2,603 research outputs found
DNA repair: PARP – another guardian angel?
No full textAbstractCell lines and mice defective in poly(ADP-ribose) polymerase (PARP) have elevated spontaneous genetic rearrangements and abnormal responses to stresses. These results may be explained by an altered response to damage induced by free radicals, and suggest that PARP limits genomic instability from such damage
Simple drag prediction strategies for an Autonomous Underwater Vehicle’s hull shape
No full textThe range of an AUV is dictated by its finite energy source and minimising the energy consumption is required to maximise its endurance. One option to extend the endurance is by obtaining the optimum hydrodynamic hull shape with balancing the trade-off between computational cost and fluid dynamic fidelity. An AUV hull form has been optimised to obtain low resistance hull. Hydrodynamic optimisation of hull form has been carried out by employing five parametric geometry models with a streamlined constraint. Three Genetic Algorithm optimisation procedures are applied by three simple drag predictions which are based on the potential flow method. The results highlight the effectiveness of considering the proposed hull shape optimisation procedure for the early stage of AUV hull desig
THE CORRELATION OF THE MEDIEVAL EUROPEAN STATE AND LAW IN THE DOCTRINE OF P.A. KROPOTKIN
No full textThe actual task of Russian state studies and jurisprudence remains the opposition to the ideological and theoretical constructions of Russian classical anarchism. Purpose: to establish the most significant features and disadvantages of P.A. Kropotkin’s interpretation of the correlation of state and law on the example of Medieval Europe. When writing the article, the author applies interdisciplinary and class approaches. General scientific and specific scientific methods are used: historical, problem-theoretical, formal-logical, textual. Materials: monuments of law, other historical sources, foreign and national historiography. The analysis shows that P.A. Kropotkin’s works are characterised not only by a pronounced anti-exploitation pathos, but also by an equally pronounced tendentiousness. Results: aprioriism, anti-statism and antilegism, radical localism, Eurocentrism, diffusionism, cyclism and catastrophism, clothed in the form of postulates, predetermined P.A. Kropotkin’s one-sided interpretations of the interaction of the medieval European state with positive and customary law. In the first case, it took a purely causative form, and in the second, it was predominantly conflictual. These are the key flaws of P.A. Kropotkin’s correlation concept
Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome
No full textHypomorphic mutations in DNA ligase IV (LIG4) cause a human syndrome of immunodeficiency, radiosensitivity, and growth retardation due to defective DNA repair by the nonhomologous end-joining (NHEJ) pathway. Lig4-null mice are embryonic lethal, and better mouse models are needed to study human LigIV syndrome. We recently identified a viable mouse strain with a Y288C hypomorphic mutation in the Lig4 gene. Lig4Y288C mice exhibit a greater than 10-fold reduction of LigIV activity in vivo and recapitulate the immunodeficiency and growth retardation seen in human patients. Here, we have demonstrated that the Lig4Y288C mutation leads to multiple defects in lymphocyte development and function, including impaired V(D)J recombination, peripheral lymphocyte survival and proliferation, and B cell class switch recombination. We also highlight a high incidence of thymic tumors in the Lig4Y288C mice, suggesting that wild-type LigIV protects against malignant transformation. These findings provide explanations for the complex lymphoid phenotype of human LigIV syndrome.This work was funded by the Wellcome Trust and the NIHR Biomedical Research Centre Programme. A. Nijnik was supported by a Wellcome Trust Prize Studentship. P.A. Jeggo is supported by the Medical Research Council, the Association for International Cancer Research, an Integrated Project EU grant, DNA Repair (LSHG-CT-2005-512113), and the United Kingdom Department of Health
Flow-induced gate vibrations: Prevention of sef-excitation computation of dynamic gate behaviour and the use of models
No full textThe objective of this study is to develop design criteria for the dynamic behaviour of gates and valves. To this end, a resume of existing theories is given as well as an extended analysis of the added water mass, hydrodynamic rigidity and damping (also negative damping or self-excitation) and excitation by turbulent flow. New computation methods are presented for self-exciting vibrations: The ensuing introduction of an instability indicator permits the prediction of such vibrations in the design phase. Methods are described to calculate the added water mass and water damping in flowing water. Also treated are the instability of overflowing and falling water nappes, the response of a mass-spring system to noise excitation by turbulence, and the technique of hydroelastic models. Prior publications by the author on these subjects are to be found in the Appendices.Hydraulic EngineeringCivil Engineering and Geoscience
Quality and qualities of design studies, design research and design
No full textGreen Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Methodologie en Organisatie van Desig
Views of P.A. Krushevan on the National Problem in Russia: Moldavian or Russian Nationalist
No full textThe article deals with the national identity of P.A. Krushevan. Being of Moldavian nationality, he was a Russian conservative writer and journalist. At the beginning of the 19th century he served as a Russian nationalist in the political arena. The author shows that he was a supporter of Moldavian national traditions and a personality of the Moldavian national movement. At the same time Krushevan was an «imperial nationalist» and a Russian statesman. In behalf of Bessarabia peasants, he exposed the economic activity of «plutocracy», but he was a stranger to domestic anti-Semitism
The Nigerian Co-operative Law: Taking the Baton from P.A. Oluyede
No full textSome of the challenges hindering the development of co-operatives and their governing laws in Nigeria are the inadequacy of literature, and the lack of standardized classification on the subject of co-operative law. With the aim to identify and espouse relevant literature on the subject matter, this paper seeks to collect, collate and review the relevant literature. A classic was identified in the work of P.A. Oluyede (1988) Nigeria Administrative Law, in chapter four, entitled “Public Corporations, and Public Enterprises.” Among other findings, the learned author dedicated the chapter to the historical development of Nigerian co-operative societies and their governing laws, situated cooperatives as public enterprises, and made recommendations. Furthermore, it was observed that there have been few contributions within the annals of the Nigerian academic and research community on co-operative law. Thus, Oluyede’s classics retains its position as a primary reference material for the modernization of the Nigerian cooperative law and sets the path for its standardization. However, supposedly consequential development has remained elusive, hence the imperatives to build on some of the positions espoused in Oluyede’s chapter in view of current realities. Although P.A Oluyede’s contribution retains its position as a top-notch reference material, some of the positions canvassed are no longer applicable to Nigerian co-operatives, hence the need to review Nigerian cooperative law as recommended. 
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