12 research outputs found
Unusual cause of gastrointestinal bleeding: multiple small bowel carcinoid tumours
No full textImages for SurgeonsAaron M. Thomas, Jesse D. Beumer, Aravind Suppiah and Peter G. Devit
Intramural oesophageal dissection
No full textIntramural oesophageal dissection is an uncommon but important clinical condition. It often occurs in patients who are anticoagulated, and the clinical presentation may include chest pain, dysphagia and haematemesis. The aim of this review was to determine an appropriate treatment algorithm for patients with suspected intramural oesophageal dissection. We conducted a literature review using PubMed and MedLine up until December 2008. We also reported on our own case series of three patients with intramural oesophageal dissection presenting at two Adelaide hospitals over the past 5 years. Recognition of the risk factors and clinical symptoms associated with this condition is imperative to avoid unnecessary and potentially harmful investigations and therapy. Intramural oesophageal dissection usually follows a benign course requiring conservative therapy only.Jesse D. Beumer, Peter G. Devitt and Sarah K. Thompso
Energy Efficiency Valuation: Estimating the increase in expected transaction price due to improved energy efficiency in the Dutch housing market
No full textRecent advancements in causal inference and machine learning research have brought forward methods to estimate effects of interventions from observational data. The augmented inverse probability weighted (AIPW) estimator is such a method, which can be used to obtain estimates of potential outcomes. Potential outcomes are defined as a hypothetical outcome pair {Y(1),Y(0)}, of which only one outcome is observed in the data. Estimation of intervention effects boils down to effectively estimating these potential outcomes.Using the AIPW estimator, we aim to evaluate the average effect of increasing the energy efficiency of houses in the Netherlands on their expected transaction price. Moreover, we investigate how this expected effect changes when we condition on a certain subset of the data.Given that our assumptions hold, we find that on average, the estimated expected increase in transaction price is positive when improving the energy efficiency of a house. Improving an energy inefficient house to moderately energy efficient is expected to increase the transaction price by approximately €97.70,- per m2, while the improvement from moderately energy efficient to energy efficient increases the expected transaction price by approximately €20.96 per m2. In general, older, smaller and more energy inefficient houses increase most in expected transaction price per m2 when their energy efficiency is improved.Applied Mathematic
Superdutch - Eine Kopfgeburt der Medien
No full textStatement on contemporary Dutch architecture for a special issue of the German weekly Baunetzwoche devoted to Dutch architecture.ArchitectureArchitecture and The Built Environmen
Hypersensitivity of BRCA1 heterozygote lymphoblastoid cells to gamma radiation and PARP inhibitors
No full textThis article is made available through the Brunel Open Access Publishing Fund. Copyright @ 2013 Bourton EC, et al. This is an open-access article distributed
under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the
original author and source are credited.PARP inhibitors can be used to induce synthetic lethality in cells with bi-allelic BRCA1 and BRCA2 mutations.
However the effect of PARP inhibitors in combination with radiation on cells with mono-allelic mutations of BRCA1
and BRCA2 is unknown. We have examined the cell survival response of lymphoblastoid cells derived from normal
individuals and those derived from carriers of BRCA1 and BRCA2 mutations, following exposure to ionising radiation
and the PARP inhibitor Olaparib.
Two lymphoblastoid cell lines from normal individuals and three with mono-allelic mutations in BRCA1 and
BRCA2 were exposed to increasing doses of gamma radiation either alone or in combination with 5 μM Olaparib.
Cell survival was measured using the MTT assay.
Exposure to increasing doses of gamma radiation caused a reduction in cell survival of all cell types. The
combined exposure to gamma radiation and 5 μM Olaparib did not enhance cell kill in normal or BRCA2 heterozygote
lymphoblastoid cells but significantly enhanced cell kill in cells derived from BRCA1 carriers (P = 0.02). The treatment
of cancer patients carrying mutations in the BRCA1 gene with radiotherapy and the PARP inhibitor Olaparib may
significantly enhance radiation induced normal tissue toxicity in these patients.Vidal Sassoon Foundation of America and “The Balls to Cancer” Charity, Coventry, U
Carbon nanoparticles in lateral flow methods to detect genes encoding virulence factors of Shiga toxin-producing Escherichia coli
No full textThe use of carbon nanoparticles is shown for the detection and identification of different Shiga toxin-producing Escherichia coli virulence factors (vt1, vt2, eae and ehxA) and a 16S control (specific for E. coli) based on the use of lateral flow strips (nucleic acid lateral flow immunoassay, NALFIA). Prior to the detection with NALFIA, a rapid amplification method with tagged primers was applied. In the evaluation of the optimised NALFIA strips, no cross-reactivity was found for any of the antibodies used. The limit of detection was higher than for quantitative PCR (q-PCR), in most cases between 10 4 and 10 5 colony forming units/mL or 0.1-0.9 ng/¿L DNA. NALFIA strips were applied to 48 isolates from cattle faeces, and results were compared to those achieved by q-PCR. E. coli virulence factors identified by NALFIA were in very good agreement with those observed in q-PCR, showing in most cases sensitivity and specificity values of 1.0 and an almost perfect agreement between both methods (kappa coefficient larger than 0.9). The results demonstrate that the screening method developed is reliable, cost-effective and user-friendly, and that the procedure is fast as the total time required is <1 h, which includes amplification. © 2010 The Author(s).This work was partially supported by the Generalitat Valenciana (BEST/2009/026), the Universidad Politecnica de Valencia (PAID-00-09-2837), and by the Dutch Ministry of Agriculture, Nature and Food Quality (KennisBasis 6 programme). The authors would like to thank Dr. Eva Moller Nielsen at the Danish Veterinary Institute (Copenhagen, Denmark) for providing E. coli control strains and Dr. Lutz Geue (Friedrich-Loeffler-Institut, Wusterhausen, Germany) and Dr. Dorte Dopfer (School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA) for field isolates.Noguera Murray, PS.; Posthuma-Trumpie, G.; Van Tuil, M.; Van Der Wal, F.; De Boer, A.; Moers, A.; Van Amerongen, A. (2011). Carbon nanoparticles in lateral flow methods to detect genes encoding virulence factors of Shiga toxin-producing Escherichia coli. 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No full textEnvironmental policy and technical change: a comparison of the technological impact of policy instruments.
No full textClustering dynamics and the location of high-tech firms
No full textThe location of productive activities and the emergence of clustering dynamics has been
an important research topic since the early works of Weber (1929) and Marshall (1920
and 1921). This thesis aims at relating the processes of firms' location decision and the
development of high-tech clusters within an encompassing theoretical and empirical
framework.
The thesis shows the empirical relevance of the clustering of high-tech sectors and
highlights the importance of the issue through the construction and use of an original
database on the location of high-tech establishments and employment (at two different
geographical levels) in four major industrialised countries. It also contains a critical
review of a number of different streams of theoretical and empirical literature which are
directly connected, or which have been explicitly put in connection by the author, with
the topic of study. In the thesis we develop a composite modelling framework for
analysing firms' location decisions and the growth of high-tech clusters, and we
empirically test a number of crucial hypotheses in order to draw some guidelines for
economic policy.
The models presented in the theoretical chapter derive from two different streams of
literature. The first derives from the analysis of population ecology, the second from the
theory of innovation diffusion. These modelling frameworks have stressed the existence
of a critical mass and a maximum dimension of the cluster and their effects on the early
and late phases of development within the "life cycle" of a cluster. They also highlighted
the role of rank, stock, order and epidemics effects in the location decision of an
individual firm which has to decide whether to locate into a developing cluster.
The empirical evidence presented in the thesis has focused on the crucial elements of the
location process by verifying the empirical relevance of different locational factors, has
stressed the relative importance of agglomeration versus scale economies in determining
the industrial specialisation of an area, and has measured the competitive effects which
arise between the development of different clusters and the synergistic effects which are
generated within the cluster. Finally the thesis presents empirical evidence which shows
that local competition and industrial specialisation are the key elements for the success
of an industrial cluster.
A final chapter extracts some crucial policy conclusions on the role of entry versus
growth policies, on the different development path that an industrial cluster may follow
depending on the excludability condition, presents an original taxonomy of specific
policies, applies some of these findings to a brief survey of the phenomenon of science
parks and finally produces a series of guidelines for policy makers.
The conclusion summarises the results obtained in the thesis and present a brief agenda
for future research
