5 patients, RA 10 joints/5 patients). Three cytokines and seven bone markers were quantified using Luminex multiplex assays and compared to demographic and clinical data of function and pain.
Results: Pain (spontaneous and upon palpation) and duration of pain were all negatively correlated with the TMJ SF content of tumor necrosis factor (TNF)-α. The level of Adrenocorticotropic hormone (ACTH) was negatively correlated to TMJ pain upon palpation and post-treatment pain and function. The concentration of ACTH was significantly lower in SF in JIA (1.4 ± 2.8 pg/ml) compared to adults with JIA (4.7 ± 12.2 pg/ml) and significantly higher compared to adults with RA (0.8 ± 1.5 pg/ml). Osteoprotegerin (OPG) was negatively correlated to spontaneous pain.
Conclusions: Our results indicate that the local concentrations of TNF-α, ACTH and OPG in TMJ fluid may not contribute to TMJ pain and tissue destruction in JIA/RA patients.
© 2014 Olsen-Bergem H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Kwaliteit van arbeid, geautomatiseerd... Een studie naar kwaliteit van arbeid en de relatie tussen automatisering, arbeid en organisatie
No full textTechnology, Policy and Managemen
Crayfish optimization algorithm
No full textThis paper proposes a meta heuristic optimization algorithm, called Crayfish Optimization Algorithm (COA), which simulates crayfish’s summer resort behavior, competition behavior and foraging behavior. The three behaviors are divided into three different stages to balance the exploration and exploitation of algorithm. The three stages are summer resort stage, competition stage and foraging stage. The summer resort stage represents the exploration stage of the COA. The competition stage and foraging stage represent the exploitation stage of the COA. Exploration and exploitation of COA are regulated by temperature. When the temperature is too high, crayfish will enter the cave for summer vacation or compete for the same cave. When the temperature is appropriate, crayfish have different foraging behaviors according to the size of food. Among them, the amount of food eaten by crayfish is related to food intake. Through temperature regulate exploration and exploitation process in COA, the COA has higher randomness and global optimization effect. To verify the optimization effect of COA, in the experimental part, 23 standard benchmark functions and CEC2014 benchmark functions are used to test, and 9 algorithms are selected for comparative experiments. The experimental results show that COA can balance the exploration and exploitation, and achieve good optimization effect. Finally, the COA is tested in five engineering problems, and finally achieves better results. The source code website for COA is https://github.com/rao12138/COA-s-code .No Full Tex
Damage detection in semiconductor devices by non-linear elastic wave spectroscopy
No full textSemiconductor devices can be found everywhere in our daily lives, for example in self-driving cars, bank cards and personal devices such as smart phones or notebooks. Once part of these personal devices, one does not want them to show failure. Although reliability of such devices is taken into account in the design, the fabrication process might lead to the emergence of small damages in the product. Since these damages or their propagation might cause failure of the device, a series of visual inspections and functional tests is part of the fabrication process. The obtained resolution by optical microscopy, currently the state of the art inspection method, is not sufficient for the detection of small damages such as microcracks or damages located inside a sample. To keep improving the reliability of semiconductor devices, these damages need to be detected in another high speed, low cost way.As semiconductor devices shrink in size, their natural vibration frequencies increase and approach theMHz-range. Vibration based damage detection methods might therefore offer an alternative high speed in-situ inspection method. The main goal of this thesis is to identify and experimentally verify vibration characteristics that indicate the presence of damage, with a focus on microcracks, in semiconductor devices. While linear vibration based damage methods have proven to be insensitive to small damages such as microcracks, non-linear vibration based damage detection methods show much higher sensitivities to this type of damage. The non-linear elastic wave spectroscopy (NEWS) of several damaged materials have shown two characteristic phenomena: amplitude dependent natural frequency shifts and the generation of higher harmonics. Both are explained by a phenomenological non-linear hysteric elastic model. While the applicability of NEWS is proven for several materials, its performance for silicon, in particular at microscale, is still unknown.Mechanical Engineering | Micro and Nano Engineerin
The drama of the forests, romance and adventure, by Arthur Heming; illustrated by the author with reproductions from a series of his paintings owned by the Royal Ontario museum.
No full textxiii, 324 p
Temporomandibular joint (TMJ) arthritis in Juvenile Idiopathic Arthritis (JIA): Clinical management and analyses of TMJ synovial fluid
No full textA geometric flow on noncompact affine Riemannian manifolds
No full textIn this paper, we obtain the existence criteria for a geometic flow on
noncompact affine Riemannian manifolds. Our results can be regarded as a real
version of Lee-Tam [19]. As an application, we prove that a complete noncompact
Hessian manifold with nonnegative Hessian sectional curvature and bounded
geometry is diffeomorphic to if its tangent bundle has maximal
volume growth.Comment: arXiv admin note: text overlap with arXiv:math/0504422,
arXiv:1708.00141 by other author
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