1,230 research outputs found
Long Noncoding RNAs: Emerging Players in Medulloblastoma
No full textCentral Nervous System tumors are the leading cause of cancer-related death in children, and medulloblastoma has the highest incidence rate. The current therapies achieve a 5-year survival rate of 50–80%, but often inflict severe secondary effects demanding the urgent development of novel, effective, and less toxic therapeutic strategies. Historically identified on a histopathological basis, medulloblastoma was later classified into four major subgroups—namely WNT, SHH, Group 3, and Group 4—each characterized by distinct transcriptional profiles, copy-number aberrations, somatic mutations, and clinical outcomes. Additional complexity was recently provided by integrating gene- and non-gene-based data, which indicates that each subclass can be further subdivided into specific subtypes. These deeper classifications, while getting over the typical tumor heterogeneity, indicate that different forms of medulloblastoma hold different molecular drivers that can be successfully exploited for a greater diagnostic accuracy and for the development of novel, targeted treatments. Long noncoding RNAs are transcripts that lack coding potential and play relevant roles as regulators of gene expression in mammalian differentiation and developmental processes. Their cell type- and tissue-specificity, higher than mRNAs, make them more informative about cell- type identity than protein-coding genes. Remarkably, about 40% of long noncoding RNAs are expressed in the brain and their aberrant expression has been linked to neuro-oncological disorders. However, while their involvement in gliomas and neuroblastomas has been extensively studied, their role in medulloblastoma is still poorly explored. Here, we present an overview of current knowledge regarding the function played by long noncoding RNAs in medulloblastoma biology
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Introduction to Optimising Female Athletic Performance
No full textFrom our own research into the field of female athletic performance we have concluded that there is an increasing demand for greater knowledge and understanding of the multidimensional influences on the performance of female athletes. Throughout their lives females will go through significant lifecycle changes. These changes commence during childhood as they move through puberty, into their adolescent years, onto adulthood and potentially motherhood. Following that, they move into their menopausal and postmenopausal stages. Each stage of the lifecycle brings with it specific physical, psychological, and social challenges that can affect women’s performance, their attitudes towards physical activity and the amount of time that they can invest in it. While there is existing research in this area more knowledge is required to construct a comprehensive understanding of female athletes and assess the specific support they may need at different stages of their athletic development
Beyond Blame—Mens Rea and Regulatory Crime
No full textIn the first part of this Article, the Author briefly outlines the conceptual underpinnings of the common law approach to mens rea, with its blame focus, and the Supreme Court\u27s early efforts to develop a different approach in interpreting regulatory criminal statutes. The Author begins the second part of this Article with Lambert v. California, in which the Court staked out the constitutional limits for the employment of strict liability in public welfare or regulatory crimes, and, first employed notice-based mens rea. This part goes on to examine the ensuing cases in which the Court, at least implicitly, fleshes out the notice analysis that should guide the courts in deciding whether Congress intended strict liability or some level of mens rea in enacting regulatory criminal statutes. The Author concludes with Liparota v. United States, the case in which the Court departed from the emerging construct, which had distinguished blame-based and notice-based mens rea. This part then charts the doctrinal confusion that has resulted from this conflation of blame and notice in the Court\u27s mens rea analysis, confusion that is apparent not only in its own cases but also those of the circuit courts as they confront this vexatious problem
Fables d'Ésope
No full textFrom the original Favole published in 2011 by Topipittori in Milan. Here is a large-format (9 x 13¼) landscape -- rather than portrait -- book. I feel as though I have known it before, but I cannot find it in the database. The cover has a cat looking suspiciously around a table of fable characters, among whom is a stork dipping her beak deep into a tall glass. The back cover advertises correctly: Vingt fables amusantes, parfois cruelles, des plus connues aux plus surprenantes…. The illustrations are indeed provocative, starting with the first fable's dog sick from devouring a snail. Are we seeing his insides or the woods in which he found the snail? In FC, three foxes rejoice in carnival costume over the fresh piece of meat teased away from the crow, who holds his hands high in outrage. In DS, we can see the fish start to pick at the floating piece of meat. My favorite in the book is Prométhée et les hommes. Since animals outnumbered people, Zeus asked Prometheus to transform a number of the former into the latter. They have human form but bestial souls. Rea mixes human and animal faces nicely here. TMCM has the country rat, perched in a flower, turning his head toward a slightly open door. The cover pictures turns out to be a doubting illustration of the fable in which a just lion king has all the animals come together in peace. Rea suggests nicely that this plan may not work. I wonder why many fable books are published because they have little new to offer; I do not have that question about this excellent book!This is a hardbound book (hard cover)Language note: FrenchTraduit du grec ancien par Émile Chambr
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Careers in Sports Science
No full textThis book is aimed at students who are currently studying sports science at undergraduate level or studying BTECs in sport or sport and exercise science. The purpose of the book is to answer the big question:
What do you do with a sports science degree?
It is common that students know that they want to work in sport and work with people but are not sure exactly what they can do. This can affect their motivation while they study as they have no clear goal to work towards.
Based on interviews with 20 people who work in sports related occupations this is designed to provide direction and guidance to enable students to make informed decisions about what they could do with their qualification. The case studies include people who work to support performance athletes, such as a sports nutritionist, sport psychologist, sports analyst, exercise physiologist and a strength and conditioning coach. Also included are cases studies of sports coaches, personal trainers and teachers as well as broader career options such as sports massage therapy, sports development and sports journalism and broadcasting. Many of the people chosen as case studies work with Olympic or professional athletes.
As part of the case studies the importance of developing personal skills needed to work with athletes and other people are discussed. These discussions form the basis of a key chapter about the personal skills needed to work in sporting environments that are often unpredictable, complex and challenging. There is also important advice on how personal skills can be developed whilst studying and what else you should do during your studies to make yourself more employable.
There is an introductory chapter on the options for students who want to study sports science, or similar courses, at degree level with a focus on whether A-level or BTEC qualifications will be more beneficial to them. This chapter also assesses the value of degree level study to an individual’s career. There is a concluding chapter that examines how to apply for jobs and prepare for interviews once you have gained your qualification.
The author, Simon Rea, has worked as a performance coach and personal trainer as well as teaching in both higher and further education for over 25 years. He is a senior fellow of the Higher Education Academy and has written or contributed significantly to 14 books related to sports science
Knowledge as a Mens Rea Requirement
No full textThe term knowledge is used to represent the mens rea requirement of various crimes. The common law concept of that term included both guilty belief and guilty avoidance of knowledge. The Model Penal Code, however, does not provide for the latter common law concept. Noting this omission, the author proposes an amendment to the Code that would allow for satisfaction of the mens rea element of an offense on the basis of a deliberate avoidance of knowledge
Knowledge as a Mens Rea Requirement
No full textThe term knowledge is used to represent the mens rea requirement of various crimes. The common law concept of that term included both guilty belief and guilty avoidance of knowledge. The Model Penal Code, however, does not provide for the latter common law concept. Noting this omission, the author proposes an amendment to the Code that would allow for satisfaction of the mens rea element of an offense on the basis of a deliberate avoidance of knowledge
Bloc heads. by Rupert Pennant-Rea
No full textThe author takes issue with those who call for the formation of an East Asian trading bloc
Material saving by means of CWR technology using optimization techniques
No full textPublisher Copyright: © 2017 Author(s).Material saving is currently a must for the forging companies, as material costs sum up to 50% for parts made of steel and up to 90% in other materials like titanium. For long products, cross wedge rolling (CWR) technology can be used to obtain forging preforms with a suitable distribution of the material along its own axis. However, defining the correct preform dimensions is not an easy task and it could need an intensive trial-and-error campaign. To speed up the preform definition, it is necessary to apply optimization techniques on Finite Element Models (FEM) able to reproduce the material behaviour when being rolled. Meta-models Assisted Evolution Strategies (MAES), that combine evolutionary algorithms with Kriging meta-models, are implemented in FORGE® software and they allow reducing optimization computation costs in a relevant way. The paper shows the application of these optimization techniques to the definition of the right preform for a shaft from a vehicle of the agricultural sector. First, the current forging process, based on obtaining the forging preform by means of an open die forging operation, is showed. Then, the CWR preform optimization is developed by using the above mentioned optimization techniques. The objective is to reduce, as much as possible, the initial billet weight, so that a calculation of flash weight reduction due to the use of the proposed preform is stated. Finally, a simulation of CWR process for the defined preform is carried out to check that most common failures (necking, spirals,.) in CWR do not appear in this case.The research leading to these results received funding from the European Union´s Seventh Framework Program, managed by REA-Research Executive Agency (FP7/2007-2013) under grant agreement No. 606171 FP7-SME-2013-1 (CoVaForm). The research leading to these results received funding from the European Union's Seventh Framework Program, managed by REA-Research Executive Agency (FP7/2007-2013) under grant agreement No. 606171 FP7-SME-2013-1 (CoVaForm).Peer reviewe
The Notion Of Criminal Intent: The Evolution Of Mens Rea In Criminal Law
No full textThis thesis evaluates the legal concept of mens rea to better understand its meaning and significance in criminal law. Included in this thesis is the examination of the evolution of criminal law from Roman law to today's Canadian criminal law, through the lens of the foundational principle of mens rea, through its application in numerous Supreme Court of Canada cases, has either reinforced the interpretation of laws or set out a new framework on how the law should be interpreted. The purpose of this paper is to illustrate how mens rea guided criminal law by emphasizing the purpose of the justice system, the purpose and significance of the mental element within an offence; how the law is interpreted using the concept of mens rea, the degree of culpability within an offence; and a higher standard of burden of proof. Mens rea has many functions such as to guard against the wrongful conviction of morally innocent individuals and to protect our society from those who caused harm. Mens rea also helps distinguish between the degrees of moral blameworthiness within each crime and to understand the concept of burden of proof. Lastly, mens rea is critical in a court's determining of appropriate punishment. Finally, this thesis links the concept of mens rea to legal defences in criminal law
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