14,576 research outputs found
sj-pdf-3-imr-10.1177_03000605231152100 - Supplemental material for Lidocaine inhibits osteogenic differentiation of human dental pulp stem cells <i>in vitro</i>
No full textResearch Data for Lidocaine inhibits osteogenic differentiation of human dental pulp stem cells in vitro by Eun-Jung Kim, Ji-Uk Yoon, Cheul-Hong Kim, Ji-Young Yoon, Joo-Young Kim, Hyang-Sook Kim and Eun-Ji Choi in Journal of International Medical Research</p
sj-pdf-1-imr-10.1177_03000605231152100 - Supplemental material for Lidocaine inhibits osteogenic differentiation of human dental pulp stem cells <i>in vitro</i>
No full textResearch Data for Lidocaine inhibits osteogenic differentiation of human dental pulp stem cells in vitro by Eun-Jung Kim, Ji-Uk Yoon, Cheul-Hong Kim, Ji-Young Yoon, Joo-Young Kim, Hyang-Sook Kim and Eun-Ji Choi in Journal of International Medical Research</p
sj-pdf-2-imr-10.1177_03000605231152100 - Supplemental material for Lidocaine inhibits osteogenic differentiation of human dental pulp stem cells <i>in vitro</i>
No full textResearch Data for Lidocaine inhibits osteogenic differentiation of human dental pulp stem cells in vitro by Eun-Jung Kim, Ji-Uk Yoon, Cheul-Hong Kim, Ji-Young Yoon, Joo-Young Kim, Hyang-Sook Kim and Eun-Ji Choi in Journal of International Medical Research</p
RealWear
No full textNAND flash memory has revolutionized how we manage data in modern digital systems, significant improvements are needed in flash-based storage systems to meet the requirements of emerging data-intensive applications. In this paper, we address the problem of NAND aging markers that represent the wearing degree of NAND cells. Since all flash operations are affected by the wearing status of NAND cells, an accurate NAND aging marker is critical to develop flash optimization techniques. From our evaluation study, we first show that the existing P/E cyclebased aging marker (PeWear) is inadequate to estimate the actual aging status of NAND blocks, thus losing opportunities for further optimizations. To overcome the limitations of PeWear, we propose a new NAND aging marker, RealWear, based on extensive characterization studies using real 3D TLC flash chips. By considering multiple variables that can affect the NAND cell wear, RealWear can accurately indicate the actual wear status of NAND blocks during run time. Using three case studies, we demonstrate that RealWear is effective in enhancing the lifetime and performance of a flash storage system. Our experimental results showed that RealWear can extend the lifetime of individual NAND blocks by 63% and can reduce the GC overhead by 21%. Furthermore, RealWear significantly mitigates read latency fluctuations, guaranteeing that the read latency can be bounded with at most 2 read retry operations. © 2021 Copyright is held by the owner/author(s).N
sj-jpg-2-tag-10.1177_17562848221137430 – Supplemental material for Risk of prostate cancer in patients with inflammatory bowel disease: a nationwide cohort study in South Korea
No full textSupplemental material, sj-jpg-2-tag-10.1177_17562848221137430 for Risk of prostate cancer in patients with inflammatory bowel disease: a nationwide cohort study in South Korea by Ji Eun Na, Tae Jun Kim, Yeong Chan Lee, Ji Eun Kim, Eun Ran Kim, Sung Noh Hong, Dong Kyung Chang and Young-Ho Kim in Therapeutic Advances in Gastroenterology</p
sj-docx-1-tag-10.1177_17562848221137430 – Supplemental material for Risk of prostate cancer in patients with inflammatory bowel disease: a nationwide cohort study in South Korea
No full textSupplemental material, sj-docx-1-tag-10.1177_17562848221137430 for Risk of prostate cancer in patients with inflammatory bowel disease: a nationwide cohort study in South Korea by Ji Eun Na, Tae Jun Kim, Yeong Chan Lee, Ji Eun Kim, Eun Ran Kim, Sung Noh Hong, Dong Kyung Chang and Young-Ho Kim in Therapeutic Advances in Gastroenterology</p
Loss of IQSEC3 Disrupts GABAergic Synapse Maintenance and Decreases Somatostatin Expression in the Hippocampus
Get PDFGephyrin interacts with various GABAergic synaptic proteins to organize GABAergic synapse development. Among the multitude of gephyrin-binding proteins is IQSEC3, a recently identified component at GABAergic synapses that acts through its ADP ribosylation factor-guanine nucleotide exchange factor (ARF-GEF) activity to orchestrate GABAergic synapse formation. Here, we show that IQSEC3 knockdown (KD) reduced GABAergic synaptic density in vivo, suggesting that IQSEC3 is required for GABAergic synapse maintenance in vivo. We further show that IQSEC3 KD in the dentate gyrus (DG) increases seizure susceptibility and triggers selective depletion of somatostatin (SST) peptides in the DG hilus in an ARF-GEP activity-dependent manner. Strikingly, selective introduction of SST into SST interneurons in DG-specific IQSEC3-KD mice reverses GABAergic synaptic deficits. Thus, our data suggest that IQSEC3 is required for linking gephyrin-GABAA receptor complexes with ARF-dependent pathways to prevent aberrant, runaway excitation and thereby contributes to the integrity of SST interneurons and proper GABAergic synapse maintenance. © 2020 The Author(s)
In this study, Kim et al. investigate the effect of loss of function of IQSEC3, a gephyrin-binding GABAergic synapse-specific ARF-GEF, using hippocampal dentate gyrus (DG)-specific IQSEC3-knockdown (KD) mice. Strikingly, IQSEC3 KD causes a massive reduction of somatostatin (SST) expression. The restricted SST expression in SST+ interneurons reverses the pathological phenotypes. © 2020 The Author(s)1
DS1_JVDI_10.1177_1040638719830760 – Supplemental material for An optimized molecular method for detection of influenza A virus using improved generic primers and concentration of the viral genomic RNA and nucleoprotein complex
No full textSupplemental material, DS1_JVDI_10.1177_1040638719830760 for An optimized molecular method for detection of influenza A virus using improved generic primers and concentration of the viral genomic RNA and nucleoprotein complex by Ji-Woon Kim, Chung-Young Lee, Thanh Trung Nguyen, Il-Hwan Kim, Hyuk-Joon Kwon and Jae-Hong Kim in Journal of Veterinary Diagnostic Investigation</p
DS1_JVDI_10.1177_1040638719832071 – Supplemental material for Evaluation of a human glycated hemoglobin test in canine diabetes mellitus
No full textSupplemental material, DS1_JVDI_10.1177_1040638719832071 for Evaluation of a human glycated hemoglobin test in canine diabetes mellitus by Na-Yon Kim, Jaehoon An, Jae-Kyung Jeong, Sumin Ji, Sung-Hyun Hwang, Hong-Seok Lee, Myung-Chul Kim, Hyun-Wook Kim, Sungho Won and Yongbaek Kim in Journal of Veterinary Diagnostic Investigation</p
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