117 research outputs found
Gender specific regulation of hepatic aquaporin-9 and glycerol kinase expression in starved rats
No full textSFEM for velocity-pressure and stream function formulations of surface Stokes equations
No full textCode to produce the SFEM results in the paper "Finite element discretization methods for velocity-pressure and stream function formulations of surface Stokes equations" by Philip Brandner, Thomas Jankuhn, Simon Praetorius, Arnold Reusken, and Axel VoigtThe author wishes to thank the German Research Foundation (DFG) for financial support within the Research Unit "Vector- and Tensor-Valued Surface PDEs'" (FOR 3013) with project no. VO 899/22-1. We further acknowledge computing resources provided by ZIH at TU Dresden and within project PFAMDIS at FZ Jülich
The Significance of the Choroid Plexus for Cerebral Iron Homeostasis
No full textThe homeostasis of the brain interstitial fluid is sustained by two brain barriers, i.e. the blood-brain barrier (BBB) formed by brain capillary endothelial cells and the blood-cerebrospinal fluid (CSF) barrier, which both selectively allow transport of nutrients and metals into the brain. Iron is essential for normal brain function but detrimental in excess, hence justifying a tightly regulated cerebral iron homeostasis based on the transport of iron from the periphery across the brain barriers. Regulation of iron uptake involves proteins like transferrin receptor, divalent metal transporter 1 (DMT1), ferritin and ferroportin. It is commonly accepted that iron uptake and transport across the blood-CSF barrier are mediated by the transferrin receptor although by two principally different mechanisms. Transferrin complexed with iron can engage with the transferrin receptor and traverse the choroid plexus epithelial cells by receptor-mediated transcytosis. Moreover, Fe3+ can detach from transferrin within slightly acidic endosomes, escape into the cytosol by DMT1-mediated pumping after Fe3+ has been reduced to Fe2+. In the cytosol, iron is either stored in ferritin or exported into the CSF mediated by ferroportin. Within the CSF, iron binds to transferrin primarily synthesized or secreted by the choroid plexus. Non-transferrin-bound iron (NTBI) is present in the CSF, favoring the argument that the iron-binding capacity of transferrin is exceeded in CSF. We hypothesize that transferrin derived from the CSF play a crucial role for binding of iron transported through the BBB, and for further transport of iron within the brain interstitium and subsequent delivery to transferrin receptor-expressing neurons
Praetorius, N. (2001a) Précis for multiple review of "Principles of Cognition, Language and Action", Psycoloquy, 12(027).
No full textThe book exposes serious flaws in the reductionist assumptions of Mind and Matter of Naturalism and Constructivism, which underlie research and theorizing on cognition, language and action within current academic psychology. The author argued for alternative tenable assumptions about the relation between mental and material reality which, as a matter of principle, must be taken for granted, and be the point of departure for all further investigations into both reality and our descriptions of it. It is the intention to show that the assumptions and principles derived from the arguments in the book offer a consistent foundation for a science of psychology. Furthermore, it seems that they open up new and straightforward ways of dealing with key-issues of truth and intentionality, subjectivity and objectivity, of relevance to psychology, philosophy and the humanities
Syntagma Musicum II: De Organographia, Parts III – V with Index
No full textMichael Praetorius (1571–1621) achieved distinction as a practicing musician: as organist and Kapellmeister at Wolfenbüttel, Dresden and Magdeburg, and (in his later years) by incessant travel to fulfill commissions at various central German courts. Amid his travels Praetorius found time to publish an impressive series of collections of musical compositions, in all more than a thousand works. Praetorius’s three-volume Syntagma musicum (Musical Encyclopedia) belongs to the last years of his life. Volume I, Musicae artis analecta (1614/15, in Latin), treats principles and practices of religious music, from a decidedly Lutheran perspective. Volume II, De organographia (1619, in German) deals with musical instruments, in particular with the organ. Volume III, Termini musici (1619, in German) explores the practice of music, both improvisation and composition. The Syntagma musicum is the first comprehensive treatment of music in the German language.
The publication before you is the first English translation of Volume II, Parts III–V, specifically on the organ. Its belated appearance would have puzzled Praetorius, who declares the organ to be “a perfect (indeed one might also say ‘most perfect’) musical instrument … which … takes pride of place above all other musical instruments, most of which can be incorporated into this single instrument.” This work includes: A precise description of ancient and modern organs, their manual and pedal keyboards, bellows, stoplists, and various kinds of stops, as well as how to tune regals and harpsichords easily and precisely; and what to consider when accepting a [newly‑built] organ, together with an appended detailed table …
This edition shows the German original on the left and the English translation on the facing right-hand pages. Translator Dr. Quentin Faulkner is Larson Professor of Organ and Music Theory/History (emeritus) at the University of Nebraska-Lincoln. Dr Faulkner holds the degrees B.Mus. cum laude from Westminster Choir College, M.S.M. and M.Th. from Southern Methodist University, and S.M.D. from Union Theological Seminary. He is the author of J. S. Bach’s Keyboard Technique: A Historical Introduction (1984) and Wiser Than Despair: The Evolution of Ideas in the Relationship of Music and the Christian Church (1996), and the translator of Jacob Adlung’s Musica mechanica organoedi • Musical mechanics for the organist (2011). He was formerly an organist at the Cathedral Church of St. John the Divine in New York City.https://digitalcommons.unl.edu/zeabook/1023/thumbnail.jp
Transport across the choroid plexus epithelium
No full textThe choroid plexus epithelium is a secretory epithelium par excellence. However, this is perhaps not the most prominent reason for the massive interest in this modest-sized tissue residing inside the brain ventricles. Most likely, the dominant reason for extensive studies of the choroid plexus is the identification of this epithelium as the source of the majority of intraventricular cerebrospinal fluid. This finding has direct relevance for studies of diseases and conditions with deranged central fluid volume or ionic balance. While the concept is supported by the vast majority of the literature, the implication of the choroid plexus in secretion of the cerebrospinal fluid was recently challenged once again. Three newer and promising areas of current choroid plexus-related investigations are as follows: 1) the choroid plexus epithelium as the source of mediators necessary for central nervous system development, 2) the choroid plexus as a route for microorganisms and immune cells into the central nervous system, and 3) the choroid plexus as a potential route for drug delivery into the central nervous system, bypassing the blood-brain barrier. Thus, the purpose of this review is to highlight current active areas of research in the choroid plexus physiology and a few matters of continuous controversy.</p
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