2,940 research outputs found
Cure of codfish and herrings; Extracts for a work on the cure of codfish and herring
No full textUseful Hints on the Cure of Codfish and HerringsAt head of title: Official; "(Extracts from), reprinted, by permission, by H.M. inspectors for Irish Fisheries", "... having obtained the permission from Newfoundland Fisheries Commission ..." --page
Influenza the quest to cure the deadliest disease in history
No full textDr Jeremy Brown, a veteran ER doctor, explores the troubling, terrifying, and complex history of the flu virus, from the surprising origins of the 1918 flu that killed millions, to vexing questions such as: are we prepared for the next epidemic, should you get a flu shot, and how close are we to finding a cure? While influenza is now often thought of as a mild disease, it kills thousands of Australians each year. Dr Jeremy Brown, currently Director of Emergency Care Research at the National Institutes of Health, expounds on the flu's deadly past to solve the mysteries that could protect us from the next outbreak. In Influenza, he talks with leading epidemiologists, policy makers, and the researcher who first sequenced the genetic building blocks of the virus to offer both a comprehensive history and a roadmap for understanding what's to come. Dr Brown digs into the discovery and resurrection of the flu virus in the victims of the 1918 epidemic exhumed from the tundra, as well as the bizarre remedies that once treated the disease, such as fatal doses of aspirin and blood-letting. Influenza also breaks down the current dialogue surrounding the disease, explaining the controversy over vaccinations, antiviral drugs such as Tamiflu, and the federal government's role in preparing for a pandemic. Dr Brown warns that many of the most vital questions about the flu virus continue to confound even the leading expert
The cure for anxiety
No full textGod is not contained within the Bible, He is all around us. The cure for anxiety is to look for God and His will in situations filled with anxiety. The speaker uses personal and Biblical examples to prove his point
Cure-induced residual stresses for warpage reduction in thermoset laminates
No full textThe paper addresses the role played by the cure stage of a vacuum assisted resin transfer molding process in residual stresses generation. The Airstone 780E epoxy resin and Hardener 785H system broadly used in the wind turbine blade industry has been used in this study. The viscous–elastic properties of the resin have been characterized and implemented in a thermo-mechanical FE model. The model has been validated against manufactured [0/90]4 asymmetric laminates. Analysis of residual stresses generation highlighted that compressive stresses generation occurs when the cure is shrinkage dominated and tensile stresses when expansion dominated in the 0° plies. The finding points out that 10% reduction in warpage and 33% reduction in process time can be obtained by selecting cure cycle parameters that allow tensile stresses development during the cure process in the 0° plies.Aerospace Manufacturing Technologie
Identifiability of cure models
No full textCure models can be used for censored survival data in which a fraction of the observations do not exhibit the event of interest despite long-term follow-up. In this paper we investigate the identifiability of two forms of the cure model, a standard cure model based on a mixture distribution and a non-mixture proportional hazards (PH) model with long-term survivors. In the standard cure model, except for the case where the conditional survival function is independent of covariates and the mixture probability is an arbitrary function of a covariate we show that the parameters of the standard cure model are identified. In the non-mixture PH model, we show the model is identifiable if the distribution function is specified.Cure model Latency Long-term incidence Logistic-Kaplan-Meier model Logistic-proportional hazards model
Interaction of Acid Gases SO<sub>2</sub> and NO<sub>2</sub> with Coordinatively Unsaturated Metal Organic Frameworks: M-MOF-74 (M = Zn, Mg, Ni, Co)
No full textFull text access from Treasures at UT Dallas is available only to current UTD affiliates.In situ infrared spectroscopy and ab initio density functional theory (DFT) calculations are combined to study the interaction of the corrosive gases SO₂ and NO₂ with metal organic frameworks M-MOF-74 (M = Zn, Mg, Ni, Co). We find that NO₂ dissociatively adsorbs into MOF-74 compounds, forming NO and NO₃̅. The mechanism is unraveled by considering the Zn-MOF-74 system, for which DFT calculations show that a strong NO₂-Zn bonding interaction induces a significant weakening of the N-O bond, facilitating the decomposition of the NO₂ molecules. In contrast, SO₂ is only molecularly adsorbed into MOF-74 with high binding energy (>90 kJ/mol for Mg-MOF-74 and >70 for Zn-MOF-74). This work gives insight into poisoning issues by minor components of flue gases in metal organic frameworks materials.Department of Energy Grant No. DE-FG02-08ER46491; Simons Foundation Grant No. 391888.Erik Jonsson School of Engineering and Computer Scienc
Factors associated with cure after therapy of clinical mastitis caused by Staphylococcus aureus
No full textOne hundred and fifty-nine cases of clinical Staphylococcus aureus mastitis were analyzed to detect factors associated with bacteriological cure after therapy. On 100 Dutch dairy farms, data were collected from four clinical trials with five intramammary treatment regimes designed to treat beta-lactamase-positive pathogens. Infected quarters were treated three times, with a 12-h interval between treatments. Treatment was extended for 2 d if results of the trial treatment were, according to the owner, not satisfactory. The overall bacteriological cure rate was 52%. The bacteriological cure rate of clinical beta-lactamase-negative S. aureus mastitis was significantly higher than that of clinical beta-lactamase-positive S. aureus mastitis. Bacteriological cure was also significantly higher if somatic cell count of the cow was low at the milk recording prior to the onset of the clinical mastitis. The bacteriological cure rate of clinical beta-lactamase-negative S. aureus mastitis was also significantly higher after an extended treatment compared with no extended treatment. The seriousness of the various clinical symptoms and the bacteriological cure rate of clinical S. aureus mastitis were not associated.LR: 20031114; PUBM: Print; JID: 2985126R; 0 (Antibiotics, Antitubercular); 0 (Cephalosporins); 0 (Penicillins); 1066-17-7 (Colistin); 13292-46-1 (Rifampin); 25953-19-9 (Cefazolin); 61-72-3 (Cloxacillin); 69-53-4 (Ampicillin); 738-70-5 (Trimethoprim); ppublishSource type: Electronic(1
Optimal cure cycles for manufacturing of thick composite parts using multi-objective genetic algorithms
No full textThe paper addresses the multi-objective optimization of the cure process of a Vacuum Assisted Resin Transfer Molding for components ranging from 40 to 100 mm thickness and aims to investigate the effect of thickness on the identification and quantification of a set of optimal cure profiles that minimize temperature overshoot and process time. Optimal cure solutions are sought among three dwells temperature profiles and are compared to the manufacturer’s recommended cure cycle (MRCC). The methodology successfully approximates the efficient fronts for the three different cases under study (40, 70 and 100mm) and points out the efficiency opportunity available compared to MRCC. In the case of 70 and 100 mm thick component temperature overshoot reductions of about 75% are achievable and 67% reduction in process time. The results also suggest a change in the objectives’ landscape for the higher thicknesses in the vertical region of the Pareto.Aerospace Manufacturing TechnologiesStructural Integrity & Composite
Efficacy of intramammary tilmicosin and risk factors for cure of Staphylococcus aureus infection in the dry period
No full textThe objective ofthis study was to evaluate the efficacy of intramammary tilmicosin, administered at drying-off, for eliminating Staphylococcus aureus infection, and to identify risk factors for S. aureus cure during the dry period. A total of 219 naturally infected cows, representing 308 quarters, were randomized to receive either one of two treatments at drying-off. Cows received either an intramammary infusion of 500 mg of benzathine cloxacillin, or a sterile solution containing 1,500 mg of tilmicosin. All cows had quarter milk samples taken aseptically three times before dry-off, and at wk 1, 2, and 4 of the subsequent lactation. Overall, 62% of cows and 67.5% of quarters infected with S. aureus cured during the dry period. The cure following administraton of tilmicosin was 67.3 and 72.5% for cows and quarters, respectively. By comparison, the cure achieved with cloxacillin was 56.9 and 62.9% of cows and quarters. Cows receiving tilmicosin were 2.1 times more likely to cure. The cure rate for cows decreased as the linear score on the last DHI test increased, and as the amount of S. aureus being shed increased. Quarters that cultured positive multiple times before drying-off were less likely to cure. Staphylococcus aureus infections located in front quarters of the udder were 2 times more likely to cure than those in hind quarters. Results of this study demonstrate that intramammary tilmicosin at drying-off is efficacious in curing existing S. aureus during the dry period. Risk factors associated with the cure of S. aureus were identified.LR: 20061115; PUBM: Print; JID: 2985126R; 0 (Anti-Bacterial Agents); 0 (Macrolides); 108050-54-0 (tilmicosin); 1401-69-0 (Tylosin); 23736-58-5 (benzathine cloxacillin); 61-72-3 (Cloxacillin); ppublishSource type: Electronic(1
Joint longitudinal-survival-cure model with application in prostate cancer studies.
No full textMany medical investigations generate both longitudinal and survival data. Methods for the combined analysis of both kinds of data have been developed in recent years. In prostate cancer studies, patients are usually monitored and PSA are measured periodically after they received treatment. It is also common for there to be long term survivors or cured patients. This dissertation extends the joint modeling method to analyze data from prostate cancer studies, by adding a mixture structure to the survival model component of the joint model. There are 3 components in our model: an incidence model for cure status of a patient, a longitudinal model for a biomarker, and a survival model for susceptibles or not cured patients. A Markov chain Monte Carlo estimation method is developed. Two different versions of the same data are analyzed in this dissertation. The version with shorter followup (till March 1995) is analyzed with results compared to those obtained from a Monte Carlo EM algorithm. The version with longer followup (till February 2001) is analyzed using a more flexible model. In this version, we utilize the actual survival information for patients who received hormonal therapy (HT) as a salvage therapy and treat HT as a time-dependent covariate. We include the slope of the longitudinal profile as a time-dependent covariate. We also consider additional baseline covariates in the joint model. To accommodate the heavier tail manifested by the data, we use a t distribution for the measurement error term in the longitudinal model. We use our model to predict cancer recurrence for censored (alive) patients under the assumptions that they either do or do not receive HT right after the censoring time. The reconstruction of marginal survival distributions is carried out using multiple imputations. We assess the fit of the model using a validation data set. We investigate whether incorporating a cure component in the survival model provides a better fit to the data, by using Bayesian approaches for model selection. Our simulation study found that the CPO statistic performs better than BIC and Bayes factors. We apply CPO to a model selection problem for the prostate cancer data set. We find that joint modeling with a cure model component provides a better fit than without the cure model component.PhDBiological SciencesBiostatisticsHealth and Environmental SciencesPublic healthPure SciencesStatisticsUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/124225/2/3122082.pd
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