561 research outputs found
The Wigan Murder: Examination and Confession of John Healey
No full textJohn Healey awaits trial for a murder that he doesn\u27t remember.https://egrove.olemiss.edu/kgbsides_uk/2159/thumbnail.jp
Negative frequency‐dependent interactions can underlie phenotypic heterogeneity in a clonal microbial population
No full textGenetically identical cells in microbial populations often exhibit a remarkable degree of phenotypic heterogeneity even in homogenous environments. Such heterogeneity is commonly thought to represent a bet‐hedging strategy against environmental uncertainty. However, evolutionary game theory predicts that phenotypic heterogeneity may also be a response to negative frequency‐dependent interactions that favor rare phenotypes over common ones. Here we provide experimental evidence for this alternative explanation in the context of the well‐studied yeast GAL network. In an environment containing the two sugars glucose and galactose, the yeast GAL network displays stochastic bimodal activation. We show that in this mixed sugar environment, GAL‐ON and GAL‐OFF phenotypes can each invade the opposite phenotype when rare and that there exists a resulting stable mix of phenotypes. Consistent with theoretical predictions, the resulting stable mix of phenotypes is not necessarily optimal for population growth. We find that the wild‐type mixed strategist GAL network can invade populations of both pure strategists while remaining uninvasible by either. Lastly, using laboratory evolution we show that this mixed resource environment can directly drive the de novo evolution of clonal phenotypic heterogeneity from a pure strategist population. Taken together, our results provide experimental evidence that negative frequency‐dependent interactions can underlie the phenotypic heterogeneity found in clonal microbial populations.National Institutes of Health (U.S.) (New Innovator Award)Paul G. Allen Family Foundation. Allen Distinguished Investigator ProgramPew Charitable Trusts (Pew Scholar in the Biomedical Sciences)Alfred P. Sloan Foundation. Fellowshi
Supplemental Material - Cervical Spine Motion Requirements From Night Vision Goggles May Play a Greater Role in Chronic Neck Pain than Helmet Mass Properties
No full textSupplemental Material for Cervical Spine Motion Requirements From Night Vision Goggles May Play a Greater Role in Chronic Neck Pain than Helmet Mass Properties by Jeff M. Barrett, Laura A. Healey, Steven L. Fischer and Jack P. Callaghan in Human Factors</p
Atrial fibrillation is associated with increased mortality: Causation or association?
No full textThis editorial refers to ‘All-cause mortality in 272 186 patients hospitalized with incident atrial fibrillation 1995–2008: a Swedish nationwide long-term case–control study’, by T. Andersson et al., on page 1061Darryl P. Leong, John W. Eikelboom, Jeff S. Healey, and Stuart J. Connoll
Stasis in music and the formation of musical states and A portrait of an infant (on coming into being)
No full textThe perception of structure in music is frequently based upon a theoretical understanding of the musical elements. This basis tends toward stylized analysis of a specific element of the music, for instance, pitch, form, rhythm, et cetera, with the goal of revealing the tendencies or development of this element throughout the piece. Not frequently discussed is the function and significance of stasis in perceiving the structure of music. A “moment” of stasis, as Stockhausen called it, can alternatively be understood as a “state of existence.” A static section of music can give a sensation of inactivity often comprehended as a slowing of the music!s forward momentum, or temporality, as contrasted with more dynamic states. A musical state is reliant upon a particular treatment of its internal elements, incorporating varying degrees of limitation and change. Analysis of both dynamic and static states is considered in an endeavor to further understand the function of musical stasis in the structure of a composition.Ph. D.Includes bibliographical referencesby Craig Healey Woodwar
CJK_Supplemental_Material – Supplemental material for Canadian Nephrologist Views Regarding Stroke and Systemic Embolism Prevention in Dialysis Patients With Nonvalvular Atrial Fibrillation: A Survey
No full textSupplemental material, CJK_Supplemental_Material for Canadian Nephrologist Views Regarding Stroke and Systemic Embolism Prevention in Dialysis Patients With Nonvalvular Atrial Fibrillation: A Survey by David Collister, Jeff S. Healey, David Conen, K. Scott Brimble, Claudio Rigatto, Ziv Harel, Manish M. Sood and Michael Walsh in Canadian Journal of Kidney Health and Disease</p
Divergence in Dialogue
No full textCopyright: 2014 Healey et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.This work was supported by the Economic and Social Research Council (ESRC; http://www.esrc.ac.uk/) through the DynDial project (Dynamics of Conversational Dialogue, RES-062-23-0962) and the Engineering and Physical Sciences Research Council (EPSRC; http://www.epsrc.ac.uk/) through the RISER
project (Robust Incremental Semantic Resources for Dialogue, EP/J010383/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
Perioperative atrial fibrillation and the long-term risk of ischemic stroke
No full textIMPORTANCE: Clinically apparent atrial fibrillation increases the risk of ischemic stroke. In contrast, perioperative atrial fibrillation may be viewed as a transient response to physiological stress, and the long-term risk of stroke after perioperative atrial fibrillation is unclear. OBJECTIVE: To examine the association between perioperative atrial fibrillation and the long-term risk of stroke. DESIGN, SETTING, AND PARTICIPANTS: Retrospective cohort study using administrative claims data on patients hospitalized for surgery (as defined by surgical diagnosis related group codes), and discharged alive and free of documented cerebrovascular disease or preexisting atrial fibrillation from nonfederal California acute care hospitals between 2007 and 2011. Patients undergoing cardiac vs other types of surgery were analyzed separately. MAIN OUTCOMES AND MEASURES: Previously validated diagnosis codeswere used to identify ischemic strokes after discharge from the index hospitalization for surgery. The primary predictor variable was atrial fibrillation newly diagnosed during the index hospitalization, as defined by previously validated present-on-admission codes. Patients were censored at postdischarge emergency department encounters or hospitalizations with a recorded diagnosis of atrial fibrillation. RESULTS: Of 1 729 360 eligible patients, 24 711 (1.43%; 95%CI, 1.41%-1.45%) had new-onset perioperative atrial fibrillation during the index hospitalization and 13 952 (0.81%; 95%CI, 0.79%-0.82%) experienced a stroke after discharge. In a Cox proportional hazards analysis accounting for potential confounders, perioperative atrial fibrillation was associated with subsequent stroke both after noncardiac and cardiac surgery. (Table Presented) The association with stroke was significantly stronger for perioperative atrial fibrillation after noncardiac vs cardiac surgery (P < .001 for interaction). CONCLUSIONS AND RELEVANCE: Among patients hospitalized for surgery, perioperative atrial fibrillation was associated with an increased long-term risk of ischemic stroke, especially following noncardiac surgery. Copyright 2014 American Medical Association. All rights reserved
Writing Partnerships in Higher Education: A Guide for Academics and HE Professionals
No full textThis is an Accepted Manuscript of a book chapter published by Routledge in [Writing partnerships in higher education: A guide for academics and HE professionals] on [date of publication], available online: http://www.routledge.com/[BOOK ISBN URL]International collaborative writing groups (ICWGs), working with a sponsoring organization, have had a major impact on capacity building and developing learning communities, as well as producing quality outputs (Healey, 2017; ISSOTL, nd). They are about “working creatively, critically and collaboratively to address a scholarship of teaching and learning (SoTL) challenge from a multi-perspective lens” (Abrahamson, 2023). ICWGs usually involve groups of staff and students from different countries working together with a leader in small teams to write articles about pre-selected topics for submission to an international peer-reviewed journal. The process normally lasts around 18 months from announcement to submission, with participants working mostly online. The highlight is when all the teams come together for between 2 and 3 days, before or after an international conference, to work intensively on their articles. Whilst this model has predominantly been used within the context of SoTL, it is easily transferable to other topics and disciplines.
We ran the first full ICWG in SoTL from 2004-06 for geographers, drawing on the experience of running an international seminar in 1999 that piloted many of the features that subsequently came to characterise ICWGs (Healey, 2006; Healey et al., 2000)). Subsequently in 2012 we introduced ICWGs to ISSOTL (Healey et al., 2013). We have experienced each of the three ICWG roles – event facilitator, group leader, and co-author – several times in the last 25 years (Table 1). In this chapter we offer advice based on our reflections on these experiences, and the research evidence on the opportunities and challenges ICWGs have provided for participants. We outline some suggestions for how participants playing the different ICWG roles may make the most of their experiences, and how the model might be used by the wider SoTL community and other academic communities to support local, national, and institutional collaborative writing groups. We begin by exploring the nature and purposes of ICWGs in SoTL
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